Rapid prototyping of multi-level polydimethylsiloxane-based microfluidic devices

2008 ◽  
Author(s):  
Wai Chye Cheong ◽  
Yoke Kong Kuan ◽  
Mo-Huang Li ◽  
Jackie Y. Ying
Keyword(s):  
Rapid Prototyping ◽  
Microfluidic Devices ◽  
Multi Level

scholarly journals Safe and cost-effective rapid-prototyping of multilayer PMMA microfluidic devices

2016 ◽  
Vol 20 (12) ◽  
Author(s):  
Antonio Liga ◽  
Jonathan A. S. Morton ◽  
Maïwenn Kersaudy-Kerhoas
Keyword(s):  
Rapid Prototyping ◽  
Microfluidic Devices ◽  
Cost Effective

scholarly journals Design of HIL for Multi-Level Inverter Using Zynq-7000 Platform – Part 1

2017 ◽  
Vol 61 (3) ◽  
pp. 264 ◽  
Author(s):  
Balázs Farkas ◽  
Károly Veszprémi
Keyword(s):  
Rapid Prototyping ◽  
Software Design ◽  
System Modeling ◽  
Electronic Devices ◽  
Electronic System ◽  
Power Electronic ◽  
Hardware In The Loop ◽  
Model Based ◽  
New Approaches ◽  
Multi Level

Development of power electronic devices requires multi -disciplined engineering activities. These cover the thermal, electrical and software design. Due to this design complexity rapid prototyping methods and model-based design are becoming more and more important in the R&D projects in this field. In case of the multi-level inverter based drives the strict reliability requirements make the aforementioned new approaches more attractive. This article is the first part of the series which introduces the application of the model based design and Hardware-in-the-Loop (HIL) tools through the modeling of a Cellular H-Bridge inverter (CHB). This article focuses on the power electronic system modeling and verification. The model of the CHB is implemented and verified in Matlab.

scholarly journals Recent advances in nonbiofouling PDMS surface modification strategies applicable to microfluidic technology

TECHNOLOGY ◽  
2017 ◽  
Vol 05 (01) ◽  
pp. 1-12 ◽  
Author(s):  
Aslihan Gokaltun ◽  
Martin L. Yarmush ◽  
Ayse Asatekin ◽  
O. Berk Usta
Keyword(s):  
Rapid Prototyping ◽  
Biomedical Applications ◽  
Gas Permeability ◽  
Low Cost ◽  
Microfluidic Devices ◽  
Mature Stage ◽  
Major Drawback ◽  
Pdms Surface ◽  
Recent Advances ◽  
Hydrophobic Recovery

In the last decade microfabrication processes including rapid prototyping techniques have advanced rapidly and achieved a fairly mature stage. These advances have encouraged and enabled the use of microfluidic devices by a wider range of users with applications in biological separations and cell and organoid cultures. Accordingly, a significant current challenge in the field is controlling biomolecular interactions at interfaces and the development of novel biomaterials to satisfy the unique needs of the biomedical applications. Poly(dimethylsiloxane) (PDMS) is one of the most widely used materials in the fabrication of microfluidic devices. The popularity of this material is the result of its low cost, simple fabrication allowing rapid prototyping, high optical transparency, and gas permeability. However, a major drawback of PDMS is its hydrophobicity and fast hydrophobic recovery after surface hydrophilization. This results in significant nonspecific adsorption of proteins as well as small hydrophobic molecules such as therapeutic drugs limiting the utility of PDMS in biomedical microfluidic circuitry. Accordingly, here, we focus on recent advances in surface molecular treatments to prevent fouling of PDMS surfaces towards improving its utility and expanding its use cases in biomedical applications.

scholarly journals Negligible-cost microfluidic device fabrication using 3D-printed interconnecting channel scaffolds

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0245206
Author(s):  
Harry Felton ◽  
Robert Hughes ◽  
Andrea Diaz-Gaxiola
Keyword(s):  
Rapid Prototyping ◽  
Point Of Care ◽  
Low Cost ◽  
Microfluidic Channel ◽  
Microfluidic Devices ◽  
Device Fabrication ◽  
Appropriate Technology ◽  
Channel Cross Section ◽  
Microfluidic Systems ◽  
3D Printed

This paper reports a novel, negligible-cost and open-source process for the rapid prototyping of complex microfluidic devices in polydimethylsiloxane (PDMS) using 3D-printed interconnecting microchannel scaffolds. These single-extrusion scaffolds are designed with interconnecting ends and used to quickly configure complex microfluidic systems before being embedded in PDMS to produce an imprint of the microfluidic configuration. The scaffolds are printed using common Material Extrusion (MEX) 3D printers and the limits, cost & reliability of the process are evaluated. The limits of standard MEX 3D-printing with off-the-shelf printer modifications is shown to achieve a minimum channel cross-section of 100×100 μm. The paper also lays out a protocol for the rapid fabrication of low-cost microfluidic channel moulds from the thermoplastic 3D-printed scaffolds, allowing the manufacture of customisable microfluidic systems without specialist equipment. The morphology of the resulting PDMS microchannels fabricated with the method are characterised and, when applied directly to glass, without plasma surface treatment, are shown to efficiently operate within the typical working pressures of commercial microfluidic devices. The technique is further validated through the demonstration of 2 common microfluidic devices; a fluid-mixer demonstrating the effective interconnecting scaffold design, and a microsphere droplet generator. The minimal cost of manufacture means that a 5000-piece physical library of mix-and-match channel scaffolds (100 μm scale) can be printed for ~$0.50 and made available to researchers and educators who lack access to appropriate technology. This simple yet innovative approach dramatically lowers the threshold for research and education into microfluidics and will make possible the rapid prototyping of point-of-care lab-on-a-chip diagnostic technology that is truly affordable the world over.

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