Cerebral hemodynamics measured with diffuse optical spectroscopies to elucidate mechanisms of cognitive dysfunction after mild traumatic brain injury (Conference Presentation)

2020 ◽  
Author(s):  
Erin M. Buckley
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Dysfunction ◽  
Mild Traumatic Brain Injury ◽  
Cerebral Hemodynamics

Short-term DTI predictors of cognitive dysfunction in mild traumatic brain injury

Brain Injury ◽  
2008 ◽  
Vol 22 (2) ◽  
pp. 115-122 ◽  
Author(s):  
Laura Miles ◽  
Robert I. Grossman ◽  
Glyn Johnson ◽  
James S. Babb ◽  
Leonard Diller ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Dysfunction ◽  
Mild Traumatic Brain Injury ◽  
Short Term

scholarly journals Iron Metabolism Disorders for Cognitive Dysfunction After Mild Traumatic Brain Injury

2021 ◽  
Vol 15 ◽  
Author(s):  
Suna Huang ◽  
Su Li ◽  
Hua Feng ◽  
Yujie Chen
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Dysfunction ◽  
Mild Traumatic Brain Injury ◽  
Neurological Diseases ◽  
Nerve Fibers ◽  
Iron Deposition ◽  
Neural Cells ◽  
Initial Symptoms

Traumatic brain injury (TBI) is one of the most harmful forms of acute brain injury and predicted to be one of the three major neurological diseases that cause neurological disabilities by 2030. A series of secondary injury cascades often cause cognitive dysfunction of TBI patients leading to poor prognosis. However, there are still no effective intervention measures, which drive us to explore new therapeutic targets. In this process, the most part of mild traumatic brain injury (mTBI) is ignored because its initial symptoms seemed not serious. Unfortunately, the ignored mTBI accounts for 80% of the total TBI, and a large part of the patients have long-term cognitive dysfunction. Iron deposition has been observed in mTBI patients and accompanies the whole pathological process. Iron accumulation may affect long-term cognitive dysfunction from three pathways: local injury, iron deposition induces tau phosphorylation, the formation of neurofibrillary tangles; neural cells death; and neural network damage, iron deposition leads to axonal injury by utilizing the iron sensibility of oligodendrocytes. Thus, iron overload and metabolism dysfunction was thought to play a pivotal role in mTBI pathophysiology. Cerebrospinal fluid-contacting neurons (CSF-cNs) located in the ependyma have bidirectional communication function between cerebral–spinal fluid and brain parenchyma, and may participate in the pathway of iron-induced cognitive dysfunction through projected nerve fibers and transmitted factor, such as 5-hydroxytryptamine, etc. The present review provides an overview of the metabolism and function of iron in mTBI, and to seek a potential new treatment target for mTBI with a novel perspective through combined iron and CSF-cNs.

scholarly journals White matter correlates of cognitive dysfunction after mild traumatic brain injury

Neurology ◽  
2014 ◽  
Vol 83 (6) ◽  
pp. 494-501 ◽  
Author(s):  
I. D. Croall ◽  
C. J. A. Cowie ◽  
J. He ◽  
A. Peel ◽  
J. Wood ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
White Matter ◽  
Cognitive Dysfunction ◽  
Mild Traumatic Brain Injury

scholarly journals Transcranial LED therapy for cognitive dysfunction in chronic, mild traumatic brain injury: two case reports

2010 ◽  
Author(s):  
Margaret A. Naeser ◽  
Anita Saltmarche ◽  
Maxine H. Krengel ◽  
Michael R. Hamblin ◽  
Jeffrey A. Knight
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Dysfunction ◽  
Mild Traumatic Brain Injury ◽  
Case Reports ◽  
Led Therapy

The Speech-Language Pathologists' Role in Mild Traumatic Brain Injury for Middle and High School–Age Children: Viewpoints on Guidelines From the Centers for Disease Control and Prevention

2019 ◽  
Vol 28 (3) ◽  
pp. 1363-1370 ◽  
Author(s):  
Jessica Brown ◽  
Katy O'Brien ◽  
Kelly Knollman-Porter ◽  
Tracey Wallace
Keyword(s):  
High School ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Disease Control ◽  
Mild Traumatic Brain Injury ◽  
School Age Children ◽  
School Age ◽  
Speech Language Pathologists ◽  
Control And Prevention ◽  
Centers For Disease Control

Purpose The Centers for Disease Control and Prevention (CDC) recently released guidelines for rehabilitation professionals regarding the care of children with mild traumatic brain injury (mTBI). Given that mTBI impacts millions of children each year and can be particularly detrimental to children in middle and high school age groups, access to universal recommendations for management of postinjury symptoms is ideal. Method This viewpoint article examines the CDC guidelines and applies these recommendations directly to speech-language pathology practices. In particular, education, assessment, treatment, team management, and ongoing monitoring are discussed. In addition, suggested timelines regarding implementation of services by speech-language pathologists (SLPs) are provided. Specific focus is placed on adolescents (i.e., middle and high school–age children). Results SLPs are critical members of the rehabilitation team working with children with mTBI and should be involved in education, symptom monitoring, and assessment early in the recovery process. SLPs can also provide unique insight into the cognitive and linguistic challenges of these students and can serve to bridge the gap among rehabilitation and school-based professionals, the adolescent with brain injury, and their parents. Conclusion The guidelines provided by the CDC, along with evidence from the field of speech pathology, can guide SLPs to advocate for involvement in the care of adolescents with mTBI. More research is needed to enhance the evidence base for direct assessment and treatment with this population; however, SLPs can use their extensive knowledge and experience working with individuals with traumatic brain injury as a starting point for post-mTBI care.

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