Novel techniques for high-resolution functional imaging of trabecular bone

2005 ◽  
Author(s):  
Philipp J. Thurner ◽  
Ralph Muller ◽  
Johannes H. Kindt ◽  
Georg Schitter ◽  
Georg E. Fantner ◽  
...  
Keyword(s):  
High Resolution ◽  
Trabecular Bone ◽  
Functional Imaging

Automatic Prospective Registration of High-Resolution Trabecular Bone Images of the Tibia

2007 ◽  
Vol 35 (11) ◽  
pp. 1924-1931 ◽  
Author(s):  
Janet Blumenfeld ◽  
Julio Carballido-Gamio ◽  
Roland Krug ◽  
Daniel J. Blezek ◽  
Ileana Hancu ◽  
...  
Keyword(s):  
High Resolution ◽  
Trabecular Bone

Heterogeneity of Cortical Breaks in Hand Joints of Patients with Rheumatoid Arthritis and Healthy Controls Imaged by High-resolution Peripheral Quantitative Computed Tomography

2016 ◽  
Vol 43 (10) ◽  
pp. 1914-1920 ◽  
Author(s):  
Andrea Scharmga ◽  
Michiel Peters ◽  
Astrid van Tubergen ◽  
Joop van den Bergh ◽  
Cheryl Barnabe ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Computed Tomography ◽  
High Resolution ◽  
Trabecular Bone ◽  
Quantitative Computed Tomography ◽  
Peripheral Quantitative Computed Tomography ◽  
Healthy Controls ◽  
Poor Prognostic Factor ◽  
Bone Erosions ◽  
Bone Changes

Objective.Conventional radiographs (CR) of the hands are the gold standard for imaging bone erosions. The presence of bone erosions, reflected by the presence of cortical breaks, is a poor prognostic factor in patients with rheumatoid arthritis (RA). The availability of high-resolution peripheral quantitative computed tomography (HR-pQCT) enables detailed investigation of cortical breaks in rheumatic diseases. The aim of this image review is to show HR-pQCT images of the spectrum of cortical breaks with and without underlying trabecular bone changes in metacarpophalangeal (MCP) joints of healthy controls (HC) and patients with RA, with corresponding images on CR and magnetic resonance imaging (MRI).Methods.Second and third MCP joints of 41 patients (of which 10 were early RA with ≤ 2 years and 24 longstanding RA with ≥ 10 years of disease duration) and 38 HC were imaged by CR, MRI, and HR-pQCT (XtremeCT1, Scanco Medical AG). Representative images of the spectrum of cortical breaks were selected.Results.Cortical breaks were found in early and longstanding RA, but also in HC. They were heterogeneous in size, location, and number per joint, with a variety of surrounding cortical and underlying trabecular bone characteristics.Conclusion.Using HR-pQCT images of MCP joints, heterogeneous cortical breaks with and without surrounding trabecular bone changes were found, not only in RA but also in HC. The underlying mechanisms and significance of this spectrum of cortical breaks as found with high 3-D resolution needs further investigation.

scholarly journals Perfusion-based high-resolution functional imaging in the human brain at 7 Tesla

2002 ◽  
Vol 47 (5) ◽  
pp. 903-911 ◽  
Author(s):  
Josef Pfeuffer ◽  
Gregor Adriany ◽  
Amir Shmuel ◽  
Essa Yacoub ◽  
Pierre-Francois Van De Moortele ◽  
...  
Keyword(s):  
High Resolution ◽  
Human Brain ◽  
Functional Imaging ◽  
7 Tesla

Does the Trabecular Bone Structure Depicted by High-Resolution MRI of the Calcaneus Reflect the True Bone Structure?

