In vivo microscopic x-ray imaging in rat and mouse using synchrotron radiation

2008 ◽  
Author(s):  
Keiji Umetani ◽  
Takashi Sakurai ◽  
Takeshi Kondoh
IUCrJ ◽  
2020 ◽  
Vol 7 (5) ◽  
pp. 793-802 ◽  
Author(s):  
Feixiang Wang ◽  
Panting Zhou ◽  
Ke Li ◽  
Muyassar Mamtilahun ◽  
Yaohui Tang ◽  
...  

Early stages of diseases, including stroke, hypertension, angiogenesis of tumours, spinal cord injuries, etc., are closely associated with the lesions of microvasculature. Rodent models of human vascular diseases are extensively used for the preclinical investigation of the disease evolution and therapy with synchrotron radiation. Therefore, non-invasive and in vivo X-ray imaging with high sensitivity and clarity is desperately needed to visualize the microvessels in live-animal models. Contrast agent is essential for the in vivo X-ray imaging of vessels and angiomatous tissue. Because of the non-rigid motion of adjacent tissues, the short circulation time and the intermittent flow of contrast agents in vessels, it is a great challenge for the traditional X-ray imaging methods to achieve well defined images of microvessels in vivo. In this article, move contrast X-ray imaging (MCXI) based on high-brightness synchrotron radiation is developed to overcome the intrinsic defects in conventional methods. Experiments with live rodents demonstrate the practicability of the MCXI method for sensitive and intact imaging of microvessels in vivo.


2021 ◽  
pp. 1-7
Author(s):  
Brian K. Tanner ◽  
Patrick J. McNally ◽  
Andreas N. Danilewsky

X-ray diffraction imaging (XRDI) (topography) measurements of silicon die warpage within fully packaged commercial quad-flat no-lead devices are described. Using synchrotron radiation, it has been shown that the tilt of the lattice planes in the Analog Devices AD9253 die initially falls, but after 100 °C, it rises again. The twist across the die wafer falls linearly with an increase in temperature. At 200 °C, the tilt varies approximately linearly with position, that is, displacement varies quadratically along the die. The warpage is approximately reversible on cooling, suggesting that it has a simple paraboloidal form prior to encapsulation; the complex tilt and twisting result from the polymer setting process. Feasibility studies are reported, which demonstrate that a divergent beam and quasi-monochromatic radiation from a sealed X-ray tube can be used to perform warpage measurements by XRDI in the laboratory. Existing tools have limitations because of the geometry of the X-ray optics, resulting in applicability only to simple warpage structures. The necessary modifications required for use in situations of complex warpage, for example, in multiple die interconnected packages are specified.


2010 ◽  
Vol 18 (4) ◽  
pp. 429-441 ◽  
Author(s):  
A. Rack ◽  
F. Garcia-Moreno ◽  
C. Schmitt ◽  
O. Betz ◽  
A. Cecilia ◽  
...  

2018 ◽  
Vol 89 (10) ◽  
pp. 10G126 ◽  
Author(s):  
N. R. Pereira ◽  
A. T. Macrander ◽  
C. Stoeckl ◽  
E. O. Baronova

2018 ◽  
Vol 24 (S2) ◽  
pp. 542-543
Author(s):  
Kai zhang ◽  
Fang Ren ◽  
Xuelong Wang ◽  
Enyuan Hu ◽  
Xiao-Qing Yang ◽  
...  

2019 ◽  
Vol 307 ◽  
pp. 282-291 ◽  
Author(s):  
Regine Gradl ◽  
Martin Dierolf ◽  
Lin Yang ◽  
Lorenz Hehn ◽  
Benedikt Günther ◽  
...  

1994 ◽  
Vol 38 ◽  
pp. 615-624
Author(s):  
Bradley E. Patt ◽  
Jan S. Iwanczyk ◽  
Martin P. Tornai ◽  
Craig S. Levin ◽  
Edward J. Hoffman

Abstract A nineteen element mercuric iodide (HgI2) detector array has been developed in order to investigate the potential of using this technology for in-vivo x-ray and gamma-ray imaging. A prototype cross-grid detector array was constructed with hexagonal pixels of 1.9 mm diameter (active area = 3.28 mm2) and 0.2 mm thick septa. The overall detector active area is roughly 65 mm2. A detector thickness of 1.2 mm was used to achieve about 100% efficiency at 60 keV and 67% efficiency at 140 keV The detector fabrication, geometry and structure were optimized for charge collection and to minimize crosstalk between elements. A section of a standard high resolution cast-lead gamma-camera collimator was incorporated into the detector to provide collimation matching the discrete pixel geometry. Measurements of spectral and spatial performance of the array were made using 241-Am and 99m-Tc sources. These measurements were compared with similar measurements made using an optimized single HgI2 x-ray detector with active area of about 3 mm2 and thickness of 500 μm.


Author(s):  
Kaye Morgan ◽  
Regine Gradl ◽  
Martin Dierolf ◽  
Christoph Jud ◽  
Benedikt Günther ◽  
...  

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