Automated scoring system of standard uptake value for torso FDG-PET images

2008 ◽  
Author(s):  
Takeshi Hara ◽  
Tatsunori Kobayashi ◽  
Kazunao Kawai ◽  
Xiangrong Zhou ◽  
Satoshi Itoh ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Scoring System ◽  
Standard Uptake Value ◽  
Automated Scoring

Abstract 35: DVT Inflammation Assessed by 18F-FDG-PET/CT Predicts Subsequent Vein Wall Scarring

2016 ◽  
Vol 36 (suppl_1) ◽  
Author(s):  
Chase W Kessinger ◽  
Ahmed Tawakol ◽  
Gregory R Wojtkiewicz ◽  
Peter K Henke ◽  
Ralph Weissleder ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Vena Cava ◽  
Standard Uptake Value ◽  
Vein Wall ◽  
Positron Emission ◽  
Pet Ct ◽  
18F Fdg ◽  
The Right ◽  
Fdg Pet Ct

Objective: While venous thrombosis (VT)-induced inflammation facilitates thrombus resolution, inflammation causes vein wall scarring (VWS). Recently, statins have shown to improve VT resolution and reduce VT inflammatory components. In this study, we hypothesized that early VT inflammation detected by 18F-FDG positron emission tomography/computed tomography (PET/CT) could predict subsequent late stage VWS, and would be attenuated by statin therapy. Methods: Stasis VT was induced in 8-12 week old male C57BL/6 mice (n=31) in either the right jugular vein (n=13) or inferior vena cava (IVC,n=18). Animals in the IVC VT cohort were randomized to statin (n=8) or control (n=10) treatment. Statin, rosuvastatin (5mg/kg), was administered by oral gavage, daily starting 24 hours prior to VT induction; control mice received saline. All mice underwent survival FDG-PET/CT venography imaging on day 2. FDG inflammation signals (standard uptake value=SUV) were measured in the thrombosed vein and compared to the sham-operated venous segments or treatment control. On day 14, mice were sacrificed and VT tissue was resected. Picrosirius red staining allowed measurement of collagen and vein wall thickness in VT sections. Results: FDG-PET/CT at day 2 revealed increased inflammation signal activity in jugular VT (SUV 1.43 ± 0.3 VT vs. 0.81 ± 0.3 contralateral vein, p<0.0001). Statin-treated mice showed a trend of decreased inflammation signal at day 2 in the IVC VT models (SUV 1.02 ± 0.1 statin VT vs. 1.42 ± 0.2 control VT, p=0.07). Day 14 histological analysis revealed significantly reduced vein wall injury in statin-treated animals (thickness, 32±9.4 μm statin; vs. 56.2±14.7 μm control, p=0.02). Day 2 FDG-PET inflammation in VT correlated positively with the magnitude of day 14 VWS (jugular VT, Spearman r=0.62, p=0.02; IVC VT r=0.74, p<0.001, respectively). Conclusions: Quantitative FDG-PET/CT imaging demonstrates that early in vivo VT inflammation predicts subsequent VWS, a driver of post-thrombotic syndrome (PTS). The overall findings strengthen: (i) the link between inflammation and PTS; (ii) the translational potential of FDG-PET inflammation to predict VWS and PTS; and (iii) the concept that statins and other anti-inflammatory therapies could reduce VWS and PTS.

scholarly journals A Study of Applying Automated Assessment in Teaching College English Writing Based on Juku Correction Network

2019 ◽  
Vol 14 (11) ◽  
pp. 19
Author(s):  
Yusheng Wang
Keyword(s):  
Scoring System ◽  
Teaching Model ◽  
Network Technology ◽  
Automated Scoring ◽  
Teaching Mode ◽  
College English ◽  
English Writing ◽  
Writing Motivation ◽  
Teaching College ◽  
Writing Course

With the continuous advancement of modern network technology, the drawbacks of the tradition-al English writing course teaching mode have become increasingly prominent, and the automated scoring system has gradually been used in the writing course. This paper proposes a college English writing teaching model based on Juku Correction Network, and conducts empirical re-search on the use of Juku Correction Network in college English writing teaching. The research results show that the teaching mode based on Juku Correction Network can effectively improve the overall level of students' English writing, and stimulate students' English writing motivation.

scholarly journals Diagnostic Performance of Simultaneous [18F]-FDG PET/MR for Assessing Endoscopically Active Inflammation in Patients with Ulcerative Colitis: A Prospective Study

2020 ◽  
Vol 9 (8) ◽  
pp. 2474
Author(s):  
Jost Langhorst ◽  
Lale Umutlu ◽  
Benedikt Michael Schaarschmidt ◽  
Johannes Grueneisen ◽  
Aydin Demircioglu ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Fdg Pet ◽  
Diagnostic Performance ◽  
Standard Uptake Value ◽  
Mr Enterography ◽  
Metabolic Conditions ◽  
18F Fdg ◽  
A Prospective Study ◽  
Active Inflammation ◽  
Bowel Segments

