Enhancement of photodynamic therapy due to hyperbaric hyperoxia: an experimental study of Walker 256 tumors in rats

1997 ◽  
Author(s):  
Jorge H. Nicola ◽  
Valdir C. Colussi ◽  
Ester M. D. Nicola ◽  
Konradin Metze
Keyword(s):  
Experimental Study ◽  
Photodynamic Therapy ◽  
Hyperbaric Hyperoxia ◽  
Walker 256 ◽  
Walker 256 Tumors

scholarly journals Imaging Experimental Brain Tumors with 1-Aminocyclopentane Carboxylic Acid and Alpha-Aminoisobutyric Acid: Comparison to Fluorodeoxyglucose and Diethylenetriaminepentaacetic Acid in Morphologically Defined Tumor Regions

1997 ◽  
Vol 17 (11) ◽  
pp. 1239-1253 ◽  
Author(s):  
Hisao Uehara ◽  
Tadashi Miyagawa ◽  
Juri Tjuvajev ◽  
Revathi Joshi ◽  
Bradley Beattie ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Brain Tumors ◽  
Vascular Permeability ◽  
Cell Density ◽  
Low Grade ◽  
Acid Uptake ◽  
Diethylenetriaminepentaacetic Acid ◽  
Experimental Brain Tumors ◽  
Walker 256 ◽  
Walker 256 Tumors

The goal of this study was to evaluate the differences and define the advantages of imaging experimental brain tumors in rats with two nonmetabolized amino acids, 1-aminocyclopentane carboxylic (ACPC) acid and α-aminoisobutyric (AIB) acid compared with imaging with fluorodeoxyglucose (FDG) or the gallium-diethylenetriaminepentaacetic acid chelate (Ga-DTPA). 1-aminocyclopentane carboxylic acid, AIB, and FDG autoradiograms were obtained 60 minutes after intravenous injection to simulate positron emission tomography (PET) imaging, whereas the Ga-DTPA autoradiograms were obtained 5 or 10 minutes after injection to simulate gadolinium (Gd)-DTPA–enhanced magnetic resonance (MR) images. Three experimental tumors were studied (C6, RG2, and Walker 256) to provide a range of tumor types. Triple-label quantitative autoradiography was performed, and parametric images of the apparent distribution volume (Va, mL/g) for ACPC or AIB, relative glucose metabolism (R, μmol/100 g/min), vascular permeability to Ga-DTPA (K1, μL/min/g), and histology were obtained from the same tissue section. The four images were registered in an image array processor, and regions of interest in tumor and contralateral brain were defined on morphologic criteria (histology) and were transferred to the autoradiographic images. A comparative analysis of all measured values was performed. The location and morphologic characteristics of the tumor had an effect on the images and measurements of Va, R, and K1. Meningeal extensions of all three tumors consistently had the highest amino acid uptake (Va) and vascular permeability (K1) values, and subcortical portions of the tumors usually had the lowest values. Va and R (FDG) values generally were higher in tumor regions with high-cell density and lower in regions with low-cell density. Tumor areas identified as “impending” necrosis on morphologic criteria consistently had high R values, but little or no change in Va or K1. Tumor necrosis was seen consistently only in the larger Walker 256 tumors; low values of R and Va for AIB (less for ACPC) were measured in the necrotic-appearing regions, whereas K1 was not different from the mean tumor value. The highest correlations were observed between vascular permeability (K1 for Ga-DTPA) and Va for AIB in all three tumors; little or no correlation between vascular permeability and R was observed. The advantages of ACPC and AIB imaging were most convincingly demonstrated in C6 gliomas and in Walker 256 tumors. 1-aminocyclopentane was substantially better than FDG or Ga-DTPA for identifying tumor infiltration of adjacent brain tissue beyond the macroscopic border of the tumor; ACPC also may be useful for identifying low-grade tumors with an intact blood–brain barrier. Contrast-enhancing regions of the tumors were visualized more clearly with AIB than with FDG or Ga-DTPA; viable and necrotic-appearing tumor regions could be distinguished more readily with AIB than with FDG. [11C]-labeled ACPC and AIB are likely to have similar advantages for imaging human brain tumors with PET.

