Redirecting adult mesenchymal stromal cells to the brain: a new approach for treating CNS autoimmunity and neuroinflammation?

2018 ◽  
Vol 96 (4) ◽  
pp. 347-357
Author(s):  
Jasmine J Wilson ◽  
Kerrie L Foyle ◽  
Jade Foeng ◽  
Todd Norton ◽  
Duncan R McKenzie ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
New Approach ◽  
Cns Autoimmunity ◽  
The Brain

scholarly journals Mesenchymal Stromal Cells Primed with Paclitaxel Provide a New Approach for Cancer Therapy

PLoS ONE ◽  
2011 ◽  
Vol 6 (12) ◽  
pp. e28321 ◽  
Author(s):  
Augusto Pessina ◽  
Arianna Bonomi ◽  
Valentina Coccè ◽  
Gloria Invernici ◽  
Stefania Navone ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
New Approach

Localization and Differentiation Pattern of Transplanted Human Multipotent Mesenchymal Stromal Cells in the Brain of Bulbectomized Mice

2014 ◽  
Vol 158 (1) ◽  
pp. 118-122 ◽  
Author(s):  
M. M. Panchenko ◽  
R. A. Poltavtseva ◽  
N. V. Bobkova ◽  
D. V. Vel’meshev ◽  
I. V. Nesterova ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Multipotent Mesenchymal Stromal Cells ◽  
Differentiation Pattern ◽  
The Brain

Distribution and Migration of Human Placental Mesenchymal Stromal Cells in the Brain of Healthy Rats after Stereotaxic or Intra-Arterial Transplantation

2020 ◽  
Vol 168 (4) ◽  
pp. 542-551
Author(s):  
K. K. Sukhinich ◽  
D. D. Namestnikova ◽  
I. L. Gubskii ◽  
A. N. Gabashvili ◽  
P. A. Mel’nikov ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
And Migration ◽  
The Brain

A New Approach to Evaluation of Osteogenic Potential of Mesenchymal Stromal Cells

2008 ◽  
Vol 146 (4) ◽  
pp. 534-539 ◽  
Author(s):  
A. A. Ostanin ◽  
Ya. L. Petrovskiy ◽  
E. Ya. Shevela ◽  
E. V. Kurganova ◽  
A. N. Drobinskaja ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Osteogenic Potential ◽  
New Approach

scholarly journals Detection of Intranasally Delivered Bone Marrow-Derived Mesenchymal Stromal Cells in the Lesioned Mouse Brain: A Cautionary Report

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Elena H. Chartoff ◽  
Diane Damez-Werno ◽  
Kai C. Sonntag ◽  
Linda Hassinger ◽  
Daniel E. Kaufmann ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Control Experiment ◽  
Fluorescent Protein ◽  
Detection Methods ◽  
Wild Type ◽  
Cellular Marker ◽  
Green Fluorescent ◽  
The Brain

Bone marrow-derived mesenchymal stromal cells (MSCs) hold promise for autologous treatment of neuropathologies. Intranasal delivery is relatively noninvasive and has recently been reported to result in transport of MSCs to the brain. However, the ability of MSCs to migrate from nasal passages to sites of neuropathology and ultimately survive has not been fully examined. In this paper, we harvested MSCs from transgenic mice expressing enhanced green fluorescent protein (cells hereafter referred to as MSC-EGFP) and delivered them intranasally to wild-type mice sustaining mechanical lesions in the striatum. Using fluorescent, colorimetric, and ultrastructural detection methods, GFP-expressing cells were undetectable in the brain from 3 hours to 2 months after MSC delivery. However, bright autofluorescence that strongly resembled emission from GFP was observed in the olfactory bulb and striatum of lesioned control and MSC-EGFP-treated mice. In a control experiment, we directly implanted MSC-EGFPs into the mouse striatum and detected robust GFP expression 1 and 7 days after implantation. These findings suggest that—under our conditions—intranasally delivered MSC-EGFPs do not survive or migrate in the brain. Furthermore, our observations highlight the necessity of including appropriate controls when working with GFP as a cellular marker.

Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: A new approach for drug delivery

2014 ◽  
Vol 192 ◽  
pp. 262-270 ◽  
Author(s):  
Luisa Pascucci ◽  
Valentina Coccè ◽  
Arianna Bonomi ◽  
Diletta Ami ◽  
Piero Ceccarelli ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Growth ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
New Approach

Switching on swallowing, switching on the brain: A new approach for the treatment of dysphagia after stroke

2001 ◽  
Vol 120 (5) ◽  
pp. A713-A713
Author(s):  
M POWER ◽  
C FRASER ◽  
S HAMDY ◽  
P TYRELL ◽  
J ROTHWELL ◽  
...  
Keyword(s):  
New Approach ◽  
The Brain
Sign in / Sign up

Export Citation Format

Share Document