Fabrication, Packaging, and Catheter Assembly of 2D CMUT Arrays for Endoscopic Ultrasound and Cardiac Imaging

Author(s):  
Azadeh Moini ◽  
Amin Nikoozadeh ◽  
Jung Woo Choe ◽  
Butrus T. Khuri-Yakub ◽  
Chienliu Chang ◽  
...  

Ultrasound is increasingly in demand as a medical imaging tool and can be particularly beneficial in the field of intracardiac echocardiography (ICE). However, many challenges remain in the development of a 3D ultrasound imaging system. We have designed and fabricated a quad-ring capacitive micromachined ultrasound transducer (CMUT) for real-time, volumetric medical imaging. Each CMUT array is composed of four concentric, independent ring arrays, each operating at a different frequency, with 128 elements per ring. In this project, one ring will be used for imaging. A large (5mm diameter) lumen is available for delivering other devices, including high intensity focused ultrasound transducers for therapeutic applications or optical fibers for photoacoustic imaging. We address several challenges in developing a 3D imaging system. Through wafer vias are incorporated in the fabrication process for producing 2D CMUT arrays. Device integration with electronics is achieved through solder bumping the arrays, designing a flexible PCB, and flip chip bonding CMUT and ASICs to the flexible substrate. Finally, we describe a method for integrating the flex assembly into a catheter shaft. The package, once assembled, will be used for in-vivo open chest experiments.

2014 ◽  
Vol 2014 ◽  
pp. 1-16 ◽  
Author(s):  
Victoria Sherwood ◽  
John Civale ◽  
Ian Rivens ◽  
David J. Collins ◽  
Martin O. Leach ◽  
...  

A system which allows magnetic resonance (MR) and ultrasound (US) image data to be acquired simultaneously has been developed. B-mode and Doppler US were performed inside the bore of a clinical 1.5 T MRI scanner using a clinical 1–4 MHz US transducer with an 8-metre cable. Susceptibility artefacts and RF noise were introduced into MR images by the US imaging system. RF noise was minimised by using aluminium foil to shield the transducer. A study of MR and B-mode US image signal-to-noise ratio (SNR) as a function of transducer-phantom separation was performed using a gel phantom. This revealed that a 4 cm separation between the phantom surface and the transducer was sufficient to minimise the effect of the susceptibility artefact in MR images. MR-US imaging was demonstratedin vivowith the aid of a 2 mm VeroWhite 3D-printed spherical target placed over the thigh muscle of a rat. The target allowed single-point registration of MR and US images in the axial plane to be performed. The system was subsequently demonstrated as a tool for the targeting and visualisation of high intensity focused ultrasound exposure in the rat thigh muscle.


2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Caroline J. Shaw ◽  
Ian Rivens ◽  
John Civale ◽  
Kimberley J. Botting ◽  
Gail ter Haar ◽  
...  

RSC Advances ◽  
2018 ◽  
Vol 8 (9) ◽  
pp. 4514-4524 ◽  
Author(s):  
Minghua Yao ◽  
Ming Ma ◽  
Huixiong Xu ◽  
Xiaoxia Pan ◽  
Guang Xu ◽  
...  

A nanometer-sized inor-ganic/organic hybrid enhancement agent is constructed for photoacoustic imaging-guided high intensity focused ultrasound therapy.


2010 ◽  
Vol 183 (4S) ◽  
Author(s):  
Robert Ritchie ◽  
Carmela De Santo ◽  
Ramon Arscott ◽  
Thomas Leslie ◽  
Vincenzo Cerundulo ◽  
...  

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