Alkyl mono- and di-glucoside sugar vesicles as potential drug delivery vehicles: detecting drug release using fluorescence

RSC Advances ◽  
2015 ◽  
Vol 5 (68) ◽  
pp. 55536-55543 ◽  
Author(s):  
Malinda Salim ◽  
Osama K. Abou-Zied ◽  
H. Udani Kulathunga ◽  
Asweni Baskaran ◽  
Umah R. Kuppusamy ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Potential Drug ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Hydrophilic Compounds

This work evaluates and compares alkyl mono- and di-glucoside sugar vesicles as potential delivery vehicles for small hydrophilic compounds.

scholarly journals BI-GELS: A NOVEL MATERIAL FOR TRANSDERMAL DRUG DELIVERY

2021 ◽  
pp. 1-5
Author(s):  
SARIPILLI RAJESWARI ◽  
RAJESWARI PULLABHATLA ◽  
CHUKKA YERNI SATYAVATHI
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Transdermal Drug Delivery ◽  
Drug Release Rate ◽  
Drug Delivery Vehicles ◽  
Novel Material ◽  
Delivery Vehicles ◽  
Semi Solid ◽  
Transdermal Route ◽  
Application Property

Bi-gels semi solid formulation is combination of organogel and hydrogel with better application property such as pharmaceutical and cosmetics. The main objective of this review is specially focuses on application of bi-gels as drug delivery vehicles by transdermal route. It contains two different phases which are polar and nonpolar due to which, it possess some significant features such as ability to deliver the hydrophilic and hydrophobic drugs which also have improved permeability of drugs, better spreading ability, and water wash ability. Hence, bigels have both organogels and hydrogels they can enhanced hydration of stratum corneum and also had an ability to manipulate the drug release rate from the dosage from.

scholarly journals Magnetically responsive layer-by-layer microcapsules can be retained in cells and under flow conditions to promote local drug release without triggering ROS production

Nanoscale ◽  
2020 ◽  
Vol 12 (14) ◽  
pp. 7735-7748 ◽  
Author(s):  
Jordan E. Read ◽  
Dong Luo ◽  
Tina T. Chowdhury ◽  
Rod J. Flower ◽  
Robin N. Poston ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Migration ◽  
Drug Release ◽  
Layer By Layer ◽  
Ros Production ◽  
Flow Conditions ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Migration Assays ◽  
In Cells

Magnetically responsive LbL microcapsules are biologically inert, magnetically retained in flow and cell migration assays so are retainable drug delivery vehicles.

scholarly journals Design, synthesis, and a novel application of quorum-sensing agonists as potential drug-delivery vehicles

2010 ◽  
Vol 19 (7) ◽  
pp. 528-539 ◽  
Author(s):  
Kumkum Ganguly ◽  
Ruilian Wu ◽  
Morgane Ollivault-Shiflett ◽  
Peter M. Goodwin ◽  
Louis A. Silks ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quorum Sensing ◽  
Potential Drug ◽  
Design Synthesis ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

Physical stimuli-responsive liposomes and polymersomes as drug delivery vehicles based on phase transitions in the membrane

Nanoscale ◽  
2018 ◽  
Vol 10 (15) ◽  
pp. 6781-6800 ◽  
Author(s):  
Yangwei Deng ◽  
Jun Ling ◽  
Min-Hui Li
Keyword(s):  
Drug Delivery ◽  
Phase Transitions ◽  
Drug Release ◽  
Liquid Crystalline ◽  
Stimuli Responsive ◽  
Physical Stimulation ◽  
Drug Delivery Vehicles ◽  
Liquid Crystalline Phases ◽  
Physical Stimuli ◽  
Delivery Vehicles

Crystalline and liquid crystalline phases in the membrane lead to intriguing morphologies of vesicles for drug release upon physical stimulation.

Fe3O4@carbon@zeolitic imidazolate framework-8 nanoparticles as multifunctional pH-responsive drug delivery vehicles for tumor therapy in vivo

2015 ◽  
Vol 3 (46) ◽  
pp. 9033-9042 ◽  
Author(s):  
Mengni He ◽  
Jiajia Zhou ◽  
Jian Chen ◽  
Fangcai Zheng ◽  
Dongdong Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Tumor Therapy ◽  
Controlled Drug Release ◽  
Ph Responsive ◽  
Zeolitic Imidazolate Framework ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

Controlled drug release is a promising approach for cancer therapy due to its merits of reduced systemic toxicity and enhanced antitumor efficacy.

Peptide-Based Soft Materials as Potential Drug Delivery Vehicles

2007 ◽  
Vol 3 (6) ◽  
pp. 605-611 ◽  
Author(s):  
Sandeep Verma ◽  
K. Joshi ◽  
Surajit Ghosh
Keyword(s):  
Drug Delivery ◽  
Soft Materials ◽  
Potential Drug ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

scholarly journals Doxorubicin–Gelatin/Fe3O4–Alginate Dual-Layer Magnetic Nanoparticles as Targeted Anticancer Drug Delivery Vehicles

Polymers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 1747
Author(s):  
Chiung-Hua Huang ◽  
Ting-Ju Chuang ◽  
Cherng-Jyh Ke ◽  
Chun-Hsu Yao
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Magnetic Layer ◽  
Drug Delivery Vehicles ◽  
Anticancer Drug Delivery ◽  
Delivery Vehicles ◽  
Mcf 7

In this study, magnetic nanoparticles composed of a core (doxorubicin–gelatin) and a shell layer (Fe3O4–alginate) were developed to function as targeted anticancer drug delivery vehicles. The anticancer drug doxorubicin (DOX) was selected as a model drug and embedded in the inner gelatin core to obtain high encapsulation efficiency. The advantage of the outer magnetic layer is that it targets the drug to the tumor tissue and provides controlled drug release. The physicochemical properties of doxorubicin–gelatin/Fe3O4–alginate nanoparticles (DG/FA NPs) were characterized using scanning electron microscopy, Fourier transform infrared spectroscopy (FTIR), and X-ray diffraction. The mean diameter of DG/FA NPs, which was determined using a zeta potential analyzer, was 401.8 ± 3.6 nm. The encapsulation rate was 64.6 ± 11.8%. In vitro drug release and accumulation were also studied. It was found that the release of DOX accelerated in an acidic condition. With the manipulation of an external magnetic field, DG/FA NPs efficiently targeted Michigan Cancer Foundation-7 (MCF-7) breast cancer cells and showed in the nucleus after 6 h of incubation. After 12 h of incubation, the relative fluorescence intensity reached 98.4%, and the cell viability of MCF-7 cells decreased to 52.3 ± 4.64%. Dual-layer DG/FA NPs could efficiently encapsulate and deliver DOX into MCF-7 cells to cause the death of cancer cells. The results show that DG/FA NPs have the potential for use in targeted drug delivery and cancer therapy.

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