scholarly journals Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound

2009 ◽  
Vol 17 (15) ◽  
pp. 12571 ◽  
Author(s):  
Erin M. Buckley ◽  
Noah M. Cook ◽  
Turgut Durduran ◽  
Meeri N. Kim ◽  
Chao Zhou ◽  
...  
2012 ◽  
Vol 23 (2) ◽  
pp. 194
Author(s):  
Matthew R. Sanborn ◽  
Meeri N. Kim ◽  
Rickson Mesquita ◽  
Arjun Yodh ◽  
Mark E. Edsell ◽  
...  

1992 ◽  
Vol 76 (6) ◽  
pp. 961-966 ◽  
Author(s):  
Cole A. Giller ◽  
Benjamin D. Levine ◽  
Yves Meyer ◽  
Jay C. Buckey ◽  
Lynda D. Lane ◽  
...  

✓ Although severe hypovolemia can lead to hypotension and neurological decline, many patients with neurosurgical disorders experience a significant hypovolemia while autonomic compensatory mechanisms maintain a normal blood pressure. To assess the effects of normotensive hypovolemia upon cerebral hemodynamics, transcranial Doppler ultrasound monitoring of 13 healthy volunteers was performed during graded lower-body negative pressure of up to −50 mm Hg, an accepted laboratory model for reproducing the physiological effects of hypovolemia. Middle cerebral artery flow velocity declined by 16% ± 4% (mean ± standard error of the mean) and the ratio between transcranial Doppler ultrasound pulsatility and systemic pulsatility rose 22% ± 8%, suggesting cerebral small-vessel vasoconstriction in response to the sympathetic activation unmasked by lower-body negative pressure. This vasoconstriction may interfere with the autoregulatory response to a sudden fall in blood pressure, and may explain the common observation of neurological deficit during hypovolemia even with a normal blood pressure.


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