Development of high yielding photonic light delivery system for photodynamic therapy of esophageal carcinomas

Author(s):  
Amaranath Premasiri ◽  
Gemunu Happawana ◽  
Arye Rosen
2005 ◽  
Vol 95 (9) ◽  
pp. 1237-1244 ◽  
Author(s):  
Jerzy Jankun ◽  
Rick W. Keck ◽  
Ewa Skrzypczak-Jankun ◽  
Lothar Lilge ◽  
Steven H. Selman

1993 ◽  
Vol 8 (4) ◽  
pp. 253-257 ◽  
Author(s):  
S. F. Purkiss ◽  
R. Dean ◽  
J. T. Allardice ◽  
M. Grahn ◽  
N. S. Williams

1999 ◽  
Vol 26 (8) ◽  
pp. 1552-1558 ◽  
Author(s):  
David A. Bellnier ◽  
Leroy M. Wood ◽  
William R. Potter ◽  
Kenneth R. Weishaupt ◽  
Allan R. Oseroff

2010 ◽  
Vol 3 (5-6) ◽  
pp. 347-355 ◽  
Author(s):  
Floor van Zaane ◽  
Devendiran Subbaiyan ◽  
Angelique van der Ploeg-van den Heuvel ◽  
Henriëtte S. de Bruijn ◽  
Eduardo Margallo Balbas ◽  
...  

Author(s):  
Amaranath Premasiri ◽  
Gemunu Happawana ◽  
Gary Evans ◽  
Arye Rosen

Photodynamic therapy (PDT) is a minimally invasive treatment with high effectiveness in the management of cancer of the upper gastrointestinal tract. A higher mortality rate associated with surgery and the higher morbidity in the older age group both make PDT a better treatment method for the treatment of esophageal cancer [1–3]. However, limitations in the best docimetry protocols performance of PDT are due to ineffectiveness of the light delivery and in the unavailability of sufficient oxygen required for singlet oxygen generation to bring cellular death [4–7]. The Introduction of an inexpensive high power semiconductor diode lasers for the light delivery system makes PDT efficient, low cost and portable [8–10]. However, the metallic water cooling systems used in the existing semiconductor cooling designs make those systems non-flexible and cumbersome in size [9].


2020 ◽  
Vol 10 (12) ◽  
pp. 4304
Author(s):  
Matthieu Zellweger ◽  
Ying Xiao ◽  
Manish Jain ◽  
Marie-Noëlle Giraud ◽  
Andreas Pitzschke ◽  
...  

Although the versatility of photodynamic therapy (PDT) is well established, the technical aspects of light delivery systems vary significantly depending on the targeted organ. This article describes the optical properties of a light and drug delivery system (catheter and light diffuser) suitable for intra-arterial PDT by using a planar imaging goniometer to measure the full radiance longitudinal and angular profiles at the surface of the diffuser at 652 nm. The results show that the system emits almost Lambertian and “top hat” profiles, an interesting feature to determine the light dosimetry in the many vascular applications of PDT.


1998 ◽  
Vol 13 (2) ◽  
pp. 137-142 ◽  
Author(s):  
J.V.E. Roche ◽  
C. Whitehurst ◽  
P. Watt ◽  
J.V. Moore ◽  
N. Krasner

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