In vivo mouse brain tomography by fast dual-scanning photoacoustic imaging system based on array transducer

2008 ◽  
Author(s):  
Sihua Yang ◽  
Da Xing
Keyword(s):  
Mouse Brain ◽  
Imaging System ◽  
Photoacoustic Imaging ◽  
Array Transducer ◽  
Brain Tomography

Monitoring of Blood Flow by Drug Stimulation on Mouse Brain Using Non-Invasive Photoacoustic Imaging Technology

2007 ◽  
Vol 364-366 ◽  
pp. 1123-1127
Author(s):  
Shi Hua Yang ◽  
Ye Qi Lao
Keyword(s):  
Blood Flow ◽  
Mouse Brain ◽  
Light Absorption ◽  
Brain Function ◽  
Photoacoustic Imaging ◽  
Non Invasive ◽  
Mouse Cerebral Cortex ◽  
Flow Changes ◽  
The Brain

The highlight of photoacosutic imaging (PAI) is a method that combines ultrasonic resolution with high contrast due to light absorption. Photoacoustic signals carry the information of the light absorption distribution of biological tissue, which is often related to its character of structure, physiological and pathological changes because of different physiology conditions in response to different light absorption coefficients. A non-invasive PAI system was developed and successfully acquired in vivo images of mouse brain. Based on the intrinsic PA signals from the brain, the vascular network and the detailed structures of the mouse cerebral cortex were clearly visualized. The ability of PAI monitoring of cerebral hemodynamics was also demonstrated by mapping of the mouse superficial cortex with and without drug stimulation. The extracted PA signals intensity profiles obviously testified that the cerebral blood flow (CBF) in the mouse brain was changed under the stimulation of acetazolamide (ACZ). The experimental results suggest that PAI can provide non-invasive images of blood flow changes, and has the potential for brain function detection.

In vivo photoacoustic imaging of nude mice vasculature using a photoacoustic imaging system based on a commercial ultrasound scanner

2008 ◽  
Author(s):  
Ladislav Jankovic ◽  
Khalid Shahzad ◽  
Yao Wang ◽  
Michael Burcher ◽  
Frank-Detlef Scholle ◽  
...  
Keyword(s):  
Nude Mice ◽  
Imaging System ◽  
Photoacoustic Imaging ◽  
Ultrasound Scanner

scholarly journals In vivo imaging of swimming micromotors using hybrid high-frequency ultrasound and photoacoustic imaging

2020 ◽  
Author(s):  
Azaam Aziz ◽  
Joost Holthof ◽  
Sandra Meyer ◽  
Oliver G. Schmidt ◽  
Mariana Medina-Sánchez
Keyword(s):  
High Frequency ◽  
Imaging System ◽  
Ex Vivo ◽  
Photoacoustic Imaging ◽  
Imaging Techniques ◽  
High Frequency Ultrasound ◽  
Living Organisms ◽  
And Function ◽  
Frequency Ultrasound

AbstractThe fast evolution of medical micro- and nanorobots in the endeavor to perform non-invasive medical operations in living organisms boosted the use of diverse medical imaging techniques in the last years. Among those techniques, photoacoustic (PA) tomography has shown to be promising for the imaging of microrobots in deep-tissue (ex vivo and in vivo), as it possesses the molecular specificity of optical techniques and the penetration depth of ultrasound imaging. However, the precise maneuvering and function control of microrobots, in particular in living organisms, demand the combination of both anatomical and functional imaging methods. Therefore, herein, we report the use of a hybrid High-Frequency Ultrasound (HFUS) and PA imaging system for the real-time tracking of magnetically driven micromotors (single and swarms) in phantoms, ex vivo, and in vivo (in mice bladder and uterus), envisioning their application for targeted drug-delivery.

scholarly journals Photoacoustic molecular imaging using combined acupuncture and gold nanorods as a composite contrast agent

2019 ◽  
Vol 12 (03) ◽  
pp. 1941004
Author(s):  
Dan Wu ◽  
Xinxin Zhang ◽  
Jian Rong ◽  
Huabei Jiang
Keyword(s):  
Contrast Agent ◽  
Contrast Enhancement ◽  
Mouse Brain ◽  
Gold Nanorods ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Local Concentration ◽  
Quantitative Results ◽  
Zusanli Acupoint

In this study, we developed a novel photoacoustic imaging technique based on poly (ethyleneglycol)-coated (PEGylated) gold nanorods (PEG-GNRs) (as the contrast agent) combined with traditional Chinese medicine (TCM) acupuncture (as the auxiliary method) for quantitatively monitoring contrast enhancement in the vasculature of a mouse brain in vivo. This study takes advantage of the strong near-infrared absorption (peak at [Formula: see text][Formula: see text]nm) of GNRs and the ability to adjust the hemodynamics of acupuncture. Experimental results show that photoacoustic tomography (PAT) successfully reveals the optical absorption variation of the vasculature of the mouse brain in response to intravenous administration of GNRs and acupuncture at the Zusanli acupoint (ST36) both individually and combined. The quantitative measurement of contrast enhancement indicates that the composite contrast agents (integration of acupuncture and GNRs) would greatly enhance the photoacoustic imaging contrast. The quantitative results also have the potential to estimate the local concentration of GNRs and even the real-time effects of acupuncture.

