Photosensitive liposomes as potential drug delivery vehicles for photodynamic therapy

Author(s):  
Christopher G. Morgan ◽  
A. C. Mitchell ◽  
R. K. Chowdhary
2012 ◽  
Vol 1 (2) ◽  
pp. 111-146 ◽  
Author(s):  
Ying-Ying Huang ◽  
Sulbha K. Sharma ◽  
Tianhong Dai ◽  
Hoon Chung ◽  
Anastasia Yaroslavsky ◽  
...  

AbstractPhotodynamic therapy (PDT) uses the combination of nontoxic dyes and harmless visible light to produce reactive oxygen species that can kill cancer cells and infectious microorganisms. Due to the tendency of most photosensitizers (PS) to be poorly soluble and to form nonphotoactive aggregates, drug-delivery vehicles have become of high importance. The nanotechnology revolution has provided many examples of nanoscale drug-delivery platforms that have been applied to PDT. These include liposomes, lipoplexes, nanoemulsions, micelles, polymer nanoparticles (degradable and nondegradable), and silica nanoparticles. In some cases (fullerenes and quantum dots), the actual nanoparticle itself is the PS. Targeting ligands such as antibodies and peptides can be used to increase specificity. Gold and silver nanoparticles can provide plasmonic enhancement of PDT. Two-photon excitation or optical upconversion can be used instead of one-photon excitation to increase tissue penetration at longer wavelengths. Finally, after sections on in vivo studies and nanotoxicology, we attempt to answer the title question, “can nanotechnology potentiate PDT?”


2010 ◽  
Vol 19 (7) ◽  
pp. 528-539 ◽  
Author(s):  
Kumkum Ganguly ◽  
Ruilian Wu ◽  
Morgane Ollivault-Shiflett ◽  
Peter M. Goodwin ◽  
Louis A. Silks ◽  
...  

2007 ◽  
Vol 3 (6) ◽  
pp. 605-611 ◽  
Author(s):  
Sandeep Verma ◽  
K. Joshi ◽  
Surajit Ghosh

2015 ◽  
Vol 3 (2) ◽  
pp. 323-335 ◽  
Author(s):  
Sema Sevimli ◽  
Sharon Sagnella ◽  
Alexander Macmillan ◽  
Renee Whan ◽  
Maria Kavallaris ◽  
...  

Previously synthesized poly(methacrylic acid-co-cholesteryl methacrylate) P(MAA-co-CMA) copolymers were examined as potential drug delivery vehicles.


RSC Advances ◽  
2015 ◽  
Vol 5 (68) ◽  
pp. 55536-55543 ◽  
Author(s):  
Malinda Salim ◽  
Osama K. Abou-Zied ◽  
H. Udani Kulathunga ◽  
Asweni Baskaran ◽  
Umah R. Kuppusamy ◽  
...  

This work evaluates and compares alkyl mono- and di-glucoside sugar vesicles as potential delivery vehicles for small hydrophilic compounds.


2020 ◽  
Vol 8 (34) ◽  
pp. 7696-7712
Author(s):  
Alessandro Torchio ◽  
Monica Boffito ◽  
Andrea Gallina ◽  
Mario Lavella ◽  
Claudio Cassino ◽  
...  

A library of poly(ether urethane)-based supramolecular hydrogels was designed, showing quick gelation, no phase separation, remarkable mechanical and self-healing properties.


Author(s):  
Sushama Talegaonkar ◽  
Namrata Gautam ◽  
Venu Varshney ◽  
Sandeep Kumar Sharma ◽  
Arundhati Bhattacharyya

2018 ◽  
Vol 10 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Kagiso Laka ◽  
Peter Kganyago ◽  
Nomvano Mketo ◽  
Zikhona Nobuntu Tetana ◽  
Nomso Charmaine Hintsho-Mbita ◽  
...  

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