Near-infrared spectroscopic reflectance imaging: methods for functional imaging and in-vivo monitoring

1999 ◽  
Author(s):  
James R. Mansfield ◽  
Michael G. Sowa ◽  
Henry H. Mantsch
Keyword(s):  
Functional Imaging ◽  
Near Infrared ◽  
Imaging Methods ◽  
In Vivo Monitoring ◽  
Infrared Spectroscopic

scholarly journals Assessment of Endothelin-A Receptor Expression in Subcutaneous and Orthotopic Thyroid Carcinoma Xenografts in Vivo Employing Optical Imaging Methods

Endocrinology ◽  
2012 ◽  
Vol 153 (6) ◽  
pp. 2907-2918 ◽  
Author(s):  
Katrin Büther ◽  
Matthijs G. Compeer ◽  
Jo G. R. De Mey ◽  
Otmar Schober ◽  
Michael Schäfers ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Optical Imaging ◽  
Near Infrared ◽  
Functional Performance ◽  
Thyroid Tumor ◽  
Receptor Expression ◽  
Imaging Methods ◽  
Carcinoma Cell Lines ◽  
Isolated Artery

Endothelin (ET) receptor dysregulation has been described in a number of pathophysiological processes, including cardiovascular disorders, renal failure, and cancer. The aim of this study was to evaluate the expression of the ET-A receptor (ETAR) in murine models of thyroid carcinoma using optical imaging methods. A recently developed near-infrared fluorescent tracer was first assessed in isolated artery preparations for its functional performance in comparison with known ETAR antagonists BQ123 and PD156707. Before evaluation of the tracer in vivo, different thyroid carcinoma cell lines were characterized with respect to their ET receptor expression by RT-PCR and autoradiography. In vivo, sc and orthotopic papillary thyroid tumor xenografts were clearly visualized by fluorescence reflectance imaging and fluorescence-mediated tomography up to 48 h after injection of the tracer. Binding specificity of the probe was demonstrated by predosing with PD156707 as a competing inhibitor. In conclusion, optical imaging with a fluorescent ETAR tracer allows the noninvasive imaging of tumor-associated ETAR expression in vivo. In the future, this technique may help surgeons to evaluate lesion dimensions in intraoperative settings (e.g. thyroidectomy).

In Vivo Monitoring of Intravenously Injected Gold Nanorods Using Near‐Infrared Light

Small ◽  
2008 ◽  
Vol 4 (7) ◽  
pp. 1001-1007 ◽  
Author(s):  
Takuro Niidome ◽  
Yasuyuki Akiyama ◽  
Kohei Shimoda ◽  
Takahito Kawano ◽  
Takeshi Mori ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
In Vivo Monitoring

scholarly journals Towards a wearable near infrared spectroscopic probe for monitoring concentrations of multiple chromophores in biological tissue in vivo

2016 ◽  
Vol 87 (6) ◽  
pp. 065112 ◽  
Author(s):  
Danial Chitnis ◽  
Dimitrios Airantzis ◽  
David Highton ◽  
Rhys Williams ◽  
Phong Phan ◽  
...  
Keyword(s):  
Biological Tissue ◽  
Near Infrared ◽  
Infrared Spectroscopic ◽  
Spectroscopic Probe

Long-wavelength near-infrared spectroscopic imaging for in-vivo skin hydration measurements

2002 ◽  
Vol 28 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Michael Attas ◽  
Trevor Posthumus ◽  
Bernie Schattka ◽  
Michael Sowa ◽  
Henry Mantsch ◽  
...  
Keyword(s):  
Near Infrared ◽  
Spectroscopic Imaging ◽  
Skin Hydration ◽  
Long Wavelength ◽  
Infrared Spectroscopic ◽  
Infrared Spectroscopic Imaging

scholarly journals A transvaginal probe for near infrared spectroscopic monitoring of the bladder detrusor muscle and urethral sphincter

2008 ◽  
Vol 22 (6) ◽  
pp. 429-436 ◽  
Author(s):  
Babak Shadgan ◽  
Lynn Stothers ◽  
Andrew Macnab
Keyword(s):  
Near Infrared ◽  
Bladder Wall ◽  
Design Criteria ◽  
Detrusor Muscle ◽  
Urethral Sphincter ◽  
Small Series ◽  
Infrared Spectroscopic ◽  
Movement Artifact ◽  
Bladder Detrusor

The majority ofin vivoapplications of near infrared spectroscopic (NIRS) monitoring use transcutaneous optode placement over the tissue of interest. Invasive application of optodes is occasionally described for monitoring tissue too deep for transcutaneous study, principally in animal models, but sometimes in humans. Invasive fibre-optic probes have been developed for a range of other spectroscopic applications including somein vivo. We describe the design and feasibility testing in a human subject of a vaginal probe to extend the scope of recently developed techniques for NIRS monitoring in urology.Design criteria included: use of optodes and cables with dimensions compatible with appropriate overall probe size; dual channel capability (for simultaneous monitoring of bladder wall and urethral sphincter); secure interoptode separation at correct distance for required penetration; ease of insertion, orientation and avoidance of movement artifact.Components were obtained that met design criteria and allowed use of the probe connected to a commercial NIRS instrument. Iterative development established optimal interoptode distance and secure positioning of a probe that could be housed forin vivostudy within a disposable vaginal speculum.The feasibility of monitoring changes in chromophore concentration in the bladder detrusor and urethral sphincter using this intravaginal probe was evident from four separate studies during voiding and a series of physiologic events (cough, Valsalva and Kiegel contractions) in a healthy female volunteer. This small series suggests that reproducible data free of movement artifact, with consistent patterns and magnitudes of chromophore change can be obtained with the probe designed.

scholarly journals In Vivo Monitoring of Cutaneous Edema using Spectral Imaging in the Visible and Near Infrared

2006 ◽  
Vol 126 (8) ◽  
pp. 1753-1760 ◽  
Author(s):  
Georgios N. Stamatas ◽  
Michael Southall ◽  
Nikiforos Kollias
Keyword(s):  
Near Infrared ◽  
Spectral Imaging ◽  
In Vivo Monitoring
Sign in / Sign up

Export Citation Format

Share Document