Three-dimensional photoacoustic computed tomography for preclinical research and clinical translation

2021 ◽  
Author(s):  
Li Lin ◽  
Peng Hu ◽  
Xin Tong ◽  
Shuai Na ◽  
Rui Cao ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Three Dimensional ◽  
Clinical Translation ◽  
Preclinical Research

scholarly journals High-speed three-dimensional photoacoustic computed tomography for preclinical research and clinical translation

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Li Lin ◽  
Peng Hu ◽  
Xin Tong ◽  
Shuai Na ◽  
Rui Cao ◽  
...  
Keyword(s):  
Computed Tomography ◽  
High Speed ◽  
Three Dimensional ◽  
Biological Tissues ◽  
Clinical Translation ◽  
Breath Hold ◽  
Human Breast ◽  
Preclinical Research ◽  
Imaging Depth

AbstractPhotoacoustic computed tomography (PACT) has generated increasing interest for uses in preclinical research and clinical translation. However, the imaging depth, speed, and quality of existing PACT systems have previously limited the potential applications of this technology. To overcome these issues, we developed a three-dimensional photoacoustic computed tomography (3D-PACT) system that features large imaging depth, scalable field of view with isotropic spatial resolution, high imaging speed, and superior image quality. 3D-PACT allows for multipurpose imaging to reveal detailed angiographic information in biological tissues ranging from the rodent brain to the human breast. In the rat brain, we visualize whole brain vasculatures and hemodynamics. In the human breast, an in vivo imaging depth of 4 cm is achieved by scanning the breast within a single breath hold of 10 s. Here, we introduce the 3D-PACT system to provide a unique tool for preclinical research and an appealing prototype for clinical translation.

scholarly journals Anatomical description of the skulls of peccaries (Tayassu tajacu, Linnaeus 1758) by computed tomography

2021 ◽  
Vol 73 (4) ◽  
pp. 861-867
Author(s):  
J.R. Araújo ◽  
R.P.S. Rodrigues ◽  
F.C.A. Sousa ◽  
L.S. Moura ◽  
A.B.S. Silva ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Three Dimensional ◽  
Nasal Bone ◽  
Preclinical Research ◽  
Anatomical Structures ◽  
3D Images ◽  
Reconstruction Software ◽  
Important Diagnostic Tool ◽  
Palatal Bone ◽  
Parietal Bones

ABSTRACT The aim of this study was to evaluate the anatomical structures of the skulls of peccaries to establish the basis for their clinical study and future preclinical research. Ten skulls of adult peccaries were subjected to tomographic examination. The data obtained were processed via three-dimensional image reconstruction software (3D images). The reconstructions obtained from the neurocranium of the studied specimens allowed the identification and description of the following structures: nasal bone, frontal bone, parietal bones, incisor bone, maxillary bone, zygomatic bone, temporal bone, palatal bone, occipital bone, vomer bone, pterygoid bone, sphenoid bone, paranasal sinuses and orbit. Computed tomography proved to be an important diagnostic tool in the investigation of the skull of this species, allowing the acquisition of anatomical values not yet documented for the species in the literature.

X-ray microtomography

1988 ◽  
Vol 46 ◽  
pp. 998-999
Author(s):  
H.W. Deckman ◽  
B.F. Flannery ◽  
J.H. Dunsmuir ◽  
K.D' Amico
Keyword(s):  
Computed Tomography ◽  
Internal Structure ◽  
Imaging Technique ◽  
Three Dimensional ◽  
Tissue Structure ◽  
Individual Element ◽  
X Ray ◽  
Non Invasive ◽  
Panoramic Imaging ◽  
Three Dimensional Images

We have developed a new X-ray microscope which produces complete three dimensional images of samples. The microscope operates by performing X-ray tomography with unprecedented resolution. Tomography is a non-invasive imaging technique that creates maps of the internal structure of samples from measurement of the attenuation of penetrating radiation. As conventionally practiced in medical Computed Tomography (CT), radiologists produce maps of bone and tissue structure in several planar sections that reveal features with 1mm resolution and 1% contrast. Microtomography extends the capability of CT in several ways. First, the resolution which approaches one micron, is one thousand times higher than that of the medical CT. Second, our approach acquires and analyses the data in a panoramic imaging format that directly produces three-dimensional maps in a series of contiguous stacked planes. Typical maps available today consist of three hundred planar sections each containing 512x512 pixels. Finally, and perhaps of most import scientifically, microtomography using a synchrotron X-ray source, allows us to generate maps of individual element.

scholarly journals Accuracy and Reproducibility of Facial Measurements of Digital Photographs and Wrapped Cone Beam Computed Tomography (CBCT) Photographs

Diagnostics ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 757
Author(s):  
Maged Sultan Alhammadi ◽  
Abeer Abdulkareem Al-mashraqi ◽  
Rayid Hussain Alnami ◽  
Nawaf Mohammad Ashqar ◽  
Omar Hassan Alamir ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Soft Tissue ◽  
Cone Beam Computed Tomography ◽  
High Reliability ◽  
Three Dimensional ◽  
Cone Beam ◽  
Cross Sectional ◽  
Facial Profile ◽  
Digital Photographs ◽  
Gonial Angle

The study sought to assess whether the soft tissue facial profile measurements of direct Cone Beam Computed Tomography (CBCT) and wrapped CBCT images of non-standardized facial photographs are accurate compared to the standardized digital photographs. In this cross-sectional study, 60 patients with an age range of 18–30 years, who were indicated for CBCT, were enrolled. Two facial photographs were taken per patient: standardized and random (non-standardized). The non-standardized ones were wrapped with the CBCT images. The most used soft tissue facial profile landmarks/parameters (linear and angular) were measured on direct soft tissue three-dimensional (3D) images and on the photographs wrapped over the 3D-CBCT images, and then compared to the standardized photographs. The reliability analysis was performed using concordance correlation coefficients (CCC) and depicted graphically using Bland–Altman plots. Most of the linear and angular measurements showed high reliability (0.91 to 0.998). Nevertheless, four soft tissue measurements were unreliable; namely, posterior gonial angle (0.085 and 0.11 for wrapped and direct CBCT soft tissue, respectively), mandibular plane angle (0.006 and 0.0016 for wrapped and direct CBCT soft tissue, respectively), posterior facial height (0.63 and 0.62 for wrapped and direct CBCT soft tissue, respectively) and total soft tissue facial convexity (0.52 for both wrapped and direct CBCT soft tissue, respectively). The soft tissue facial profile measurements from either the direct 3D-CBCT images or the wrapped CBCT images of non-standardized frontal photographs were accurate, and can be used to analyze most of the soft tissue facial profile measurements.

scholarly journals Three‐dimensional X‐ray‐computed tomography of 3300‐ to 6000‐year‐old Citrullus seeds from Libya and Egypt compared to extant seeds throws doubts on species assignments

2021 ◽  
Author(s):  
Katherine A. Wolcott ◽  
Guillaume Chomicki ◽  
Yannick M. Staedler ◽  
Krystyna Wasylikowa ◽  
Mark Nesbitt ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Three Dimensional ◽  
X Ray ◽  
X Ray Computed
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