Laser driven high energy ion generation for a compact cancer therapy accelerator

2003 ◽  
Author(s):  
Koji Matsukado ◽  
Hiroyuki Daido ◽  
Zhong Li ◽  
Atsushi Fukumi ◽  
Yukio Hayashi ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
High Energy ◽  
Ion Generation

Medical Cyclotrons

2009 ◽  
Vol 02 (01) ◽  
pp. 133-156 ◽  
Author(s):  
D. L. Friesel ◽  
T. A. Antaya
Keyword(s):  
Cancer Therapy ◽  
Scientific Research ◽  
High Energy ◽  
Industrial Applications ◽  
Medical Applications ◽  
Particle Accelerators ◽  
Radioisotope Production ◽  
Practical Applications ◽  
Medical Radioisotope ◽  
High Energy Particles

Particle accelerators were initially developed to address specific scientific research goals, yet they were used for practical applications, particularly medical applications, within a few years of their invention. The cyclotron's potential for producing beams for cancer therapy and medical radioisotope production was realized with the early Lawrence cyclotrons and has continued with their more technically advanced successors — synchrocyclotrons, sector-focused cyclotrons and superconducting cyclotrons. While a variety of other accelerator technologies were developed to achieve today's high energy particles, this article will chronicle the development of one type of accelerator — the cyclotron, and its medical applications. These medical and industrial applications eventually led to the commercial manufacture of both small and large cyclotrons and facilities specifically designed for applications other than scientific research.

scholarly journals Photodynamic Therapy Excited by Cerenkov Radiation from Cesium-137 Irradiator: In Vitro Studies

2020 ◽  
pp. 1-5
Author(s):  
Changqing Li ◽  
Yiping Guo ◽  
Shi Sheng ◽  
Michael C. Lun ◽  
Shih-Ming Tsai ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
High Energy ◽  
Cerenkov Radiation ◽  
Additional Energy ◽  
Lung Carcinoma Cell Line ◽  
Cesium 137 ◽  
Human Lung Carcinoma ◽  
Human Lung Carcinoma Cell

Photodynamic therapy (PDT) is a non-invasive cancer therapy method that has been clinically approved for many years. Due to strong optical scattering and absorption of tissues, optical photons can only penetrate tissues several millimetres, which limits the applications of PDT to superficial lesions. To overcome the limitation of penetration depth, here we applied Cerenkov radiation, as generated by the high-energy -rays from radionuclide Cesium-137, to directly activate the porphyrin-based photosensitizer MPPa (Pyropheophorbide-a methyl ester) without any additional energy mediators. Experiments were conducted with A549 human lung carcinoma cell line. Moreover, to reduce the effects of possible plastic scintillation on PDT, we used black cell culture plates in these studies. We have also shown that the effects of the scintillations on PDT could be minimized. In our studies, we have excluded the effects of radiotherapy and drug toxicity. Our results indicated that the Cerenkov radiation generated from high energy -rays could be used to activate the photosensitizer MPPa in PDT, which could potentially overcome the penetration limitations of optical photon-based PDT, making the PDT a feasible and complementary cancer therapy for deep lesions.

High energy negative ion generation by Coulomb implosion mechanism

2009 ◽  
Vol 16 (11) ◽  
pp. 113106 ◽  
Author(s):  
T. Nakamura ◽  
Y. Fukuda ◽  
A. Yogo ◽  
M. Tampo ◽  
M. Kando ◽  
...  
Keyword(s):  
High Energy ◽  
Negative Ion ◽  
Ion Generation

Pulsed high energy ultrasound-a potential approach to cancer therapy?

2002 ◽  
Author(s):  
E.W. Hahn ◽  
P. Peschke ◽  
E. Debus ◽  
W. Folberth ◽  
G. van Kaick
Keyword(s):  
Cancer Therapy ◽  
High Energy ◽  
Potential Approach

Design criteria for a high energy Compton Camera and possible application to targeted cancer therapy

2015 ◽  
Vol 10 (07) ◽  
pp. C07018-C07018 ◽  
Author(s):  
T. Conka Nurdan ◽  
K. Nurdan ◽  
A.B. Brill ◽  
A.H. Walenta
Keyword(s):  
Cancer Therapy ◽  
High Energy ◽  
Design Criteria ◽  
Targeted Cancer Therapy ◽  
Compton Camera
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