scholarly journals Towards a wearable near infrared spectroscopic probe for monitoring concentrations of multiple chromophores in biological tissue in vivo

2016 ◽  
Vol 87 (6) ◽  
pp. 065112 ◽  
Author(s):  
Danial Chitnis ◽  
Dimitrios Airantzis ◽  
David Highton ◽  
Rhys Williams ◽  
Phong Phan ◽  
...  
Keyword(s):  
Biological Tissue ◽  
Near Infrared ◽  
Infrared Spectroscopic ◽  
Spectroscopic Probe

Long-wavelength near-infrared spectroscopic imaging for in-vivo skin hydration measurements

2002 ◽  
Vol 28 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Michael Attas ◽  
Trevor Posthumus ◽  
Bernie Schattka ◽  
Michael Sowa ◽  
Henry Mantsch ◽  
...  
Keyword(s):  
Near Infrared ◽  
Spectroscopic Imaging ◽  
Skin Hydration ◽  
Long Wavelength ◽  
Infrared Spectroscopic ◽  
Infrared Spectroscopic Imaging

scholarly journals A transvaginal probe for near infrared spectroscopic monitoring of the bladder detrusor muscle and urethral sphincter

2008 ◽  
Vol 22 (6) ◽  
pp. 429-436 ◽  
Author(s):  
Babak Shadgan ◽  
Lynn Stothers ◽  
Andrew Macnab
Keyword(s):  
Near Infrared ◽  
Bladder Wall ◽  
Design Criteria ◽  
Detrusor Muscle ◽  
Urethral Sphincter ◽  
Small Series ◽  
Infrared Spectroscopic ◽  
Movement Artifact ◽  
Bladder Detrusor

The majority ofin vivoapplications of near infrared spectroscopic (NIRS) monitoring use transcutaneous optode placement over the tissue of interest. Invasive application of optodes is occasionally described for monitoring tissue too deep for transcutaneous study, principally in animal models, but sometimes in humans. Invasive fibre-optic probes have been developed for a range of other spectroscopic applications including somein vivo. We describe the design and feasibility testing in a human subject of a vaginal probe to extend the scope of recently developed techniques for NIRS monitoring in urology.Design criteria included: use of optodes and cables with dimensions compatible with appropriate overall probe size; dual channel capability (for simultaneous monitoring of bladder wall and urethral sphincter); secure interoptode separation at correct distance for required penetration; ease of insertion, orientation and avoidance of movement artifact.Components were obtained that met design criteria and allowed use of the probe connected to a commercial NIRS instrument. Iterative development established optimal interoptode distance and secure positioning of a probe that could be housed forin vivostudy within a disposable vaginal speculum.The feasibility of monitoring changes in chromophore concentration in the bladder detrusor and urethral sphincter using this intravaginal probe was evident from four separate studies during voiding and a series of physiologic events (cough, Valsalva and Kiegel contractions) in a healthy female volunteer. This small series suggests that reproducible data free of movement artifact, with consistent patterns and magnitudes of chromophore change can be obtained with the probe designed.

scholarly journals Optical penetration of surface-enhanced micro-scale spatial offset Raman spectroscopy in turbid gel and biological tissue

2021 ◽  
pp. 2141001
Author(s):  
Yumin Zhang ◽  
Li Lin ◽  
Jing He ◽  
Jian Ye
Keyword(s):  
Raman Spectroscopy ◽  
Optical Fiber ◽  
Biological Tissue ◽  
Near Infrared ◽  
Surface Enhanced Raman Spectroscopy ◽  
Agarose Gel ◽  
Porcine Muscle ◽  
Micro Scale ◽  
Surface Enhanced

The limited penetration of photons in biological tissue restricts the deep-tissue detection and imaging application. The micro-scale spatially offset Raman spectroscopy (micro-SORS) with an optical fiber probe, colleting photons from deeper regions by offsetting the position of laser excitation from the collection optics in a range of hundreds of microns, shows great potential to be integrated with endoscopy for inside-body noninvasive detection by circumventing this restriction, particularly with the combination of surface-enhanced Raman spectroscopy (SERS). However, a detailed tissue penetration study of micro-SORS in combination with SERS is still lacking. Herein, we compared the signal decay of enhanced Raman nanotags through the tissue phantom of agarose gel and the biological tissue of porcine muscle in the near-infrared (NIR) region using a portable Raman spectrometer with a micro-SORS probe (2.1[Formula: see text]mm in diameter) and a conventional hand-held probe (9.7[Formula: see text]mm in diameter). Two kinds of Raman nanotags were prepared from gold nanorods decorated with the nonresonant (4-nitrobenzenethiol) or resonant Raman reporter molecules (IR-780 iodide). The SERS measurements show that the penetration depths of two Raman nanotags are both over 2[Formula: see text]cm in agarose gel and 3[Formula: see text]mm in porcine muscle. The depth could be improved to over 4[Formula: see text]cm in agarose gel and 5[Formula: see text]mm in porcine tissue when using the micro-SORS system. This demonstrates the superiority of optical-fiber micro-SORS system over the conventional Raman detection for the detection of nanotags in deeper layers in the turbid medium and biological tissue, offering the possibility of combining the micro-SORS technique with SERS for noninvasive in vivo endoscopy-integrated clinical application.

Development of a handheld near-infrared imager for dynamic characterization of in vivo biological tissue systems

2007 ◽  
Vol 46 (30) ◽  
pp. 7442 ◽  
Author(s):  
Ronald X. Xu ◽  
Bo Qiang ◽  
Jimmy J. Mao ◽  
Stephen P. Povoski
Keyword(s):  
Biological Tissue ◽  
Near Infrared ◽  
Dynamic Characterization ◽  
Infrared Imager ◽  
Tissue Systems
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