Photoacoustic tomography and molecular fluorescence imaging: dual modality imaging of small animal brains in vivo

2005 ◽  
Author(s):  
Xueyi Xie ◽  
Jung-Taek Oh ◽  
Meng-Lin Li ◽  
Geng Ku ◽  
Xueding Wang ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Small Animal ◽  
Photoacoustic Tomography ◽  
Dual Modality ◽  
Molecular Fluorescence ◽  
Dual Modality Imaging

scholarly journals Revealing the Distribution of Aggregation-Induced Emission Nanoparticles via Dual-Modality Imaging with Fluorescence and Mass Spectrometry

Research ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Liucheng Mao ◽  
Yuming Jiang ◽  
Hui Ouyang ◽  
Yulin Feng ◽  
Ruoxin Li ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Fluorescence Imaging ◽  
The Body ◽  
Ionization Mass ◽  
Label Free ◽  
Aggregation Induced Emission ◽  
Dual Modality ◽  
Imaging Strategy ◽  
Dual Modality Imaging

Aggregation-induced emission nanoparticles (AIE NPs) are widely used in the biomedical field. However, understanding the biological process of AIE NPs via fluorescence imaging is challenging because of the strong background and poor penetration depth. Herein, we present a novel dual-modality imaging strategy that combines fluorescence imaging and label-free laser desorption/ionization mass spectrometry imaging (LDI MSI) to map and quantify the biodistribution of AIE NPs (TPAFN-F127 NPs) by monitoring the intrinsic photoluminescence and mass spectrometry signal of the AIE molecule. We discovered that TPAFN-F127 NPs were predominantly distributed in the liver and spleen, and most gradually excreted from the body after 5 days. The accumulation and retention of TPAFN-F127 NPs in tumor sites were also confirmed in a tumor-bearing mouse model. As a proof of concept, the suborgan distribution of TPAFN-F127 NPs in the spleen was visualized by LDI MSI, and the results revealed that TPAFN-F127 NPs were mainly distributed in the red pulp of the spleen with extremely high concentrations within the marginal zone. The in vivo toxicity test demonstrated that TPAFN-F127 NPs are nontoxic for a long-term exposure. This dual-modality imaging strategy provides some insights into the fine distribution of AIE NPs and might also be extended to other polymeric NPs to evaluate their distribution and drug release behaviors in vivo.

scholarly journals Initial in vitro and in vivo assessment of Au@DTDTPA-RGD nanoparticles for Gd-MRI and 68Ga-PET dual modality imaging

2015 ◽  
Vol 2 (Suppl 1) ◽  
pp. A89 ◽  
Author(s):  
Charalmpos Tsoukalas ◽  
Gautier Laurent ◽  
Gloria Jiménez Sánchez ◽  
Theodoros Tsotakos ◽  
Rana Bazzi ◽  
...  
Keyword(s):  
Dual Modality ◽  
Dual Modality Imaging ◽  
In Vivo Assessment

In vivo NIRF and MR dual-modality imaging using glycol chitosan nanoparticles

2012 ◽  
Vol 163 (2) ◽  
pp. 249-255 ◽  
Author(s):  
Jaehong Key ◽  
Christy Cooper ◽  
Ah Young Kim ◽  
Deepika Dhawan ◽  
Deborah W. Knapp ◽  
...  
Keyword(s):  
Chitosan Nanoparticles ◽  
Glycol Chitosan ◽  
Dual Modality ◽  
Dual Modality Imaging

Coordination polymer hybridized Au nanocages: a nanoplatform for dual-modality imaging guided near-infrared driven photothermal therapy in vivo

2017 ◽  
Vol 5 (44) ◽  
pp. 8761-8769 ◽  
Author(s):  
Congyang Yan ◽  
Lili Cui ◽  
Qi Yang ◽  
Xiaobao Zhou ◽  
Lixing Pan ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Coordination Polymer ◽  
Mr Imaging ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Dual Modality ◽  
Dual Modality Imaging

Coordination polymer hybridized Au nanocages (AuNC@CPs) were prepared, which were used for near-infrared (NIR)-driven photothermal therapy (PTT) guided by photoacoustic (PA) and magnetic resonance (MR) imaging in vivo.

High speed in vivo endoscopic photoacoustic and ultrasound dual-modality imaging (Conference Presentation)

2019 ◽  
Author(s):  
Yan Li ◽  
Zhikai Zhou ◽  
Joseph Jing ◽  
Emon Heidari ◽  
Youmin He ◽  
...  
Keyword(s):  
High Speed ◽  
Dual Modality ◽  
Dual Modality Imaging
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