The Effect of Light Fluence Rate in Photodynamic Therapy of Normal Rat Brain

1992 ◽  
Vol 132 (1) ◽  
pp. 120 ◽  
Author(s):  
Q. Chen ◽  
M. Chopp ◽  
M. O. Dereski ◽  
B. C. Wilson ◽  
M. S. Patterson ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Rat Brain ◽  
Fluence Rate ◽  
Light Fluence ◽  
Normal Rat ◽  
Effect Of Light

Angiogenesis Induced by Photodynamic Therapy in Normal Rat Brain¶

2004 ◽  
Vol 79 (6) ◽  
pp. 494 ◽  
Author(s):  
Feng Jiang ◽  
Zheng Gang Zhang ◽  
Mark Katakowski ◽  
Adam M Robin ◽  
Michelle Faber ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Rat Brain ◽  
Normal Rat

Photodynamic Therapy at Low-Light Fluence Rate: in vitro Assays on Colon Cancer Cells

2019 ◽  
Vol 25 (1) ◽  
pp. 1-6 ◽  
Author(s):  
J. A. Rodrigues ◽  
R. Amorim ◽  
M. F. Silva ◽  
F. Baltazar ◽  
R. F. Wolffenbuttel ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Fluence Rate ◽  
Colon Cancer Cells ◽  
Low Light ◽  
Light Fluence

EFFECTS OF LIGHT BEAM SIZE ON FLUENCE DISTRIBUTION AND DEPTH OF NECROSIS IN SUPERFICIALLY APPLIED PHOTODYNAMIC THERAPY OF NORMAL RAT BRAIN

1992 ◽  
Vol 56 (3) ◽  
pp. 379-384 ◽  
Author(s):  
Qun Chen ◽  
Brian C. Wilson ◽  
Mary O. Dereski ◽  
Michael S. Patterson ◽  
Michael Chopp ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Rat Brain ◽  
Light Beam ◽  
Beam Size ◽  
Normal Rat

Toxicity of photodynamic therapy with photofrin in the normal rat brain

1994 ◽  
Vol 14 (3) ◽  
pp. 219-228 ◽  
Author(s):  
Ying Ji ◽  
Stephen K. Powers ◽  
J. Tony Brown ◽  
Diana Walstad ◽  
Lloyd Maliner
Keyword(s):  
Photodynamic Therapy ◽  
Rat Brain ◽  
Normal Rat

Angiogenesis Induced by Photodynamic Therapy in Normal Rat Brain¶

2007 ◽  
Vol 79 (6) ◽  
pp. 494-499 ◽  
Author(s):  
Feng Jiang ◽  
Zheng Gang Zhang ◽  
Mark Katakowski ◽  
Adam M Robin ◽  
Michelle Faber ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Rat Brain ◽  
Normal Rat

scholarly journals Measurement of Cyanine Dye Photobleaching in Photosensitizer Cyanine Dye Conjugates Could Help in Optimizing Light Dosimetry for Improved Photodynamic Therapy of Cancer

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 1842 ◽  
Author(s):  
Nadine James ◽  
Ravindra Cheruku ◽  
Joseph Missert ◽  
Ulas Sunar ◽  
Ravindra Pandey
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Tumor Response ◽  
Cyanine Dye ◽  
Fluence Rate ◽  
Low Light ◽  
Light Dosimetry ◽  
Light Fluence ◽  
Photodynamic Therapy Of Cancer

Photodynamic therapy (PDT) of cancer is dependent on three primary components: photosensitizer (PS), light and oxygen. Because these components are interdependent and vary during the dynamic process of PDT, assessing PDT efficacy may not be trivial. Therefore, it has become necessary to develop pre-treatment planning, on-line monitoring and dosimetry strategies during PDT, which become more critical for two or more chromophore systems, for example, PS-CD (Photosensitizer-Cyanine dye) conjugates developed in our laboratory for fluorescence-imaging and PDT of cancer. In this study, we observed a significant impact of variable light dosimetry; (i) high light fluence and fluence rate (light dose: 135 J/cm2, fluence rate: 75 mW/cm2) and (ii) low light fluence and fluence rate (128 J/cm2 and 14 mW/cm2 and 128 J/cm2 and 7 mW/cm2) in photobleaching of the individual chromophores of PS-CD conjugates and their long-term tumor response. The fluorescence at the near-infrared (NIR) region of the PS-NIR fluorophore conjugate was assessed intermittently via fluorescence imaging. The loss of fluorescence, photobleaching, caused by singlet oxygen from the PS was mapped continuously during PDT. The tumor responses (BALB/c mice bearing Colon26 tumors) were assessed after PDT by measuring tumor sizes daily. Our results showed distinctive photobleaching kinetics rates between the PS and CD. Interestingly, compared to higher light fluence, the tumors exposed at low light fluence showed reduced photobleaching and enhanced long-term PDT efficacy. The presence of NIR fluorophore in PS-CD conjugates provides an opportunity of fluorescence imaging and monitoring the photobleaching rate of the CD moiety for large and deeply seated tumors and assessing PDT tumor response in real-time.

In vivo optical properties of normal rat brain and application in photodynamic therapy

1990 ◽  
Vol 19 ◽  
pp. 259
Author(s):  
Q. Chen ◽  
M.O. Dereski ◽  
B. Wilson ◽  
M. Patterson ◽  
M. Chopp ◽  
...  
Keyword(s):  
Optical Properties ◽  
Photodynamic Therapy ◽  
Rat Brain ◽  
Normal Rat
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