A theoretical model on optical clearing of biological tissue with chemical active agents

2004 ◽  
Author(s):  
Fujun Zhou ◽  
Yonghong He ◽  
Ruikang K. Wang
Keyword(s):  
Theoretical Model ◽  
Biological Tissue ◽  
Optical Clearing

Heating and cutting of biological tissue by highly absorbed laser beams: theoretical model and experiments

1990 ◽  
Author(s):  
A. M. Sagi ◽  
Avraham Shitzer ◽  
Ariella Avidor ◽  
Solange Akselrod ◽  
Abraham Katzir
Keyword(s):  
Theoretical Model ◽  
Biological Tissue ◽  
Laser Beams

Measurement of the Laser Exposure Levels for Burn Threshold in Biological Tissue

1984 ◽  
Vol 106 (3) ◽  
pp. 283-284 ◽  
Author(s):  
G. Laufer ◽  
H. Z. Joachims ◽  
I. Eliachar ◽  
D. Mordechovitz
Keyword(s):  
Theoretical Model ◽  
Soft Tissue ◽  
Energy Density ◽  
Biological Tissue ◽  
Pain Threshold ◽  
Laser Energy ◽  
Laser Energy Density ◽  
Laser Exposure ◽  
Safety Standards ◽  
Exposure Levels

Experiments for the evaluation of the laser energy density required to induce burn threshold in biological tissue are presented. The results are compared with a theoretical model. The values obtained for soft tissue are higher than the pain threshold and the safety standards for the maximum permissible exposure. This is due to the different nature of injury associated with the surgical process.

Mechanical Compression for Dehydration and Optical Clearing of Skin

2008 ◽  
Author(s):  
Chris W. Drew ◽  
Christopher G. Rylander
Keyword(s):  
Refractive Index ◽  
Light Scattering ◽  
Penetration Depth ◽  
Biological Tissue ◽  
Structural Modification ◽  
Incident Light ◽  
Optical Clearing ◽  
Treatment Techniques ◽  
Index Distribution ◽  
Tissue Optical Clearing

The highly disordered refractive index distribution in biological tissue causes multiple-scattering of incident light and inhibits optical penetration depth. “Tissue optical clearing” increases penetration depth of near-collimated light in biological tissue, potentially resulting in improved optical analysis and treatment techniques. Numerous methods of tissue optical clearing have been hypothesized using hyperosmostic agents [1]. These methods propose reduction in light scattering by means of dehydration of tissue constituents, replacement of interstitial or intracellular water with higher refractive agents, or structural modification or dissociation of collagen fibers [2,3]. It has been suggested that dehydration of tissue constituents alone can reduce light scattering by expulsing water between collagen fibrils, increasing protein and sugar concentrations, and decreasing refractive index mismatch [4].

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