Introduction of a new laser-scalpel for partial kidney resection based on 1.94 micrometer fiber laser system: initial in vivo-data

2009 ◽  
Author(s):  
Sönke Tedsen ◽  
Dirk Theisen-Kunde ◽  
Christian Doehn ◽  
Ingo Kausch ◽  
Dieter Jocham
Keyword(s):  
Fiber Laser ◽  
Laser System ◽  
Partial Kidney Resection ◽  
Laser Scalpel ◽  
Kidney Resection

Partial porcine kidney resection in vivo using a 1.92 μm fiber laser system

2009 ◽  
Author(s):  
Dirk Theisen-Kunde ◽  
Sönke Tedsen ◽  
Veit Danicke ◽  
Ralf Brinkmann
Keyword(s):  
Fiber Laser ◽  
Laser System ◽  
Porcine Kidney ◽  
Kidney Resection

Partial kidney resection based on 1.94μm fiber laser system

2007 ◽  
Author(s):  
D. Theisen-Kunde ◽  
S. Tedsen ◽  
K. Herrmann ◽  
V. Danicke ◽  
R. Brinkmann
Keyword(s):  
Fiber Laser ◽  
Laser System ◽  
Partial Kidney Resection ◽  
Kidney Resection

In Vivo and Ex Vivo characterization of a novel Er fiber laser system for fractional treatment of soft oral tissues

2018 ◽  
Author(s):  
Ksenia V. Shatilova ◽  
Georgii A. Aloian ◽  
Ilya V. Yaroslavsky ◽  
Gregory B. Altshuler ◽  
Maria Karabut ◽  
...  
Keyword(s):  
Fiber Laser ◽  
Ex Vivo ◽  
Laser System

Comparison between a 1.92-μm fiber laser and a standard HF-dissection device for nephron-sparing kidney resection in a porcine in vivo study

2011 ◽  
Vol 26 (4) ◽  
pp. 509-514 ◽  
Author(s):  
Dirk Theisen-Kunde ◽  
Sönke Tedsen ◽  
Christian Doehn ◽  
Dieter Jocham ◽  
Ingo Kausch von Schmeling
Keyword(s):  
Fiber Laser ◽  
In Vivo Study ◽  
Nephron Sparing ◽  
Kidney Resection

Laser-Scalpel for Kidney Resection Based on 1,94 µm Fibre Laser System

2007 ◽  
pp. 431-434 ◽  
Author(s):  
Dirk Theisen-Kunde ◽  
Söhnke Tedsen ◽  
Veit Danicke ◽  
Robert Keller ◽  
Ralf Brinkmann
Keyword(s):  
Laser System ◽  
Fibre Laser ◽  
Laser Scalpel ◽  
Kidney Resection

scholarly journals Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks

2007 ◽  
Vol 177 (2) ◽  
pp. 219-229 ◽  
Author(s):  
Naoya Uematsu ◽  
Eric Weterings ◽  
Ken-ichi Yano ◽  
Keiko Morotomi-Yano ◽  
Burkhard Jakob ◽  
...  
Keyword(s):  
Kinase Activity ◽  
Laser System ◽  
Double Strand Breaks ◽  
Dependent Manner ◽  
Dna Double Strand Breaks ◽  
End Joining ◽  
Dsb Repair ◽  
Strand Breaks ◽  
Dna Ends

The DNA-dependent protein kinase catalytic subunit (DNA-PKCS) plays an important role during the repair of DNA double-strand breaks (DSBs). It is recruited to DNA ends in the early stages of the nonhomologous end-joining (NHEJ) process, which mediates DSB repair. To study DNA-PKCS recruitment in vivo, we used a laser system to introduce DSBs in a specified region of the cell nucleus. We show that DNA-PKCS accumulates at DSB sites in a Ku80-dependent manner, and that neither the kinase activity nor the phosphorylation status of DNA-PKCS influences its initial accumulation. However, impairment of both of these functions results in deficient DSB repair and the maintained presence of DNA-PKCS at unrepaired DSBs. The use of photobleaching techniques allowed us to determine that the kinase activity and phosphorylation status of DNA-PKCS influence the stability of its binding to DNA ends. We suggest a model in which DNA-PKCS phosphorylation/autophosphorylation facilitates NHEJ by destabilizing the interaction of DNA-PKCS with the DNA ends.

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