Scattering coefficient maps acquired from optical coherence tomography aid in diagnosis of colorectal abnormalities

2021 ◽  
Author(s):  
Yifeng Zeng ◽  
William C. Chapman ◽  
Yixiao Lin ◽  
Shuying Li ◽  
Quing Zhu
Keyword(s):  
Optical Coherence Tomography ◽  
Scattering Coefficient ◽  
Optical Coherence

CHARACTERIZATION OF VITILIGO BY IN VIVO SCATTERING COEFFICIENT OF HUMAN SKIN

2011 ◽  
Vol 04 (01) ◽  
pp. 67-72 ◽  
Author(s):  
WANRONG GAO ◽  
PENG LEE ◽  
XIANLING ZHANG
Keyword(s):  
Optical Coherence Tomography ◽  
Human Skin ◽  
Experimental Results ◽  
Scattering Coefficient ◽  
Optical Coherence ◽  
Scattering Coefficients ◽  
Significant Difference

Scattering coefficients of human skin in vivo with and without vitiligo were measured with optical coherence tomography (OCT). The experimental results show that there exist significant difference between the scattering coefficient of the epidermis of in vivo human skin with and without vitiligo disease. The results may be helpful for quantitatively diagnosing or evaluating the treatment of the disease.

scholarly journals Quantitative Diagnosis of Colorectal Polyps by Spectral Domain Optical Coherence Tomography

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Chen Wang ◽  
Qinqin Zhang ◽  
Xiaojing Wu ◽  
Tao Tang ◽  
Hong Liu ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Early Diagnosis ◽  
Colorectal Polyp ◽  
Primary Diagnosis ◽  
Colorectal Polyps ◽  
Spectral Domain ◽  
Scattering Coefficient ◽  
Optical Coherence ◽  
Scattering Coefficients ◽  
Spectral Domain Oct

The principal aim of this study is to investigate the scattering coefficient of colorectal polyp tissues using an optical coherence tomography (OCT) technique. It combines the existing scattering coefficient model and spectral domain OCT to achieve method of early diagnosis of colorectal polyp in hospitals. Seventeen patients were studied, and a total of 1456 data points were extracted by curve-fitting the OCT signals into a confocal single-backscattering model. The results show that the mean scattering coefficient value for colorectal polyps is 1.91 mm−1(std: ±0.54 mm−1), which is between the values for normal and malignant tissues. In addition, we studied the difference between adenomatous polyps (n=15) and inflammatory polyps (n=2) quantitatively and found that the adenomatous tissues had lower scattering coefficients than the inflammatory ones. The quantitative measurements confirmed that OCT can be used in primary diagnosis to compensate for the deficiencies in methods of pathological diagnosis, with a great potential for early diagnosis of tissues.

scholarly journals Early detection of enamel demineralization by optical coherence tomography

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Meng-Tsan Tsai ◽  
Yen-Li Wang ◽  
Ting-Wei Yeh ◽  
Hsiang-Chieh Lee ◽  
Wen-Ju Chen ◽  
...  
Keyword(s):  
Surface Roughness ◽  
Optical Coherence Tomography ◽  
Early Stage ◽  
Scattering Coefficient ◽  
Tooth Surface ◽  
Acidic Environment ◽  
Optical Coherence ◽  
Tooth Demineralization

AbstractEnamel is the outermost layer of the tooth that protects it from invasion. In general, an acidic environment accelerates tooth demineralization, leading to the formation of cavities. Scanning electron microscopy (SEM) is conventionally used as an in vitro tool for the observation of tooth morphology changes with acid attacks. Yet, SEM has intrinsic limitations for the potential application of in vivo detection in the early demineralization process. In this study, a high-resolution optical coherence tomography (OCT) system with the axial and transverse resolutions of 2.0 and 2.7 μm in teeth has been utilized for characterizing the effect of the acidic environment (simulated by phosphoric acid) on the enamel topology. The scattering coefficient and the surface roughness of enamel can be directly derived from the OCT results, enabling a quantitative evaluation of the topology changes with demineralization. The dynamic process induced by the acid application is also recorded and analyzed with OCT, depicting the evolution of the demineralization process on enamel. Notably, the estimated enamel scattering coefficient and surface roughness significantly increase with the application time of acid and the results illustrate that the values of both parameters after demineralization are significantly larger than those obtained before the demineralization, illustrating both parameters could be effective to differentiate the healthy and demineralized teeth and determine the severity. The obtained results unambiguously illustrate that demineralization of the tooth surface can be successfully detected by OCT and further used as an indicator of early-stage cavity formation.

Research on Measurement System of Biological Tissue Parameters Based on Optical Coherence Tomography

2013 ◽  
Vol 333-335 ◽  
pp. 135-139
Author(s):  
Hai Ye ◽  
Ying Jun Gao
Keyword(s):  
Optical Coherence Tomography ◽  
Refractive Index ◽  
Measurement System ◽  
Biological Tissue ◽  
Scattering Coefficient ◽  
Optical Parameters ◽  
Optical Coherence ◽  
Tissue Samples ◽  
Non Invasive ◽  
Experimental Values

In order to measure the optical parameters of biological tissue accurately and non-invasive, the measurement system based on optical coherence tomography was analyzed and designed from two aspects of hardware and software. The refractive index was calibrated by standard refractive index solutions, experiments were preformed to obtain refractive index of tissue samples and scattering coefficient of IntralipidTMsolution with different concentrations. Results show that the experimental values of refractive index agree with the standard values roughly and scattering coefficient linear relate with concentration in IntralipidTMsolution. The measurement system designed in our experiment is accurate and reliable, simple and feasible.

scholarly journals Scattering Coefficients of Mice Organs Categorized Pathologically by Spectral Domain Optical Coherence Tomography

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Q. Q. Zhang ◽  
X. J. Wu ◽  
C. Wang ◽  
S. W. Zhu ◽  
Y. L. Wang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Curve Fitting ◽  
Spectral Domain ◽  
Scattering Coefficient ◽  
Optical Coherence ◽  
Tissue Specific ◽  
Tissue Density ◽  
Tissue Diagnosis ◽  
Scattering Coefficients

Differences in tissue density cause a variety of scattering coefficients. To quantify optical coherence tomography (OCT) images for diagnosis, the tissue's scattering coefficient is estimated by curve fitting the OCT signals to a confocal single backscattering mode. The results from a group of 30 mice show that the scattering coefficients of bone, skin, liver, brain, testis, and spleen can be categorized into three groups: a scattering coefficient between 1.947 and 2.134 mm−1: bone and skin; a scattering coefficient between 1.303 and 1.461 mm−1: liver and brain; a scattering coefficient between 0.523 and 0.634 mm−1: testis and spleen. The results indicate that the scattering coefficient is tissue specific and could be used in tissue diagnosis.

Hematocrit-dependence of the scattering coefficient of blood determined by optical coherence tomography

2006 ◽  
Author(s):  
Dirk J. Faber ◽  
Freek J. van der Meer ◽  
Maurice C. G. Aalders ◽  
Ton G. van Leeuwen
Keyword(s):  
Optical Coherence Tomography ◽  
Scattering Coefficient ◽  
Optical Coherence
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