Development of Real-Time 3-D Photoacoustic Imaging System Employing Spherically Curved Array Transducer

2017 ◽  
Vol 64 (8) ◽  
pp. 1223-1233 ◽  
Author(s):  
Ryo Nagaoka ◽  
Takuya Tabata ◽  
Ryo Takagi ◽  
Shin Yoshizawa ◽  
Shin-Ichiro Umemura ◽  
...  
Keyword(s):  
Real Time ◽  
Imaging System ◽  
Photoacoustic Imaging ◽  
Array Transducer ◽  
Curved Array Transducer

scholarly journals Targeted Imaging of Orthotopic Prostate Cancer by Using Clinical Transformable Photoacoustic Molecular Probe

2020 ◽  
Author(s):  
Chen Qiu ◽  
Yuanyuan Bai ◽  
Tinghui Yin ◽  
Xiaoyan Miao ◽  
Rongkang Gao ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Imaging System ◽  
Photoacoustic Imaging ◽  
Current Trend ◽  
Molecular Probe ◽  
High Yield ◽  
Control Group ◽  
Targeted Imaging ◽  
Normal Prostate

Abstract Background: To obtain high-yield histological samples by targeted prostate cancer (PCa) biopsy is the current trend compared with transrectal ultrasound (TRUS)-guided systematic histological biopsy, which is regarded as the gold standard for prostate cancer (PCa) diagnosis. In this paper, we present a targeted PCa imaging strategy using a real-time molecular photoacoustic imaging system integrated with a handheld US probe (PAI/US) and synthesized an integrin α v β 3 targeted probe based on ICG (cRGD–ICG). Results: A small molecular PAI probe was synthesized and exhibited excellent targeted imaging ability in vitro . In vivo photoacoustic imaging was carried out after intravenous injection of cRGD-ICG in orthotopic PCa-bearing rats under the facilitation of the PAI/US system. Maximum molecular photoacoustic signals were observed in the tumor area in vivo after the probe injection, which showed 3.8-fold higher signal enhancement than that in the control group ( P < 0.05). Significantly higher cRGD-ICG accumulation was observed under confocal microscopy in the tumor region than in normal prostate tissue. Conclusions: All our results showed that the comprehensive strategy provided a high-yield and reliable method for PCa diagnosis and targeted prostate biopsy, with great clinical translation potential.

Fabrication, Packaging, and Catheter Assembly of 2D CMUT Arrays for Endoscopic Ultrasound and Cardiac Imaging

2015 ◽  
Author(s):  
Azadeh Moini ◽  
Amin Nikoozadeh ◽  
Jung Woo Choe ◽  
Butrus T. Khuri-Yakub ◽  
Chienliu Chang ◽  
...  
Keyword(s):  
Medical Imaging ◽  
Optical Fibers ◽  
Flip Chip ◽  
Focused Ultrasound ◽  
Imaging System ◽  
Photoacoustic Imaging ◽  
Flexible Substrate ◽  
3D Ultrasound ◽  
High Intensity Focused Ultrasound

Ultrasound is increasingly in demand as a medical imaging tool and can be particularly beneficial in the field of intracardiac echocardiography (ICE). However, many challenges remain in the development of a 3D ultrasound imaging system. We have designed and fabricated a quad-ring capacitive micromachined ultrasound transducer (CMUT) for real-time, volumetric medical imaging. Each CMUT array is composed of four concentric, independent ring arrays, each operating at a different frequency, with 128 elements per ring. In this project, one ring will be used for imaging. A large (5mm diameter) lumen is available for delivering other devices, including high intensity focused ultrasound transducers for therapeutic applications or optical fibers for photoacoustic imaging. We address several challenges in developing a 3D imaging system. Through wafer vias are incorporated in the fabrication process for producing 2D CMUT arrays. Device integration with electronics is achieved through solder bumping the arrays, designing a flexible PCB, and flip chip bonding CMUT and ASICs to the flexible substrate. Finally, we describe a method for integrating the flex assembly into a catheter shaft. The package, once assembled, will be used for in-vivo open chest experiments.

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