Deep penetrating photoacoustic tomography in biological tissues

Multispectral photoacoustic tomography for detection of small tumors inside biological tissues

Photons Plus Ultrasound: Imaging and Sensing 2018 ◽

10.1117/12.2293438 ◽

2018 ◽

Cited By ~ 1

Author(s):

Takeshi Hirasawa ◽

Shinpei Okawa ◽

Kazuhiro Tsujita ◽

Toshihiro Kushibiki ◽

Masanori Fujita ◽

...

Keyword(s):

Biological Tissues ◽

Photoacoustic Tomography

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Quantitative Photoacoustic Tomography in Biological Tissues Assisted with Intrinsic Acoustic Measurements

Biomedical Optics 2016 ◽

10.1364/ots.2016.otu2a.5 ◽

2016 ◽

Author(s):

Anabela Da Silva ◽

Charles Handschin ◽

Christophe Riedinger ◽

Serge Mensah ◽

Amélie Litman ◽

...

Keyword(s):

Biological Tissues ◽

Photoacoustic Tomography ◽

Acoustic Measurements

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Thermoacoustic and Photoacoustic Tomography of Thick Biological Tissues toward Breast Imaging

Technology in Cancer Research & Treatment ◽

10.1177/153303460500400509 ◽

2005 ◽

Vol 4 (5) ◽

pp. 559-565 ◽

Cited By ~ 92

Author(s):

Geng Ku ◽

Bruno D. Fornage ◽

Xing Jin ◽

Minghua Xu ◽

Kelly K. Hunt ◽

...

Keyword(s):

Breast Imaging ◽

Breast Tissue ◽

Biological Tissues ◽

Chicken Breast ◽

Photoacoustic Tomography ◽

Optical Contrast ◽

Good Spatial Resolution ◽

Malignant Breast Tissue ◽

Benign Breast Tissue ◽

Malignant Breast

Microwave-based thermoacoustic tomography (TAT) and laser-based photoacoustic tomography (PAT) in a circular scanning configuration were both developed to image deeply seated lesions and objects in biological tissues. Because malignant breast tissue absorbs microwaves more strongly than benign breast tissue, cancers were imaged with good spatial resolution and contrast by TAT in human breast mastectomy specimens. Based on the intrinsic optical contrast between blood and chicken breast muscle, an embedded blood object that was 5 cm deep in the tissue was also detected using PAT at a wavelength of 1064 nm.

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Recent Advances in Photoacoustic Tomography

BME Frontiers ◽

10.34133/2021/9823268 ◽

2021 ◽

Vol 2021 ◽

pp. 1-17

Author(s):

Lei Li ◽

Lihong V. Wang

Keyword(s):

Small Animal ◽

Biological Tissues ◽

Photoacoustic Tomography ◽

Label Free ◽

Preclinical Research ◽

Deep Tissue ◽

Technical Developments ◽

Tremendous Progress ◽

Technical Innovations ◽

Molecular Contrast

Photoacoustic tomography (PAT) that integrates the molecular contrast of optical imaging with the high spatial resolution of ultrasound imaging in deep tissue has widespread applications in basic biological science, preclinical research, and clinical trials. Recently, tremendous progress has been made in PAT regarding technical innovations, preclinical applications, and clinical translations. Here, we selectively review the recent progresses and advances in PAT, including the development of advanced PAT systems for small-animal and human imaging, newly engineered optical probes for molecular imaging, broad-spectrum PAT for label-free imaging of biological tissues, high-throughput snapshot photoacoustic topography, and integration of machine learning for image reconstruction and processing. We envision that PAT will have further technical developments and more impactful applications in biomedicine.

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Photoacoustic tomography imaging of biological tissues

10.1117/12.571936 ◽

2005 ◽

Author(s):

Yixiong Su ◽

Ruikang K. Wang ◽

Kexin Xu ◽

Fan Zhang ◽

Jianquan Yao

Keyword(s):

Biological Tissues ◽

Photoacoustic Tomography ◽

Tomography Imaging

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Nanoparticle Probes for Structural and Functional Photoacoustic Molecular Tomography

BioMed Research International ◽

10.1155/2015/757101 ◽

2015 ◽

Vol 2015 ◽

pp. 1-11 ◽

Cited By ~ 12

Author(s):

Haobin Chen ◽

Zhen Yuan ◽

Changfeng Wu

Keyword(s):

Molecular Imaging ◽

Biomedical Applications ◽

High Sensitivity ◽

Biological Tissues ◽

Structure And Function ◽

Photoacoustic Tomography ◽

Optical Contrast ◽

Photoacoustic Effect ◽

Nanoparticle Probes ◽

And Function

Nowadays, nanoparticle probes have received extensive attention largely due to its potential biomedical applications in structural, functional, and molecular imaging. In addition, photoacoustic tomography (PAT), a method based on the photoacoustic effect, is widely recognized as a robust modality to evaluate the structure and function of biological tissues with high optical contrast and high acoustic resolution. The combination of PAT with nanoparticle probes holds promises for detecting and imaging diseased tissues or monitoring their treatments with high sensitivity. This review will introduce the recent advances in the emerging field of nanoparticle probes and their preclinical applications in PAT, as well as relevant perspectives on future development.

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