HIGH SPEED, HIGH RESOLUTION in vivo DYNAMIC LUNG IMAGING USING A LABORATORY X-RAY SOURCE TO MEASURE REGIONAL LUNG FUNCTION AND PULMONARY VASCULATURE

Respirology ◽  
2017 ◽  
Vol 22 ◽  
pp. 26-26
Keyword(s):  
High Resolution ◽  
Lung Function ◽  
High Speed ◽  
Lung Imaging ◽  
Pulmonary Vasculature ◽  
X Ray ◽  
Regional Lung Function ◽  
Regional Lung

scholarly journals Real-time in vivo imaging of regional lung function in a mouse model of cystic fibrosis on a laboratory X-ray source

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Rhiannon P. Murrie ◽  
Freda Werdiger ◽  
Martin Donnelley ◽  
Yu-wei Lin ◽  
Richard P. Carnibella ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Mouse Model ◽  
Real Time ◽  
In Vivo Imaging ◽  
X Ray ◽  
Regional Lung Function ◽  
Regional Lung

scholarly journals FIRST-IN-HUMAN VALIDATION OF X-RAY VELOCIMETRY DEMONSTRATES SUPERIOR SENSITIVITY OVER SPIROMETRY AND CT FOR QUANTIFICATION OF REGIONAL LUNG FUNCTION

CHEST Journal ◽  
2020 ◽  
Vol 158 (4) ◽  
pp. A1393-A1394
Author(s):  
Jonathan Dusting ◽  
Olivia Stephens ◽  
David Wenger ◽  
Chandni Doshi ◽  
John DeMarco ◽  
...  
Keyword(s):  
Lung Function ◽  
X Ray ◽  
Regional Lung Function ◽  
Regional Lung ◽  
Human Validation

scholarly journals NOVEL X-RAY VELOCIMETRY-BASED QUANTITATIVE REGIONAL LUNG FUNCTION ANALYSIS TO ASSESS RISK OF RADIATION-INDUCED PNEUMONITIS AND PULMONARY FIBROSIS

CHEST Journal ◽  
2019 ◽  
Vol 156 (4) ◽  
pp. A2264-A2265
Author(s):  
Andreas Fouras ◽  
Stephen Shiao ◽  
David Wenger ◽  
Alex Winnett ◽  
Chandni Doshi ◽  
...  
Keyword(s):  
Lung Function ◽  
Pulmonary Fibrosis ◽  
Function Analysis ◽  
X Ray ◽  
Regional Lung Function ◽  
Regional Lung ◽  
Radiation Induced

Comparison of indices of regional lung function from 4-D X-ray CT: Jacobian vs. strain of deformation

2013 ◽  
Author(s):  
Mohammadreza Negahdar ◽  
Neal Dunlap ◽  
Albert Zacarias ◽  
A Cahid Civelek ◽  
Shiao Y Woo ◽  
...  
Keyword(s):  
Lung Function ◽  
X Ray ◽  
Regional Lung Function ◽  
Regional Lung

scholarly journals Utilization of 19F MRI for Identification of Iraq-Afghanistan War Lung Injury

2020 ◽  
Vol 185 (Supplement_1) ◽  
pp. 50-56
Author(s):  
Joseph G Mammarappallil ◽  
Scott Shofer ◽  
Martha S Carraway ◽  
Jesse Tucker ◽  
Samantha Womack ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Pilot Study ◽  
High Resolution ◽  
Lung Function ◽  
Lung Injury ◽  
Normal Lung ◽  
Chest Computed Tomography ◽  
Regional Lung Function ◽  
19F Mri ◽  
Regional Lung

ABSTRACT Introduction There is mounting evidence of respiratory problems related to military service in the Middle East in the past two decades due to environmental exposures during deployment (eg, sand storms and burn pits). This pilot study tests the hypothesis that regional lung function in subjects with prior deployment in Iraq and/or Afghanistan with suspected War Lung Injury (WLI) would be worse than subjects with normal lung function. Materials and Methods Five subjects meeting the inclusion and exclusion criteria were recruited for this pilot study. All subjects underwent spirometry, high-resolution chest computed tomography imaging, and 19F MRI. Results While the WLI subjects had normal pulmonary function tests and normal high-resolution chest computed tomography evaluations, their regional lung function from 19F MRI was abnormal with compartments with poor function showing slower filling time constants for ventilation. The scans of suspected WLI subjects show higher fractional lung volume with slow filling compartments similar to patients with chronic obstructive pulmonary disease in contrast to normal subjects. Conclusions This is consistent with our premise that WLI results in abnormal lung function and reflects small airways dysfunction and suggests that we may be able to provide a more sensitive tool for evaluation of WLI suspected cases.

scholarly journals High-speed high-resolution laser diode-based photoacoustic microscopy for in vivo microvasculature imaging

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Xiufeng Li ◽  
Victor T C Tsang ◽  
Lei Kang ◽  
Yan Zhang ◽  
Terence T W Wong
Keyword(s):  
High Resolution ◽  
High Speed ◽  
High Performance ◽  
Continuous Wave ◽  
Signal To Noise Ratio ◽  
Cost Effective ◽  
High Signal ◽  
Photoacoustic Microscopy ◽  
Mouse Ear

AbstractLaser diodes (LDs) have been considered as cost-effective and compact excitation sources to overcome the requirement of costly and bulky pulsed laser sources that are commonly used in photoacoustic microscopy (PAM). However, the spatial resolution and/or imaging speed of previously reported LD-based PAM systems have not been optimized simultaneously. In this paper, we developed a high-speed and high-resolution LD-based PAM system using a continuous wave LD, operating at a pulsed mode, with a repetition rate of 30 kHz, as an excitation source. A hybrid scanning mechanism that synchronizes a one-dimensional galvanometer mirror and a two-dimensional motorized stage is applied to achieve a fast imaging capability without signal averaging due to the high signal-to-noise ratio. By optimizing the optical system, a high lateral resolution of 4.8 μm has been achieved. In vivo microvasculature imaging of a mouse ear has been demonstrated to show the high performance of our LD-based PAM system.

scholarly journals Use of Radioactive Xenon for Studies of Regional Lung Function

BMJ ◽  
1962 ◽  
Vol 2 (5311) ◽  
pp. 1006-1016 ◽  
Author(s):  
C. T. Dollery ◽  
P. Hugh-Jones ◽  
C. M. E. Matthews
Keyword(s):  
Lung Function ◽  
Regional Lung Function ◽  
Regional Lung ◽  
Radioactive Xenon
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