Real-time SHG imaging technique based on a 2-GHz repetition rate femtosecond Ti:sapphire laser

2003 ◽  
Author(s):  
Shi-Wei Chu ◽  
Tzu-Ming Liu ◽  
I-Hsiu Chen ◽  
Chi-Kuang Sun ◽  
Cheng-Yung Lin ◽  
...  
Keyword(s):  
Real Time ◽  
Repetition Rate ◽  
Imaging Technique ◽  
Ti:Sapphire Laser

scholarly journals Real-time second-harmonic-generation microscopy based on a 2-GHz repetition rate Ti:sapphire laser

2003 ◽  
Vol 11 (8) ◽  
pp. 933 ◽  
Author(s):  
Shi-Wei Chu ◽  
Tzu-Ming Liu ◽  
Chi-Kuang Sun ◽  
Cheng-Yung Lin ◽  
Huai-Jen Tsai
Keyword(s):  
Second Harmonic Generation ◽  
Real Time ◽  
Harmonic Generation ◽  
Repetition Rate ◽  
Second Harmonic ◽  
Ti:Sapphire Laser ◽  
Second Harmonic Generation Microscopy

FastCam: Real-Time Implementation of the Lucky Imaging Technique using FPGA

2008 ◽  
Author(s):  
J. Piqueras ◽  
L. Rodriguez-Ramos ◽  
Y. Martin ◽  
J. J. Martinez-Alvarez
Keyword(s):  
Real Time ◽  
Imaging Technique

scholarly journals Strong second harmonic generation in SiC, ZnO, GaN two-dimensional hexagonal crystals from first-principles many-body calculations

2015 ◽  
Vol 17 (14) ◽  
pp. 9533-9540 ◽  
Author(s):  
C. Attaccalite ◽  
A. Nguer ◽  
E. Cannuccia ◽  
M. Grüning
Keyword(s):  
Second Harmonic Generation ◽  
Real Time ◽  
Harmonic Generation ◽  
First Principles ◽  
Function Theory ◽  
Second Harmonic ◽  
Two Dimensional ◽  
Many Body ◽  
Ti:Sapphire Laser ◽  
Hexagonal Crystals

By using a real-time approach based on Green's function theory we predict a strong second-harmonic generation (SHG) for frequencies at which Ti:sapphire laser operates and for which the materials are transparent.

ITVT-10. Using functional Ultrasound (fUS) for real-time, depth-resolved functional and vascular delineation of brain tumors with micrometer-millisecond precision

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi230-vi230
Author(s):  
Sadaf Soloukey ◽  
Luuk Verhoef ◽  
Frits Mastik ◽  
Bastian Generowicz ◽  
Eelke Bos ◽  
...  
Keyword(s):  
High Resolution ◽  
Real Time ◽  
Cerebral Blood Volume ◽  
Imaging Technique ◽  
Power Doppler ◽  
Ease Of Use ◽  
Frame Rate ◽  
Neurosurgical Procedures ◽  
Vascular Morphology

Abstract BACKGROUND Neurosurgical practice still relies heavily on pre-operatively acquired images to guide tumor resections, a practice which comes with inherent pitfalls such as registration inaccuracy due to brain shift, and lack of real-time functional or morphological feedback. Here we describe functional Ultrasound (fUS) as a new high-resolution, depth-resolved, MRI/CT-registered imaging technique able to detect functional regions and vascular morphology during awake and anesthesized tumor resections. MATERIALS AND METHODS fUS relies on high-frame-rate (HFR) ultrasound, making the technique sensitive to very small motions caused by vascular dynamics (µDoppler) and allowing measurements of changes in cerebral blood volume (CBV) with micrometer-millisecond precision. This opens up the possibility to 1) detect functional response, as CBV-changes reflect changes in metabolism of activated neurons through neurovascular coupling, and 2) visualize in-vivo vascular morphology of pathological and healthy tissue with high resolution at unprecedented depths. During a range of anesthetized and awake neurosurgical procedures we acquired vascular and functional images of brain and spinal cord using conventional ultrasound probes connected to a research acquisition system. Building on Brainlab’s Intra-Operative Navigation modules, we co-registered our intra-operative Power Doppler Images (PDIs) to patient-registered MRI/CT-data in real-time. RESULTS During meningioma and glioma resections, our co-registered PDIs revealed fUS’ ability to visualize the tumor’s feeding vessels and vascular borders in real-time, with a level of detail unprecedented by conventional MRI-sequences. During awake resections, fUS was able to detect distinct, ESM-confirmed functional areas as activated during conventional motor and language tasks. In all cases, images were acquired with micrometer-millisecond (300 µm, 1.5–2.0 ms) precision at imaging depths exceeding 5 cm. CONCLUSION fUS is a new real-time, high-resolution and depth-resolved imaging technique, combining favorable imaging specifications with characteristics such as mobility and ease of use which are uniquely beneficial for a potential image-guided neurosurgical tool.

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