Talking to the brain in its own language: a new approach to treating blindness

2021 ◽  
Author(s):  
Sheila Nirenberg
Keyword(s):  
New Approach ◽  
The Brain

Switching on swallowing, switching on the brain: A new approach for the treatment of dysphagia after stroke

2001 ◽  
Vol 120 (5) ◽  
pp. A713-A713
Author(s):  
M POWER ◽  
C FRASER ◽  
S HAMDY ◽  
P TYRELL ◽  
J ROTHWELL ◽  
...  
Keyword(s):  
New Approach ◽  
The Brain

Potential immunotherapy for Alzheimer disease and age-related dementia

2019 ◽  
Vol 21 (1) ◽  
pp. 21-25 ◽  
Keyword(s):  
Immune System ◽  
Alzheimer Disease ◽  
Cross Talk ◽  
Immune Checkpoint ◽  
Short Review ◽  
Immune Checkpoint Blockade ◽  
Checkpoint Blockade ◽  
New Approach ◽  
Age Related ◽  
The Brain

Emerging results support the concept that Alzheimer disease (AD) and age-related dementia are affected by the ability of the immune system to contain the brain's pathology. Accordingly, well-controlled boosting, rather than suppression of systemic immunity, has been suggested as a new approach to modify disease pathology without directly targeting any of the brain's disease hallmarks. Here, we provide a short review of the mechanisms orchestrating the cross-talk between the brain and the immune system. We then discuss how immune checkpoint blockade directed against the PD-1/PD-L1 pathways could be developed as an immunotherapeutic approach to combat this disease using a regimen that will address the needs to combat AD.

Potential immunotherapy for Alzheimer disease and age-related dementia

2019 ◽  
Vol 21 (1) ◽  
pp. 21-25 ◽  
Keyword(s):  
Immune System ◽  
Alzheimer Disease ◽  
Cross Talk ◽  
Immune Checkpoint ◽  
Short Review ◽  
Immune Checkpoint Blockade ◽  
Checkpoint Blockade ◽  
New Approach ◽  
Age Related ◽  
The Brain

Emerging results support the concept that Alzheimer disease (AD) and age-related dementia are affected by the ability of the immune system to contain the brain’s pathology. Accordingly, well-controlled boosting, rather than suppression of systemic immunity, has been suggested as a new approach to modify disease pathology without directly targeting any of the brain’s disease hallmarks. Here, we provide a short review of the mechanisms orchestrating the cross-talk between the brain and the immune system. We then discuss how immune checkpoint blockade directed against the PD-1/PD-L1 pathways could be developed as an immunotherapeutic approach to combat this disease using a regimen that will address the needs to combat AD.

A new approach to the molecular basis of neoplastic transformation in the brain

1992 ◽  
Vol 18 (5) ◽  
pp. 443-453 ◽  
Author(s):  
O. D. WIESTLER ◽  
O. BRÜSTLE ◽  
R. H. EIBL ◽  
H. RADNER ◽  
A. VON DEIMLING ◽  
...  
Keyword(s):  
Molecular Basis ◽  
Neoplastic Transformation ◽  
New Approach ◽  
The Brain

Redirecting adult mesenchymal stromal cells to the brain: a new approach for treating CNS autoimmunity and neuroinflammation?

2018 ◽  
Vol 96 (4) ◽  
pp. 347-357
Author(s):  
Jasmine J Wilson ◽  
Kerrie L Foyle ◽  
Jade Foeng ◽  
Todd Norton ◽  
Duncan R McKenzie ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
New Approach ◽  
Cns Autoimmunity ◽  
The Brain

Where Is the Beat? The Neural Correlates of Lexical Stress and Rhythmical Well-formedness in Auditory Story Comprehension

2017 ◽  
Vol 29 (7) ◽  
pp. 1119-1131 ◽  
Author(s):  
Katerina D. Kandylaki ◽  
Karen Henrich ◽  
Arne Nagels ◽  
Tilo Kircher ◽  
Ulrike Domahs ◽  
...  
Keyword(s):  
Stress Pattern ◽  
Lexical Stress ◽  
Story Comprehension ◽  
Speech Comprehension ◽  
New Approach ◽  
Sensorimotor Network ◽  
Electrophysiological Studies ◽  
Stress Patterns ◽  
Domain Independent ◽  
The Brain

While listening to continuous speech, humans process beat information to correctly identify word boundaries. The beats of language are stress patterns that are created by combining lexical (word-specific) stress patterns and the rhythm of a specific language. Sometimes, the lexical stress pattern needs to be altered to obey the rhythm of the language. This study investigated the interplay of lexical stress patterns and rhythmical well-formedness in natural speech with fMRI. Previous electrophysiological studies on cases in which a regular lexical stress pattern may be altered to obtain rhythmical well-formedness showed that even subtle rhythmic deviations are detected by the brain if attention is directed toward prosody. Here, we present a new approach to this phenomenon by having participants listen to contextually rich stories in the absence of a task targeting the manipulation. For the interaction of lexical stress and rhythmical well-formedness, we found one suprathreshold cluster localized between the cerebellum and the brain stem. For the main effect of lexical stress, we found higher BOLD responses to the retained lexical stress pattern in the bilateral SMA, bilateral postcentral gyrus, bilateral middle fontal gyrus, bilateral inferior and right superior parietal lobule, and right precuneus. These results support the view that lexical stress is processed as part of a sensorimotor network of speech comprehension. Moreover, our results connect beat processing in language to domain-independent timing perception.

