Application of the standard Hough-transform to high resolution MRI of human trabecular bone to predict mechanical strength

Author(s):  
Holger F. Bohm ◽  
Christoph Rath ◽  
Roberto A. Monetti ◽  
Dirk Muller ◽  
David Newitt ◽  
...  
2001 ◽  
Vol 36 (4) ◽  
pp. 210-217 ◽  
Author(s):  
VOLKER VIETH ◽  
THOMAS M. LINK ◽  
ALBRECHT LOTTER ◽  
THORSTEN PERSIGEHL ◽  
DAVID NEWITT ◽  
...  

2005 ◽  
Vol 46 (3) ◽  
pp. 306-309 ◽  
Author(s):  
B. Ludescher ◽  
P. Martirosian ◽  
S. Lenk ◽  
J. Machann ◽  
F. Dammann ◽  
...  

Purpose: To evaluate the feasibility of high‐resolution magnetic resonance imaging (MRI) of trabecular bone of the wrist at 3 Tesla (3T) in vivo and to assess the potential benefit of the increased resolution for clinical assessment of structural changes in spongy bone. Material and Methods: High‐resolution MRI of the wrist was performed with a whole‐body 3T MR scanner using a dedicated circularly polarized transmit–receive wrist‐coil. Two 3D‐FISP sequences with a spatial resolution of 300×300×300 µm3 in a measuring time of TA = 7:51 min, and 200×200×200 µm3 in TA = 9:33 min were applied. Seven young healthy volunteers and three elderly subjects with suspected osteoporosis were examined. The signal‐to‐noise ratio (SNR) in the optimized setup at 3T was compared to measurements at 1.5T. Results: The images at 3T allow microscopic analysis of the bone structure at an isotropic spatial resolution of 200 µm in examination times of <10 min. Differences in the structure of the spongy bone between normal and markedly osteoporotic subjects are well depicted. The SNR at 3T was found up to 16 times higher than at 1.5T applying unchanged imaging parameters. Conclusion: The proposed high‐resolution MRI technique offers high potential in the diagnosis and follow‐up of diseases with impaired bone structure of hand and/or wrist in clinical applications.


1994 ◽  
Vol 4 (6) ◽  
Author(s):  
S. Majumdar ◽  
H.K. Genant ◽  
S. Grampp ◽  
M.D. Jergas ◽  
D.C. Newitt ◽  
...  

Author(s):  
HP Schlemmer ◽  
B Ludescher ◽  
P Martirosian ◽  
CD Claussen ◽  
F Schick

2015 ◽  
Vol 137 (1) ◽  
Author(s):  
Narges Kaynia ◽  
Elaine Soohoo ◽  
Tony M. Keaveny ◽  
Galateia J. Kazakia

This study investigated the effects of intraspecimen variations in tissue mineral density (TMD) on the apparent-level stiffness of human trabecular bone. High-resolution finite element (FE) models were created for each of 12 human trabecular bone specimens, using both microcomputed tomography (μCT) and “gold-standard” synchrotron radiation μCT (SRμCT) data. Our results confirm that incorporating TMD spatial variation reduces the calculated apparent stiffness compared to homogeneous TMD models. This effect exists for both μCT- and SRμCT-based FE models, but is exaggerated in μCT-based models. This study provides a direct comparison of μCT to SRμCT data and is thereby able to conclude that the influence of including TMD heterogeneity is overestimated in μCT-based models.


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