Seeking new biomarkers with diffuse correlation spectroscopy and next generation devices for transcranial assessment of cerebral hemodynamics

2021 ◽  
Author(s):  
Turgut Durduran
Keyword(s):  
Cerebral Hemodynamics ◽  
Correlation Spectroscopy ◽  
Next Generation ◽  
Diffuse Correlation Spectroscopy ◽  
New Biomarkers

scholarly journals Cerebral Hemodynamics at Altitude Using Diffuse Correlation Spectroscopy and Transcranial Doppler

2012 ◽  
Vol 23 (2) ◽  
pp. 194
Author(s):  
Matthew R. Sanborn ◽  
Meeri N. Kim ◽  
Rickson Mesquita ◽  
Arjun Yodh ◽  
Mark E. Edsell ◽  
...  
Keyword(s):  
Transcranial Doppler ◽  
Cerebral Hemodynamics ◽  
Correlation Spectroscopy ◽  
Diffuse Correlation Spectroscopy

Double layer estimation of flow changes using diffuse correlation spectroscopy

2009 ◽  
Author(s):  
Louis Gagnon ◽  
Michèle Desjardins ◽  
Louis Bherer ◽  
Frédéric Lesage
Keyword(s):  
Double Layer ◽  
Correlation Spectroscopy ◽  
Diffuse Correlation Spectroscopy ◽  
Flow Changes

scholarly journals Non-invasive optical neuromonitoring of the temperature-dependence of cerebral oxygen metabolism during deep hypothermic cardiopulmonary bypass in neonatal swine

2018 ◽  
Vol 40 (1) ◽  
pp. 187-203 ◽  
Author(s):  
Tiffany S Ko ◽  
Constantine D Mavroudis ◽  
Wesley B Baker ◽  
Vincent C Morano ◽  
Kobina Mensah-Brown ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Temperature Response ◽  
Oxygen Metabolism ◽  
Correlation Spectroscopy ◽  
Neurological Injury ◽  
Diffuse Correlation Spectroscopy ◽  
Non Invasive ◽  
Neuroprotective Strategy ◽  
Subject Variability

Management of deep hypothermic (DH) cardiopulmonary bypass (CPB), a critical neuroprotective strategy, currently relies on non-invasive temperature to guide cerebral metabolic suppression during complex cardiac surgery in neonates. Considerable inter-subject variability in temperature response and residual metabolism may contribute to the persisting risk for postoperative neurological injury. To characterize and mitigate this variability, we assess the sufficiency of conventional nasopharyngeal temperature (NPT) guidance, and in the process, validate combined non-invasive frequency-domain diffuse optical spectroscopy (FD-DOS) and diffuse correlation spectroscopy (DCS) for direct measurement of cerebral metabolic rate of oxygen ( CMRO2). During CPB, n = 8 neonatal swine underwent cooling from normothermia to 18℃, sustained DH perfusion for 40 min, and then rewarming to simulate cardiac surgery. Continuous non-invasive and invasive measurements of intracranial temperature (ICT) and CMRO2 were acquired. Significant hysteresis ( p < 0.001) between cooling and rewarming periods in the NPT versus ICT and NPT versus CMRO2 relationships were found. Resolution of this hysteresis in the ICT versus CMRO2 relationship identified a crucial insufficiency of conventional NPT guidance. Non-invasive CMRO2 temperature coefficients with respect to NPT ( Q10 = 2.0) and ICT ( Q10 = 2.5) are consistent with previous reports and provide further validation of FD-DOS/DCS CMRO2 monitoring during DH CPB to optimize management.

scholarly journals Investigation of diffuse correlation spectroscopy in multi-layered media including the human head

2008 ◽  
Vol 16 (20) ◽  
pp. 15514 ◽  
Author(s):  
Louis Gagnon ◽  
Michèle Desjardins ◽  
Julien Jehanne-Lacasse ◽  
Louis Bherer ◽  
Frédéric Lesage
Keyword(s):  
Layered Media ◽  
Human Head ◽  
Correlation Spectroscopy ◽  
Diffuse Correlation Spectroscopy
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