Stimulation of the cochlea using green laser light

2009 ◽  
Author(s):  
G. I. Wenzel ◽  
S. Balster ◽  
H. H. Lim ◽  
K. Zhang ◽  
U. Reich ◽  
...  
2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Quanbao Gu ◽  
Lina Wang ◽  
Fang Huang ◽  
Wolfgang Schwarz

Low-level laser irradiation of visible light had been introduced as a medical treatment already more than 40 years ago, but its medical application still remains controversial. Laser stimulation of acupuncture points has also been introduced, and mast-cells degranulation has been suggested. Activation of TRPV ion channels may be involved in the degranulation. Here, we investigated whether TRPV1 could serve as candidate for laser-induced mast cell activation. Activation of TRPV1 by capsaicin resulted in degranulation. To investigate the effect of laser irradiation on TRPV1, we used theXenopusoocyte as expression and model system. We show that TRPV1 can functionally be expressed in the oocyte by (a) activation by capsaicin (K1/2= 1.1 μM), (b) activation by temperatures exceeding 42°C, (c) activation by reduced pH (from 7.4 to 6.2), and (d) inhibition by ruthenium red. Red (637 nm) as well as blue (406 nm) light neither affected membrane currents in oocytes nor did it modulate capsaicin-induced current. In contrast, green laser light (532 nm) produced power-dependent activation of TRPV1. In conclusion, we could show that green light is effective at the cellular level to activate TRPV1. To which extend green light is of medical relevance needs further investigation.


1988 ◽  
Vol 65 (4) ◽  
pp. 1895-1901 ◽  
Author(s):  
L. B. Wong ◽  
I. F. Miller ◽  
D. B. Yeates

The ciliated epithelium of the mammalian trachea separates the neurohumoral milieu of the tissue from that of the environment of the airway lumen. To determine whether specific autonomic receptors regulating ciliary beat frequency (CBF) were located on mucosal or serosal sides, we measured CBF by heterodyne mode correlation analysis laser light scattering in bovine tracheal tissues mounted in a two-sided chamber. A beta 2-adrenergic agonist, fenoterol, at 10(-7) M, stimulated serosal CBF from 7.9 +/- 1.3 to 20.2 +/- 5.8 Hz (P less than 0.01) and mucosal CBF from 6.6 +/- 0.9 to 14.7 +/- 4.6 Hz (P less than 0.01). A muscarinic cholinergic agonist, methacholine, at 10(-7) M, increased mucosal CBF from 8.4 +/- 1.0 to 19.5 +/- 5.5 Hz (P less than 0.01) and serosal CBF from 8.0 +/- 0.9 to 15.4 +/- 5.0 Hz (P less than 0.01). The differences in stimulation of CBF on the mucosal and serosal sides between fenoterol and methacholine were significant (P less than 0.01). Studies in which these autonomic agonist stimulating effects were inhibited by their respective antagonists, propranolol and atropine sulfate, demonstrated that CBF can be regulated independently by mediators both in the submucosa and within the mucus lining.


2017 ◽  
Vol 31 (2) ◽  
pp. 115-119 ◽  
Author(s):  
Rukiye Aydin ◽  
Merve Ozbek ◽  
Mustafa Ozsutcu ◽  
Fevzi Senturk
Keyword(s):  

2020 ◽  
Vol 10 (3) ◽  
pp. 1189 ◽  
Author(s):  
Mohammed Hasan ◽  
Marlia Mohd Hanafiah ◽  
Ziad Aeyad Taha ◽  
Intsar H. H. AlHilfy ◽  
Mohd Nizam Mohd Said

This study aims to compare the effects of different laser wavelengths, exposure times, and low-power-intensity laser irradiation on maize seeds. Seeds were exposed to He–Ne (632.8 nm) red laser, Nd:YAG second-harmonic-generation (532 nm) green laser, and diode (410 nm) blue laser. Four different exposure times (45, 65, 85, and 105 s) with different intensity (2 and 4 mW/cm2), for each laser were tested. Phenology and yield components (plant height, leaf area, number of rows per ear, seed yield, harvest index, yield efficiency, and grain weight) were determined. The experiment was conducted in a randomized complete block design with three replications. Plant height was found comparatively high in blue laser light—211 cm at 85 s. Blue and green laser lights showed significant increases in the number of rows per ear to 39.1 at 85 s and 45 at 65 s, respectively, compared to the control of 36 rows/ear. The order of seed yield was blue (7003.4 kg/ha) > green (6667.8 kg/ha) > red (6568.01 t/ha) based on different exposure times of 85 s, 85 s, and 105 s, respectively, compared to the control of 6.9 kg/ha. The findings indicate the possibility of using blue laser light to manipulate the growth and yield of maize.


2009 ◽  
Vol 14 (4) ◽  
pp. 044007 ◽  
Author(s):  
Gentiana I. Wenzel ◽  
Sven Balster ◽  
Kaiyin Zhang ◽  
Hubert H. Lim ◽  
Uta Reich ◽  
...  
Keyword(s):  

2021 ◽  
Vol 24 (4) ◽  
pp. 43-53
Author(s):  
N. E. Gorbatova ◽  
D. A. Safin ◽  
E. N. Gasanova ◽  
A. A. Sirotkin ◽  
G. P. Kuzmin ◽  
...  

Rationale. The existing techniques for treating skin capillary angiodysplasias, including «laser» photodestruction, are not effective enough and often cause undesirable thermal damage and cicatricial deformities of the skin. Thus, the effective removal of this vascular pathology is still relevant and requires further solution.Purpose. To study the nature of thermal injuries and wound regenerative processes after «green» laser irradiation with wavelength 525 nm so as to find out if it may be used for selective photodestruction of subepithelial pathological vascular structures, including angiodysplasias of skin capillaries.Material and Methods. Scallops of alive white chickens were taken as a biological model of vascular structures for in vivo studies. An experimental solid-state laser generating «green» light with wavelength 525 nm was used. This laser light has similar peaks of the absorption coefficient of hemoglobin and oxyhemoglobin which are found in skin capillaries. Features of damage and dynamics of regenerative process in the irradiated area were studied at the model of vascular structures using findings of morphological macroscopic and histological examinations.Results. Findings of the present experimental trial have inspired that selective photodestruction of subepithelial vascular structures of scallops is possible with minimal damage to the epithelium, including growth zones. In irradiated areas, one could see whitening and smoothing of the surface due to closure of vessel lumens in the subepithelial zone and formation of collagenosis layer there, as well as epithelialization of wound surface in physiological terms without any formation of cicatricial deformation of the skin.Conclusion. The selective effect of 525 nm «green» laser light at subepithelial vascular structures with minimal skin damage has been confirmed. It opens a way to apply this light for selective photodestruction of capillary angiodysplasias of the skin with good clinical and esthetic outcomes.


ChemPhysChem ◽  
2014 ◽  
Vol 15 (18) ◽  
pp. 3882-3882 ◽  
Author(s):  
Katarzyna M. Marzec ◽  
David Perez-Guaita ◽  
Marleen de Veij ◽  
Don McNaughton ◽  
Malgorzata Baranska ◽  
...  

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