scholarly journals The Geometry of Information Coding in Correlated Neural Populations

2021 ◽  
Vol 44 (1) ◽  
Author(s):  
Rava Azeredo da Silveira ◽  
Fred Rieke
Keyword(s):  
Neural Coding ◽  
Neural Population ◽  
Annual Review ◽  
Publication Date ◽  
Information Coding ◽  
Population Code ◽  
New Approach ◽  
Neural Populations ◽  
The Brain ◽  
Theoretical Developments

Neurons in the brain represent information in their collective activity. The fidelity of this neural population code depends on whether and how variability in the response of one neuron is shared with other neurons. Two decades of studies have investigated the influence of these noise correlations on the properties of neural coding. We provide an overview of the theoretical developments on the topic. Using simple, qualitative, and general arguments, we discuss, categorize, and relate the various published results. We emphasize the relevance of the fine structure of noise correlation, and we present a new approach to the issue. Throughout this review, we emphasize a geometrical picture of how noise correlations impact the neural code. Expected final online publication date for the Annual Review of Neuroscience, Volume 44 is July 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

scholarly journals Product innovation design and its method: From the perspective of embodiment cognition

2021 ◽  
Vol 236 ◽  
pp. 04057
Author(s):  
Shengfang Peng ◽  
Baoying Peng ◽  
Xiaoxuan Li
Keyword(s):  
Cognitive Psychology ◽  
Embodied Cognition ◽  
Human Body ◽  
Product Innovation ◽  
Natural Interaction ◽  
New Approach ◽  
The Subject ◽  
Body Complex ◽  
The Mind ◽  
The Brain

In recent years, embodied cognition has become a new approach in the field of cognitive psychology. The shift in cognitive psychology from a focus on the brain to a focus on the human body，just as from the disembodied cognition to the embodied cognition is valuable for many fields related to cognitive science including product design and its method. With Gibson’s theory of affordances, embodied cognition is a perfect explanation of today’s products guided by the idea of intuitive design and its logic. On the premise of embodied cognition, it is the “Mind-Body complex” that serves as the subject of behavior and interaction, the basis of “natural interaction” in Intelligent age, and the foundation for building a more complete theory of “user experience”. Based on the embodied cognitive, the method of design and its research should put more emphasis on specific tools.

Greater Occipital Nerve Stimulation Boosts Associative Memory in Older Individuals: A Randomized Trial

2020 ◽  
Vol 34 (11) ◽  
pp. 1020-1029
Author(s):  
Alison M. Luckey ◽  
S. Lauren McLeod ◽  
Ian H. Robertson ◽  
Wing Ting To ◽  
Sven Vanneste
Keyword(s):  
The Other ◽  
Transcutaneous Electrical Stimulation ◽  
Older Individuals ◽  
Occipital Nerve Stimulation ◽  
Double Blind ◽  
New Approach ◽  
Occipital Nerve ◽  
Randomized Design ◽  
Greater Occipital Nerve ◽  
The Brain

Transcutaneous electrical stimulation (tES) is a new approach that aims to stimulate the brain. Recently, we have developed tES approaches to enhance plasticity that modulate cortical activity via the greater occipital nerve (ON) in a “bottom-up” way. Thirty subjects between the ages of 55 and 70 years were enrolled and tested using a double-blind, sham-controlled, and randomized design. Half of the participants received active stimulation, while the other half received sham stimulation. Our results demonstrate that ON-tES can enhance memory in older individuals after one session, with effects persisting up to 28 days after stimulation. The hypothesized mechanism by which ON-tES enhances memory is activation of the locus coeruleus–noradrenaline (LC-NA) pathway. It is likely that this pathway was activated after ON-tES, as supported by observed changes in α-amylase concentrations, a biomarker for noradrenaline. There were no significant or long-lasting side effects observed during stimulation. Clinicaltrial.gov (NCT03467698).

scholarly journals MEDICINAL HERBS AND PHYTOCHEMICALS USED IN THE TREATMENT OF DEPRESSION: A REVIEW

2019 ◽  
pp. 8-14
Author(s):  
APOORVA HA ◽  
SEEMA MEHDI ◽  
KRISHNA KL ◽  
NABEEL K
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
Clinical Evidence ◽  
Emotional State ◽  
Well Being ◽  
New Approach ◽  
Treatment Of Depression ◽  
Primary Hypothesis ◽  
The Brain ◽  
Additional Option

Depression is a condition of no mood and loss of interest in any activity that can diminish a person’s thinking, conduct, tendencies, emotional state, and a sense of well-being. Although there is a conventional class of medication which have been beneficial in the treatment of depression, current studies have reported having side effects which can be minimized by the intervention of herbs and phytochemicals. Most of the studies have proven the various mechanisms and have started to research a very ground-breaking method by glancing the ancient treatmen. Where this new approach of using the herbs and phytochemicals has shown better results alone and in combination with conventional drugs which has shown lesser adverse effects. The practice of phytomedicine is an additional option for the treatment of depression. In the various segments of treating the depression, the mainstream can be a breakthrough including phytoconstituents. In this aspect, there are many contributions for the treatment of the depression acting to the neuronal level signaling and the phytoconstituents also have shown some basic mechanisms in the treatment of depression as that of the conventional medications following some primary hypothesis and signaling pathways and life interactions that effects the brain in either way to treat the depression in all sort of way. Clinical evidence is required to provide backing to the safety and effectiveness of herbs and phytochemicals alone or in combination with currently available drugs to overcome the reported side effects during the treatment of depression.

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