Background: To investigate the diagnostic performance of simultaneous 18F-fluoro-deoxyglucose ([18F]-FDG) PET/MR enterography in assessing and grading endoscopically active inflammation in patients with ulcerative colitis. Methods: 50 patients underwent PET/MR 24 h before ileocolonoscopy. Inflammatory activities of bowel segments were evaluated with both Mayo endoscopic subscore and Nancy histologic index. MR, DWI (Diffusion-weighted imaging) and PET were utilized as qualitative parameters for detecting endoscopically active inflammation. SUVmaxQuot in each segment (maximum of standard uptake value relative to liver) was calculated to quantify inflammation. Results: In the study arm without bowel purgation, combined reading of PET and MR resulted in significantly increased specificity against each submodality alone (0.944 vs. 0.82 for MR and 0.843 for PET, p < 0.05) and highest overall accuracy. In the study arm with bowel purgation, the significantly lower specificity of PET (0.595) could be markedly improved by a combined reading of PET and MR. Metabolic conditions in bowel segments with both endoscopic and histological remission were significantly lower than in segments with endoscopic remission but persistent microscopic inflammation (SUVmaxQuot 0.719 vs. 0.947, p < 0.001). SUVmaxQuot correlated highly with Mayo endoscopic subscore (ρ = 0.718 and 0.606) and enabled grading of inflammatory activity. Conclusions: Simultaneous [18F]-FDG PET/MR may be considered as an alternative to endoscopy in clinical trials.

FDG-PET Predicts Response to Fractionated Radioimmunotherapy with 90Y-Epratuzumab Anti-CD22 MAB in Patients with NHL.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 4782-4782
Author(s):  
Caroline Bodet-Milin ◽  
Caroline Rousseau ◽  
Loic Campion ◽  
Catherine Ansquer ◽  
Benoit Dupas ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Fdg Pet ◽  
Residual Disease ◽  
Complete Response ◽  
Standard Uptake Value ◽  
Ct Scans ◽  
Fdg Uptake ◽  
Focal Uptake ◽  
Progression Of Disease ◽  
Conventional Ct

Abstract Objective: To evaluate FDG-PET imaging for early prediction of response in patients with NHL treated with fractionated radioimmunotherapy (RIT). Methods: Ten patients from a larger ongoing, multicenter, Phase I/II trial of fractionated RIT (2–3 injections 1-week apart of humanized anti-CD22 antibody, epratuzumab, labeled with 90Y) underwent FDG-PET imaging together with CT scans of the chest, abdomen and pelvis at baseline and 6 weeks post-RIT, and then every 3 months until progression. Tumor responses evaluated from CT images were classified using Cheson lymphoma criteria as complete response (CR), unconfirmed CR (CRu), partial response (PR), stable disease (SD) or progression of disease (PD). PET images were evaluated for abnormal focal uptake visually, using standard uptake value (SUV) quantitation, and were classified as CR when all tumor foci disappeared, incomplete response (IR) when FDG uptake decreased with persistent foci, or PD when FDG uptake increased or new foci developed. Results: A total of 36 paired imaging studies were obtained post RIT (including 3 patients after retreatment) and evaluated as CR (n=7), CRu (n=14), SD (n=5) or PD (n=10) by CT and CR (n= 13), IR (n= 8) or PD (n=15) by PET. Of the 14 studies evaluated as CRu by CT, 7 were definitively evaluated by PET as CR, 3 as IR, and 4 as PD. Of 22 studies not evaluated as CRu by CT, PET identified PD in one case evaluated as CR by CT and was otherwise concordant with CT (10 PD/PD, 6 CR/CR, 5 SD/IR). Among PET images acquired at 6 weeks post-RIT, the mean time-to-progression (TTP) was 9.6 months for negative PET images (CR) compared to 4.1 months for positive PET findings (IR, PD) (P=0.16). Conclusion: In our study, FDG-PET appeared superior to conventional CT in evaluating response to fractionated RIT. For CT scans frequently evaluated as CRu, PET resolved uncertainty regarding residual disease, and PET images acquired 6 weeks after RIT predicted later relapse.

scholarly journals MP80-09 2-18FLUORO-DEOXY-D-GLUCOSE POSITRON EMISSION TOMOGRAPHY (FDG-PET) IN SEMINOMA: IS AN OBJECTIVE SCORING SYSTEM USEFUL?

2017 ◽  
Vol 197 (4S) ◽  
Author(s):  
Clint Cary ◽  
Antoin Dougwali ◽  
Ryan Zukerman ◽  
Costantine Albany ◽  
Mark Tann ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Fdg Pet ◽  
Scoring System ◽  
Emission Tomography ◽  
Positron Emission

EP-1203 PREDICTION OF EARLY RESPONSE TO RADIATION THERAPY USING FDG-PET STANDARD UPTAKE VALUE

2012 ◽  
Vol 103 ◽  
pp. S462-S463
Author(s):  
A. Ruiz ◽  
R. D'Ambrosi ◽  
A. Castaño ◽  
R. De Juan ◽  
P. Cotrina ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Fdg Pet ◽  
Standard Uptake Value ◽  
Early Response
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