scholarly journals AN EXPERIMENTAL STUDY OF WHOLE BLADDER WALL PHOTODYNAMIC THERAPY USING A LIGHT-SCATTERING MEDIUM

1988 ◽  
Vol 79 (5) ◽  
pp. 807-813
Author(s):  
Tadao Uchibayashi ◽  
Haruo Hisazumi ◽  
Toshiyasu Amano ◽  
Norio Miyoshi
Keyword(s):  
Experimental Study ◽  
Photodynamic Therapy ◽  
Light Scattering ◽  
Bladder Wall ◽  
Scattering Medium

Tumor-associated neurological dysfunction prevented by lazaroids in rats

1991 ◽  
Vol 74 (1) ◽  
pp. 112-115 ◽  
Author(s):  
Wesley A. King ◽  
Keith L. Black ◽  
Kiyonobu Ikezaki ◽  
Scott Conklin ◽  
Donald P. Becker
Keyword(s):  
Vascular Permeability ◽  
Tumor Model ◽  
Neurological Dysfunction ◽  
Control Group ◽  
Content Type ◽  
Brain Tumor Model ◽  
Walker 256 ◽  
Walker 256 Tumors ◽  
Fine Print ◽  
Better Than

✓ The efficacy of U-74006F and U-78517F in the treatment of blood-tumor barrier permeability and tumor-associated neurological dysfunction was evaluated in a brain-tumor model in rats. U-74006F is a 21-aminosteroid and U-78517F is a 2-methylamino chroman. Rats with stereotactically implanted Walker 256 tumors were treated with methylprednisolone, U-74006F, U-78517F, or vehicle (0.05 N HCl) on Days 6 through 10 following implantation. Neurological function and vascular permeability were assessed on Day 10. Methylprednisolone and U-74006F were equally effective at preventing neurological dysfunction compared to the control group (p < 0.01); U-78517F was slightly less effective than U-74006F and methylprednisolone but was significantly better than vehicle in preventing neurological dysfunction. Delivery of methylprednisolone resulted in a significant decrease in tumor vascular permeability (p < 0.006) while U-74006F and U-78517F had no effect on permeability. This suggests that U-74006F and U-78517F prevented tumor-associated neurological dysfunction by a mechanism other than decreasing permeability in tumor capillaries, and that U-74006F or U-78517F could prove useful in the treatment of brain tumors.

Effect of Axial Length on Laser Spot Size During Photodynamic Therapy: An Experimental Study in Monkeys

2006 ◽  
Vol 141 (1) ◽  
pp. 214-215 ◽  
Author(s):  
Mineo Kondo ◽  
Yasuki Ito ◽  
Kentaro Miyata ◽  
Nagako Kondo ◽  
Kohei Ishikawa ◽  
...  
Keyword(s):  
Experimental Study ◽  
Photodynamic Therapy ◽  
Axial Length ◽  
Spot Size ◽  
Laser Spot ◽  
Laser Spot Size

Efficacy of 5-aminolevulinic acid based photodynamic therapy in pituitary adenomas—experimental study on rat and human cell cultures

2016 ◽  
Vol 14 ◽  
pp. 77-83 ◽  
Author(s):  
Lisa Margarete Neumann ◽  
Kerim Beseoglu ◽  
Philipp Joerg Slotty ◽  
Brigitte Senger ◽  
Marcel Alexander Kamp ◽  
...  
Keyword(s):  
Experimental Study ◽  
Photodynamic Therapy ◽  
Cell Cultures ◽  
Human Cell ◽  
Pituitary Adenomas ◽  
Aminolevulinic Acid ◽  
Human Cell Cultures

Laser blood flowmetry in malignant tumors during photodynamic therapy: an experimental study

1994 ◽  
Author(s):  
Peter Sieg ◽  
Juergen Rosperich ◽  
Alex Walther ◽  
Swantje Pfleumer
Keyword(s):  
Experimental Study ◽  
Photodynamic Therapy ◽  
Malignant Tumors ◽  
Blood Flowmetry

scholarly journals The Morphological Evaluation of Walker 256 Tumors after Antiangiogenetic Therapy in Rats

2014 ◽  
Vol 71 (2) ◽  
Author(s):  
Alexandra IRIMIE ◽  
Attila Tamas SZORA ◽  
Mihai SOCAIU ◽  
Alexandru Flaviu TĂBĂRAN ◽  
Raluca VIDRIGHINESCU ◽  
...  
Keyword(s):  
Morphological Evaluation ◽  
Walker 256 ◽  
Antiangiogenetic Therapy ◽  
Walker 256 Tumors
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