Photofrin mediated PDT in normal rat brain: assessment on apoptosis as a quantitative biological endpoint

2000 ◽  
Author(s):  
Lothar D. Lilge ◽  
Emily Ching ◽  
Michelle Portnoy ◽  
Andrea Molckovsky ◽  
Brian C. Wilson
Keyword(s):  
Rat Brain ◽  
Normal Rat ◽  
Biological Endpoint

Angiogenesis Induced by Photodynamic Therapy in Normal Rat Brain¶

2004 ◽  
Vol 79 (6) ◽  
pp. 494 ◽  
Author(s):  
Feng Jiang ◽  
Zheng Gang Zhang ◽  
Mark Katakowski ◽  
Adam M Robin ◽  
Michelle Faber ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Rat Brain ◽  
Normal Rat

scholarly journals High Glycogen Levels in Brains of Rats with Minimal Environmental Stimuli: Implications for Metabolic Contributions of Working Astrocytes

2002 ◽  
Vol 22 (12) ◽  
pp. 1476-1489 ◽  
Author(s):  
Nancy F. Cruz ◽  
Gerald A. Dienel
Keyword(s):  
Rat Brain ◽  
Sensory Stimulation ◽  
Enzyme Inactivation ◽  
Biologically Active ◽  
Metabolic Labeling ◽  
Tissue Sampling ◽  
Normal Rat ◽  
Sampling Procedures ◽  
Very High

The concentration of glycogen, the major brain energy reserve localized mainly in astrocytes, is generally reported as about 2 or 3 μmol/g, but sometimes as high as 3.9 to 8 μmol/g, in normal rat brain. The authors found high but very different glycogen levels in two recent studies in which glycogen was determined by the routine amyloglucosidase procedure in 0.03N HCl digests either of frozen powders (4.8 to 6 μmol/g) or of ethanol-insoluble fractions (8 to 12 μmol/g). To evaluate the basis for these discrepant results, glycogen was assayed in parallel extracts of the same samples. Glycogen levels in ethanol extracts were twice those in 0.03N HCl digests, suggesting incomplete enzyme inactivation even with very careful thawing. The very high glycogen levels were biologically active and responsive to physiologic and pharmacological challenge. Glycogen levels fell after brief sensory stimulation, and metabolic labeling indicated its turnover under resting conditions. About 95% of the glycogen was degraded under in vitro ischemic conditions, and its “carbon equivalents” recovered mainly as glc, glc-P, and lactate. Resting glycogen stores were reduced by about 50% by chronic inhibition of nitric oxide synthase. Because neurotransmitters are known to stimulate glycogenolysis, stress or sensory activation due to animal handling and tissue-sampling procedures may stimulate glycogenolysis during an experiment, and glycogen lability during tissue sampling and extraction can further reduce glycogen levels. The very high glycogen levels in normal rat brain suggest an unrecognized role for astrocytic energy metabolism during brain activation.

Expression of interleukin (IL)-1β, IL-6 and their respective receptors in the normal rat brain and after injury

1992 ◽  
Vol 22 (11) ◽  
pp. 2963-2971 ◽  
Author(s):  
Hong Qu Yan ◽  
Miguel Alcaros Banos ◽  
Patrick Herregodts ◽  
Robert Hooghe ◽  
Elisabeth L. Hooghe-Peters
Keyword(s):  
Rat Brain ◽  
Normal Rat

Ultrastructural localization of amyloid β/A4 protein precursor in the normal rat brain

1993 ◽  
Vol 63 (1) ◽  
pp. 173-180 ◽  
Author(s):  
Tsuneo Yamazaki ◽  
Haruyasu Yamaguchi ◽  
Takeshi Kawarabayashi ◽  
Shunsaku Hirai
Keyword(s):  
Rat Brain ◽  
Amyloid Β ◽  
Ultrastructural Localization ◽  
Protein Precursor ◽  
Normal Rat

Intracellular pH Regulation of Normal Rat Brain: 31P-MRS Study

1990 ◽  
pp. 25-27
Author(s):  
F. Ohta ◽  
K. Moritake ◽  
T. Kagawa ◽  
M. Fukuda ◽  
A. Fukuma
Keyword(s):  
Rat Brain ◽  
Intracellular Ph ◽  
Ph Regulation ◽  
Intracellular Ph Regulation ◽  
31P Mrs ◽  
Normal Rat

EFFECTS OF LIGHT BEAM SIZE ON FLUENCE DISTRIBUTION AND DEPTH OF NECROSIS IN SUPERFICIALLY APPLIED PHOTODYNAMIC THERAPY OF NORMAL RAT BRAIN

1992 ◽  
Vol 56 (3) ◽  
pp. 379-384 ◽  
Author(s):  
Qun Chen ◽  
Brian C. Wilson ◽  
Mary O. Dereski ◽  
Michael S. Patterson ◽  
Michael Chopp ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Rat Brain ◽  
Light Beam ◽  
Beam Size ◽  
Normal Rat

Histologic study of normal rat brain tissue after neodymiumyttrium aluminum garnet laser irradiation. I. Cerebral hemisphere

1985 ◽  
Vol 23 (5) ◽  
pp. 475-482 ◽  
Author(s):  
Tatsuhito Yamagami ◽  
Hajime Handa ◽  
Juji Takeuchi ◽  
Nobuo Hashimoto ◽  
Waro Taki ◽  
...  
Keyword(s):  
Rat Brain ◽  
Laser Irradiation ◽  
Brain Tissue ◽  
Cerebral Hemisphere ◽  
Histologic Study ◽  
Normal Rat ◽  
Rat Brain Tissue

The Effect of Light Fluence Rate in Photodynamic Therapy of Normal Rat Brain

1992 ◽  
Vol 132 (1) ◽  
pp. 120 ◽  
Author(s):  
Q. Chen ◽  
M. Chopp ◽  
M. O. Dereski ◽  
B. C. Wilson ◽  
M. S. Patterson ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Rat Brain ◽  
Fluence Rate ◽  
Light Fluence ◽  
Normal Rat ◽  
Effect Of Light
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