Lung imaging of laboratory rodents in vivo

2004 ◽  
Author(s):  
Dianna D. Cody ◽  
Dawn Cavanaugh ◽  
Roger E. Price ◽  
Belinda Rivera ◽  
Gregory Gladish ◽  
...  
Keyword(s):  
Lung Imaging ◽  
Laboratory Rodents

scholarly journals Impact of Hydrogel Nanoparticle Size and Functionalization on In Vivo Behavior for Lung Imaging and Therapeutics

2009 ◽  
Vol 6 (6) ◽  
pp. 1891-1902 ◽  
Author(s):  
Yongjian Liu ◽  
Aida Ibricevic ◽  
Joel A. Cohen ◽  
Jessica L. Cohen ◽  
Sean P. Gunsten ◽  
...  
Keyword(s):  
Lung Imaging ◽  
Nanoparticle Size

In vivo lung imaging in pulmonary disease model

2015 ◽  
Author(s):  
Inwon Park ◽  
Kibaek Choe ◽  
Yoonha Hwang ◽  
Howon Seo ◽  
Eunjoo Song ◽  
...  
Keyword(s):  
Pulmonary Disease ◽  
Disease Model ◽  
Lung Imaging

scholarly journals Fluorine-19 Mri Contrast Agents for Cell Tracking and Lung Imaging

2015 ◽  
Vol 8s1 ◽  
pp. MRI.S23559 ◽  
Author(s):  
Matthew S. Fox ◽  
Jeffrey M. Gaudet ◽  
Paula J. Foster
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Cell Tracking ◽  
Cellular Therapy ◽  
Medical Intervention ◽  
Mri Contrast Agents ◽  
Lung Imaging ◽  
Resonance Imaging

Fluorine-19 (19F)-based contrast agents for magnetic resonance imaging stand to revolutionize imaging-based research and clinical trials in several fields of medical intervention. First, their use in characterizing in vivo cell behavior may help bring cellular therapy closer to clinical acceptance. Second, their use in lung imaging provides novel noninvasive interrogation of the ventilated airspaces without the need for complicated, hard-to-distribute hardware. This article reviews the current state of 19F-based cell tracking and lung imaging using magnetic resonance imaging and describes the link between the methods across these fields and how they may mutually benefit from solutions to mutual problems encountered when imaging 19F-containing compounds, as well as hardware and software advancements.

scholarly journals Consecutive CT in vivo lung imaging as quantitative parameter of influenza vaccine efficacy in the ferret model

Vaccine ◽  
2012 ◽  
Vol 30 (51) ◽  
pp. 7391-7394 ◽  
Author(s):  
Edwin J.B. Veldhuis Kroeze ◽  
Koert J. Stittelaar ◽  
Vera J. Teeuwsen ◽  
Marcel L. Dijkshoorn ◽  
Geert van Amerongen ◽  
...  
Keyword(s):  
Influenza Vaccine ◽  
Vaccine Efficacy ◽  
Lung Imaging ◽  
Quantitative Parameter

Endocrine Toxicity of Drinking Water Disinfectants. I. In Vivo Dehalogenation and Clearance of Iodinated Nutrients

1991 ◽  
Vol 10 (5) ◽  
pp. 525-532 ◽  
Author(s):  
J. P. Bercz
Keyword(s):  
Drinking Water ◽  
Logical Consequence ◽  
Covalent Binding ◽  
Iodine Content ◽  
Female Rats ◽  
Oral Exposure ◽  
Laboratory Rodents ◽  
Thyroid Uptake

Ingestion of aqueous chlorine-based disinfectants has been shown earlier to cause decreased serum thyroxine levels and increased 131-I thyroid uptake in nonhuman primates. Disinfectants also were shown to immobilize iodine on gastric mucosa and cause covalent binding of dietary iodide to gastrointestinal contents in laboratory rodents. It has been demonstrated that nutrients in the presence of chlorine oxides, under conditions simulating the alimentary tract, effectively organify I- in vitro. A logical consequence of these is that traces of iodinated organics are absorbed after ingestion of drinking water disinfectants. Since over 100 million consumers receive a daily dose of about 0.4 mM of free chlorine, the pharmacotoxicology of such modified nutrient molecules is of public health interest. Therefore, we examined the in vivo deiodination of randomly in vitro iodinated organic mixtures prepared from different nutrients. Using adult female rats, we determined the 24-hour thyroid uptake of 125-I liberated from nutrients administered by gavage, relative to simultaneously ip-injected I131-. Also, 24-hour fecal and urinary clearances of the iodinated organics as well as tissue distributions were determined. The results showed that although various iodinated nutrient classes widely differed in their in vivo fate, most were dehalogenated effectively. Thus, their iodine content was returned as inorganic I- for thyroid uptake. It was also shown that tissue (blood, liver, intestinal, adipose, and muscle) distribution of the two isotopes did not differ significantly, suggesting that at 24 hours, the originally organic iodine existed in the tissues as inorganic I-. It is likely that oral exposure to chlorine-based disinfectants did not disturb the bioavailability of I-, and any thyroid effects caused were due to mechanisms other than I- deficiency.

An optimized two-photon method for in vivo lung imaging reveals intimate cell collaborations during infection

2013 ◽  
Author(s):  
Daniel Fiole ◽  
Pierre Deman ◽  
Yannick Trescos ◽  
Julien Douady ◽  
Jean-Nicolas Tournier
Keyword(s):  
Lung Imaging ◽  
Two Photon

Influence of dietary protein on selected measures of humoral and cellular immunity in the cotton rat Sigmodon hispidus

1993 ◽  
Vol 71 (3) ◽  
pp. 579-586 ◽  
Author(s):  
M. R. Vestey ◽  
S. T. McMurry ◽  
R. L. Lochmiller
Keyword(s):  
Dietary Protein ◽  
Inbred Strains ◽  
Lymphoid Organ ◽  
Delayed Type Hypersensitivity ◽  
Cell Mediated Immunity ◽  
Humoral And Cellular Immunity ◽  
Laboratory Rodents ◽  
Cotton Rats

Small-mammal populations are subject to unpredictable and often dramatic fluctuations in numbers, but the mechanisms underlying this phenomenon are largely unclear. It has been suggested that protein is an important nutritional factor limiting survival, so we explored the effect of protein intake on the immunocompetence of cotton rats (Sigmodon hipsidus). In vivo and in vitro measures of both humoral and cell-mediated immunity were examined in a series of four protein-feeding trials (with weanlings, juveniles, subadults, and adults), using animals randomly assigned to an isocaloric diet containing either 4 or 16% crude protein. The response of lymphoid organ mass and cellularity to low dietary protein was variable, the spleen being more sensitive to dietary protein than the thymus. The ability of splenic lymphocytes to respond to in vitro stimulation with mitogens was unaffected by dietary protein, while the capacity of weanling and subadult cotton rats fed 4% protein to mount a delayed-type hypersensitivity response was enhanced. Nonspecific immunity (complement activity) was reduced in juveniles fed 4% protein. Dietary protein did not influence the ability of subadults or adults to generate a specific antibody response. These data suggest that cotton rats are less sensitive to dietary protein level than many inbred strains of laboratory rodents, younger animals may be at greater risk, and nutritional history may influence the response of a population to a reduction in available dietary protein.

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