2001 ◽  
Vol 36 (4) ◽  
pp. 210-217 ◽  
Author(s):  
VOLKER VIETH ◽  
THOMAS M. LINK ◽  
ALBRECHT LOTTER ◽  
THORSTEN PERSIGEHL ◽  
DAVID NEWITT ◽  
...  
Keyword(s):  
High Resolution ◽  
Trabecular Bone ◽  
Bone Structure ◽  
Trabecular Bone Structure ◽  
High Resolution Mri

scholarly journals High-resolution Quantitative Computed Tomography Demonstrates Structural Defects in Cortical and Trabecular Bone in IBD Patients

2016 ◽  
Vol 10 (5) ◽  
pp. 532-540 ◽  
Author(s):  
Judith Haschka ◽  
Simon Hirschmann ◽  
Arnd Kleyer ◽  
Matthias Englbrecht ◽  
Francesca Faustini ◽  
...  
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
Trabecular Bone ◽  
Quantitative Computed Tomography ◽  
Structural Defects

Preparation of On-Axis Cylindrical Trabecular Bone Specimens Using Micro-CT Imaging

2004 ◽  
Vol 126 (1) ◽  
pp. 122-125 ◽  
Author(s):  
Xiang Wang, ◽  
Xiangyi Liu, and ◽  
Glen L. Niebur
Keyword(s):  
Finite Element ◽  
High Resolution ◽  
Coordinate System ◽  
Trabecular Bone ◽  
Cylindrical Specimen ◽  
Longitudinal Axis ◽  
Ct Imaging ◽  
Finite Element Models ◽  
Micro Ct ◽  
Average Deviation

The Orientation of trabecular bone specimens for mechanical testing must be carefully controlled. A method for accurately preparing on-axis cylindrical specimens using high-resolution micro-CT imaging was developed. Sixteen cylindrical specimens were prepared from eight bovine tibiae. High-resolution finite element models were generated from micro-CT images of parallelepipeds and used to determine the principal material coordinate system of each parallelepiped. A cylindrical specimen was then machined with a diamond coring bit. The resulting specimens were scanned again to evaluate the orientation. The average deviation between the principal fabric orientation and the longitudinal axis of the cylindrical specimen was only 4.70±3.11°.

High-Resolution Three-Dimensional-pQCT Images Can Be an Adequate Basis for In-Vivo μFE Analysis of Bone

2000 ◽  
Vol 123 (2) ◽  
pp. 176-183 ◽  
Author(s):  
W. Pistoia ◽  
B. van Rietbergen ◽  
A. Laib ◽  
P. Ru¨egsegger
Keyword(s):  
High Resolution ◽  
Trabecular Bone ◽  
Elastic Properties ◽  
Bone Structure ◽  
Reference Model ◽  
Von Mises Stress ◽  
Micro Ct ◽  
Von Mises

Micro-finite element (μFE) models based on high-resolution images have enabled the calculation of elastic properties of trabecular bone in vitro. Recently, techniques have been developed to image trabecular bone structure in vivo, albeit at a lesser resolution. The present work studies the usefulness of such in-vivo images for μFE analyses, by comparing their μFE results to those of models based on high-resolution micro-CT (μCT) images. Fifteen specimens obtained from human femoral heads were imaged first with a 3D-pQCT scanner at 165 μm resolution and a second time with a μCT scanner at 56 μm resolution. A third set of images with a resolution of 165 μm was created by downscaling the μCT measurements. The μFE models were created directly from these images. Orthotropic elastic properties and the average tissue von Mises stress of the specimens were calculated from six FE-analyses per specimen. The results of the 165 μm models were compared to those of the 56 μm model, which was taken as the reference model. The results calculated from the pQCT-based models, correlated excellent with those calculated from the reference model for both moduli R2>0.95 and for the average tissue von Mises stress R2>0.83. Results calculated from the downscaled micro-CT models correlated even better with those of the reference models (R2>0.99 for the moduli and R2>0.96 for the average von Mises stress). In the case of the 3D-pQCT based models, however, the slopes of the regression lines were less than one and had to be corrected. The prediction of the Poisson’s ratios was less accurate (R2>0.45 and R2>0.67) for the models based on 3D-pQCT and downscaled μCT images respectively). The fact that the results from the downscaled and original μCT images were nearly identical indicates that the need for a correction in the case of the 3D-pQCT measurements was not due to the voxel size of the images but due to a higher noise level and a lower contrast in these images, in combination with the application of a filtering procedure at 165 micron images. In summary: the results of μFE models based on in-vivo images of the 3D-pQCT can closely resemble those obtained from μFE models based on higher resolution μCT system.

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