Structural remodeling of fibrillar collagens in posterior tibial tendinopathy in three dimensional space identified using multiphoton and second harmonic generation imaging

2020 ◽  
Author(s):  
Thomas Abraham ◽  
Rebecca Koob ◽  
Nurgul Carkaci-Salli ◽  
Umur Aydogan
Keyword(s):  
Second Harmonic Generation ◽  
Harmonic Generation ◽  
Second Harmonic ◽  
Dimensional Space ◽  
Three Dimensional ◽  
Structural Remodeling ◽  
Posterior Tibial ◽  
Fibrillar Collagens ◽  
Second Harmonic Generation Imaging ◽  
Three Dimensional Space

scholarly journals Spatially-Controllable Hot Spots for Plasmon-Enhanced Second-Harmonic Generation in AgNP-ZnO Nanocavity Arrays

Nanomaterials ◽  
2018 ◽  
Vol 8 (12) ◽  
pp. 1012
Author(s):  
Shaoxin Shen ◽  
Min Gao ◽  
Rongcheng Ban ◽  
Huiyu Chen ◽  
Xiangjie Wang ◽  
...  
Keyword(s):  
Second Harmonic Generation ◽  
Hybrid Systems ◽  
Harmonic Generation ◽  
Hot Spots ◽  
Second Harmonic ◽  
Dimensional Space ◽  
Three Dimensional ◽  
Excitation Energies ◽  
High Loss ◽  
Relative Contribution

Plasmon-enhanced second-harmonic generation (PESHG) based on hybrid metal-dielectric nanostructures have extraordinary importance for developing efficient nanoscale nonlinear sources, which pave the way for new applications in photonic circuitry, quantum optics, and biosensors. However, the relatively high loss of excitation energies and the low spatial overlapping between the locally enhanced electromagnetic field and nonlinear materials still limit the promotion of nonlinear conversion performances in such hybrid systems. Here, we design and fabricate an array of silver nanoparticle-ZnO (AgNP-ZnO) nanocavities to serve as an efficient PESHG platform. The geometry of AgNP-ZnO nanocavity arrays provides a way to flexibly modulate hot spots in three-dimensional space, and to achieve a good mutual overlap of hot spots and ZnO material layers for realizing efficient SH photon generation originating from ZnO nanocavities. Compared to bare ZnO nanocavity arrays, the resulting hybrid AgNP-ZnO design of nanocavities reaches the maximum PESHG enhancement by a factor of approximately 31. Validated by simulations, we can further interpret the relative contribution of fundamental and harmonic modes to Ag-NP dependent PESHG performances, and reveal that the enhancement stems from the co-cooperation effect of plasmon-resonant enhancements both for fundamental and harmonic frequencies. Our findings offer a previously unreported method for designing efficient PESHG systems and pave a way for further understanding of a surface plasmon-coupled second-order emission mechanism for the enhancement of hybrid systems.

scholarly journals Three-Dimensional High-Resolution Second-Harmonic Generation Imaging of Endogenous Structural Proteins in Biological Tissues

2002 ◽  
Vol 82 (1) ◽  
pp. 493-508 ◽  
Author(s):  
Paul J. Campagnola ◽  
Andrew C. Millard ◽  
Mark Terasaki ◽  
Pamela E. Hoppe ◽  
Christian J. Malone ◽  
...  
Keyword(s):  
High Resolution ◽  
Second Harmonic Generation ◽  
Harmonic Generation ◽  
Second Harmonic ◽  
Three Dimensional ◽  
Biological Tissues ◽  
Structural Proteins ◽  
Second Harmonic Generation Imaging
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