Bidirectional interface for real-time optoacoustic monitoring of transcranial ultrasound stimulation in rodents

2021 ◽  
Author(s):  
Ali Özbek ◽  
Justine Robin ◽  
Héctor Andrés Estrada Beltrán ◽  
Shy Shoham ◽  
Daniel Razanksy
Keyword(s):  
Real Time ◽  
Transcranial Ultrasound ◽  
Ultrasound Stimulation

scholarly journals Effects of Transcranial Ultrasound Stimulation on Trigeminal Blink Reflex Excitability

2021 ◽  
Vol 11 (5) ◽  
pp. 645
Author(s):  
Andrea Guerra ◽  
Edoardo Vicenzini ◽  
Ettore Cioffi ◽  
Donato Colella ◽  
Antonio Cannavacciuolo ◽  
...  
Keyword(s):  
Substantia Nigra ◽  
Superior Colliculus ◽  
Blink Reflex ◽  
Transcranial Ultrasound ◽  
Recovery Cycle ◽  
Brain Areas ◽  
Nucleus Raphe Magnus ◽  
Ultrasound Stimulation ◽  
Raphe Magnus ◽  
Interstimulus Intervals

Recent evidence indicates that transcranial ultrasound stimulation (TUS) modulates sensorimotor cortex excitability. However, no study has assessed possible TUS effects on the excitability of deeper brain areas, such as the brainstem. In this study, we investigated whether TUS delivered on the substantia nigra, superior colliculus, and nucleus raphe magnus modulates the excitability of trigeminal blink reflex, a reliable neurophysiological technique to assess brainstem functions in humans. The recovery cycle of the trigeminal blink reflex (interstimulus intervals of 250 and 500 ms) was tested before (T0), and 3 (T1) and 30 min (T2) after TUS. The effects of substantia nigra-TUS, superior colliculus-TUS, nucleus raphe magnus-TUS and sham-TUS were assessed in separate and randomized sessions. In the superior colliculus-TUS session, the conditioned R2 area increased at T1 compared with T0, while T2 and T0 values did not differ. Results were independent of the interstimulus intervals tested and were not related to trigeminal blink reflex baseline (T0) excitability. Conversely, the conditioned R2 area was comparable at T0, T1, and T2 in the nucleus raphe magnus-TUS and substantia nigra-TUS sessions. Our findings demonstrate that the excitability of brainstem circuits, as evaluated by testing the recovery cycle of the trigeminal blink reflex, can be increased by TUS. This result may reflect the modulation of inhibitory interneurons within the superior colliculus.

scholarly journals A range of pulses commonly used for human transcranial ultrasound stimulation are clearly audible

2021 ◽  
Vol 14 (5) ◽  
pp. 1353-1355
Author(s):  
Ainslie Johnstone ◽  
Tulika Nandi ◽  
Eleanor Martin ◽  
Sven Bestmann ◽  
Charlotte Stagg ◽  
...  
Keyword(s):  
Transcranial Ultrasound ◽  
Ultrasound Stimulation

scholarly journals Transcranial Ultrasound Stimulation in Anterior Cingulate Cortex Impairs Information Sampling and Learning in Loss Contexts

2021 ◽  
Author(s):  
Kianoush Banaie Boroujeni ◽  
Michelle K Sigona ◽  
Robert Louie Treuting ◽  
Manuel J Thomas ◽  
Charles F Caskey ◽  
...  
Keyword(s):  
Anterior Cingulate Cortex ◽  
Behavioral Flexibility ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Transcranial Ultrasound ◽  
Neural Signals ◽  
Visual Objects ◽  
Ultrasound Stimulation ◽  
Information Sampling

Neural activity in anterior cingulate cortex and the anterior striatum predicts which visual objects are sampled and how likely objects are paired with positive or aversive outcomes. We causally tested whether these neural signals contribute to behavioral flexibility. Disrupting with transcranial ultrasound the ACC, but not striatum, prolonged information sampling when attentional demands were high, impaired flexible learning, and reduced the ability to avoid losses. These results support a role of the ACC in guiding attention and information sampling to overcome motivational conflict during adaptive behaviors.

Non-invasive transcranial ultrasound stimulation for neuromodulation

2021 ◽  
Author(s):  
G. Darmani ◽  
T.O. Bergmann ◽  
K. Butts Pauly ◽  
C.F. Caskey ◽  
L. de Lecea ◽  
...  
Keyword(s):  
Transcranial Ultrasound ◽  
Non Invasive ◽  
Ultrasound Stimulation
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