Subcellular real-time in vivo imaging of intralymphatic and intravascular cancer-cell trafficking

2008 ◽  
Author(s):  
M. McElroy ◽  
K. Hayashi ◽  
S. Kaushal ◽  
M. Bouvet ◽  
Robert M. Hoffman
2009 ◽  
Vol 3 (4) ◽  
pp. 351-354 ◽  
Author(s):  
Paul Timpson ◽  
Alan Serrels ◽  
Marta Canel ◽  
Margaret C. Frame ◽  
Valerie G. Brunton ◽  
...  

2016 ◽  
Vol 78 (1) ◽  
pp. 156-164 ◽  
Author(s):  
Xiaoyu Jiang ◽  
Hua Li ◽  
Jingping Xie ◽  
Eliot T. McKinley ◽  
Ping Zhao ◽  
...  

APOPTOSIS ◽  
2010 ◽  
Vol 16 (2) ◽  
pp. 198-207 ◽  
Author(s):  
Matteo Scabini ◽  
Fabio Stellari ◽  
Paolo Cappella ◽  
Sara Rizzitano ◽  
Gemma Texido ◽  
...  

2021 ◽  
Vol 103-B (7 Supple B) ◽  
pp. 9-16
Author(s):  
William J. Hadden ◽  
Mazen Ibrahim ◽  
Mariam Taha ◽  
Kerstin Ure ◽  
Yun Liu ◽  
...  

Aims The aims of this study were to develop an in vivo model of periprosthetic joint infection (PJI) in cemented hip hemiarthroplasty, and to monitor infection and biofilm formation in real-time. Methods Sprague-Dawley rats underwent cemented hip hemiarthroplasty via the posterior approach with pre- and postoperative gait assessments. Infection with Staphylococcus aureus Xen36 was monitored with in vivo photoluminescent imaging in real-time. Pre- and postoperative gait analyses were performed and compared. Postmortem micro (m) CT was used to assess implant integration; field emission scanning electron microscopy (FE-SEM) was used to assess biofilm formation on prosthetic surfaces. Results All animals tolerated surgery well, with preservation of gait mechanics and weightbearing in control individuals. Postoperative in vivo imaging demonstrated predictable evolution of infection with logarithmic signal decay coinciding with abscess formation. Postmortem mCT qualitative volumetric analysis showed high contact area and both cement-bone and cement-implant interdigitation. FE-SEM revealed biofilm formation on the prosthetic head. Conclusion This study demonstrates the utility of a new, high-fidelity model of in vivo PJI using cemented hip hemiarthroplasty in rats. Inoculation with bioluminescent bacteria allows for non-invasive, real-time monitoring of infection. Cite this article: Bone Joint J 2021;103-B(7 Supple B):9–16.


2006 ◽  
Vol 1 (1) ◽  
pp. 476-485 ◽  
Author(s):  
Blandine Franke-Fayard ◽  
Andrew P Waters ◽  
Chris J Janse

2006 ◽  
Vol 66 (8) ◽  
pp. 4208-4214 ◽  
Author(s):  
Kensuke Yamauchi ◽  
Meng Yang ◽  
Ping Jiang ◽  
Mingxu Xu ◽  
Norio Yamamoto ◽  
...  

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Rhiannon P. Murrie ◽  
Freda Werdiger ◽  
Martin Donnelley ◽  
Yu-wei Lin ◽  
Richard P. Carnibella ◽  
...  

2003 ◽  
Vol 28 (19) ◽  
pp. 1745 ◽  
Author(s):  
Maciej Wojtkowski ◽  
Tomasz Bajraszewski ◽  
Piotr Targowski ◽  
Andrzej Kowalczyk

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