Rapid prototyping of plastic microfluidic devices in cyclic olefin copolymer (COC)

2005 ◽  
Author(s):  
Jin-Hwan Lee ◽  
Erik T. K. Peterson ◽  
Gabriel Dagani ◽  
Ian Papautsky
Keyword(s):  
Rapid Prototyping ◽  
Microfluidic Devices ◽  
Cyclic Olefin Copolymer ◽  
Cyclic Olefin

Rapid prototyping of cyclic olefin copolymer (COC) microfluidic devices

2017 ◽  
Vol 247 ◽  
pp. 940-949 ◽  
Author(s):  
S. Ali Aghvami ◽  
Achini Opathalage ◽  
Z.K. Zhang ◽  
Markus Ludwig ◽  
Michael Heymann ◽  
...  
Keyword(s):  
Rapid Prototyping ◽  
Microfluidic Devices ◽  
Cyclic Olefin Copolymer ◽  
Cyclic Olefin

Cyclic olefin copolymer as an X-ray compatible material for microfluidic devices

Lab on a Chip ◽  
2018 ◽  
Vol 18 (1) ◽  
pp. 171-178 ◽  
Author(s):  
Manuela Denz ◽  
Gerrit Brehm ◽  
Clément Y. J. Hémonnot ◽  
Heidi Spears ◽  
Andrew Wittmeier ◽  
...  
Keyword(s):  
Small Angle ◽  
Microfluidic Devices ◽  
Hot Embossing ◽  
Cyclic Olefin Copolymer ◽  
Cyclic Olefin ◽  
X Ray ◽  
X Ray Scattering ◽  
Ray Scattering

Fabrication of X-ray compatible microfluidic devices by hot embossing, and characterization for small angle X-ray scattering.

scholarly journals Cyclic Olefin Copolymer Microfluidic Devices for Forensic Applications

Biosensors ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 85 ◽  
Author(s):  
Brigitte Bruijns ◽  
Andrea Veciana ◽  
Roald Tiggelaar ◽  
Han Gardeniers
Keyword(s):  
Chemical Resistance ◽  
Multiple Displacement Amplification ◽  
Visible Region ◽  
Dna Amplification ◽  
Microfluidic Devices ◽  
Cyclic Olefin Copolymer ◽  
Color Test ◽  
Cyclic Olefin ◽  
On Chip ◽  
Amplification Reaction

Microfluidic devices offer important benefits for forensic applications, in particular for fast tests at a crime scene. A large portion of forensic applications require microfluidic chip material to show compatibility with biochemical reactions (such as amplification reactions), and to have high transparency in the visible region and high chemical resistance. Also, preferably, manufacturing should be simple. The characteristic properties of cyclic olefin copolymer (COC) fulfills these requirements and offers new opportunities for the development of new forensic tests. In this work, the versatility of COC as material for lab-on-a-chip (LOC) systems in forensic applications has been explored by realizing two proof-of-principle devices. Chemical resistance and optical transparency were investigated for the development of an on-chip presumptive color test to indicate the presence of an illicit substance through applying absorption spectroscopy. Furthermore, the compatibility of COC with a DNA amplification reaction was verified by performing an on-chip multiple displacement amplification (MDA) reaction.

scholarly journals Fast Fabrication Process of Microfluidic Devices Based on Cyclic Olefin Copolymer

2014 ◽  
Vol 29 (2) ◽  
pp. 93-99 ◽  
Author(s):  
Aymen Ben Azouz ◽  
Stephen Murphy ◽  
Shadi Karazi ◽  
Mercedes Vázquez ◽  
Dermot Brabazon
Keyword(s):  
Microfluidic Devices ◽  
Fabrication Process ◽  
Cyclic Olefin Copolymer ◽  
Cyclic Olefin

scholarly journals Rapid Manufacturing of Multilayered Microfluidic Devices for Organ on a Chip Applications

Sensors ◽  
2021 ◽  
Vol 21 (4) ◽  
pp. 1382
Author(s):  
Roberto Paoli ◽  
Davide Di Giuseppe ◽  
Maider Badiola-Mateos ◽  
Eugenio Martinelli ◽  
Maria Jose Lopez-Martinez ◽  
...  
Keyword(s):  
Rapid Prototyping ◽  
Soft Lithography ◽  
Microfluidic Devices ◽  
Device Fabrication ◽  
Rapid Manufacturing ◽  
Digital Manufacturing ◽  
Proof Of Concept ◽  
Cyclic Olefin ◽  
Protocol Optimization ◽  
Organ On A Chip

Microfabrication and Polydimethylsiloxane (PDMS) soft-lithography techniques became popular for microfluidic prototyping at the lab, but even after protocol optimization, fabrication is yet a long, laborious process and partly user-dependent. Furthermore, the time and money required for the master fabrication process, necessary at any design upgrade, is still elevated. Digital Manufacturing (DM) and Rapid-Prototyping (RP) for microfluidics applications arise as a solution to this and other limitations of photo and soft-lithography fabrication techniques. Particularly for this paper, we will focus on the use of subtractive DM techniques for Organ-on-a-Chip (OoC) applications. Main available thermoplastics for microfluidics are suggested as material choices for device fabrication. The aim of this review is to explore DM and RP technologies for fabrication of an OoC with an embedded membrane after the evaluation of the main limitations of PDMS soft-lithography strategy. Different material options are also reviewed, as well as various bonding strategies. Finally, a new functional OoC device is showed, defining protocols for its fabrication in Cyclic Olefin Polymer (COP) using two different RP technologies. Different cells are seeded in both sides of the membrane as a proof of concept to test the optical and fluidic properties of the device.

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