Adaptive optics line-scan OCT for high-speed imaging of retinal structure and function (Conference Presentation)

2020 ◽  
Author(s):  
Vimal Prabhu Pandiyan ◽  
Aiden M. Bertelli ◽  
James Kuchenbecker ◽  
Kevin C. Boyle ◽  
Tong Ling ◽  
...  
Keyword(s):  
Adaptive Optics ◽  
High Speed ◽  
Structure And Function ◽  
High Speed Imaging ◽  
Line Scan ◽  
Retinal Structure ◽  
And Function

scholarly journals Reflective mirror-based line-scan adaptive optics OCT for imaging retinal structure and function

2021 ◽  
Vol 12 (9) ◽  
pp. 5865
Author(s):  
Vimal Prabhu Pandiyan ◽  
Xiaoyun Jiang ◽  
James A. Kuchenbecker ◽  
Ramkumar Sabesan
Keyword(s):  
Adaptive Optics ◽  
Structure And Function ◽  
Line Scan ◽  
Reflective Mirror ◽  
Retinal Structure ◽  
And Function

scholarly journals Reflective mirror-based line-scan adaptive optics OCT

2021 ◽  
Author(s):  
Vimal Prabhu Pandiyan ◽  
Xiaoyun Jiang ◽  
James A Kuchenbecker ◽  
Ramkumar Sabesan
Keyword(s):  
High Resolution ◽  
Adaptive Optics ◽  
Ex Vivo ◽  
Optical Design ◽  
Structure And Function ◽  
Line Scan ◽  
Reflective Mirror ◽  
Retinal Structure ◽  
And Function

Line-scan OCT, incorporated with adaptive optics (AO), offers high resolution, speed and sensitivity for imaging retinal structure and function in vivo. Here, we introduce its implementation with reflective mirror-based afocal telescopes, optimized for imaging light-induced retinal activity (optoretinography) and weak retinal reflections at the cellular scale. A non-planar optical design was followed based on previous recommendations with key differences specific to a line-scan geometry. The three beam paths fundamental to an OCT system -illumination/sample, detection, and reference - were modeled in Zemax optical design software to yield theoretically diffraction-limited performance over a 2.2 deg. field-of-view and 1.5 D vergence range at the eye's pupil. The performance for imaging retinal structure was exemplified by cellular-scale visualization of retinal ganglion cells, macrophages, foveal cones, and rods in human observers. The performance for functional imaging was exemplified by resolving the light-evoked optical changes in foveal cone photoreceptors where the spatial resolution was sufficient for cone spectral classification at an eccentricity 0.3 deg. from the foveal center. This enabled the first in vivo demonstration of reduced S-cone (short-wavelength cone) density in the human foveola, thus far observed only in ex vivo histological preparations. Together, the feasibility for high resolution imaging of retinal structure and function demonstrated here holds significant potential for basic science and translational applications.

Retinal Structure and Function in Perinatally HIV-Infected and cART-Treated Children: A Matched Case–Control Study

2015 ◽  
Vol 56 (6) ◽  
pp. 3945 ◽  
Author(s):  
Nazli Demirkaya ◽  
Sophie Cohen ◽  
Ferdinand W. N. M. Wit ◽  
Michael D. Abramoff ◽  
Reinier O. Schlingemann ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Structure And Function ◽  
Matched Case ◽  
Retinal Structure ◽  
And Function ◽  
Matched Case Control Study ◽  
Control Study

scholarly journals Direct observation of the setular web that fuses thoracopodal setae of a calanoid copepod into a collapsible fan

2019 ◽  
Author(s):  
George von Dassow ◽  
Richard B. Emlet
Keyword(s):  
Food Webs ◽  
Carbon Flux ◽  
High Speed ◽  
Calanoid Copepod ◽  
Swimming Performance ◽  
Structure And Function ◽  
High Speed Video ◽  
Aquatic Food ◽  
And Function ◽  
Oceanic Carbon

SummaryCopepods are numerically dominant planktonic grazers throughout the waters of Earth, preyed upon in turn by a wide diversity of pelagic animals (1,2). Their feeding and swimming performance thus has global importance to aquatic food webs and oceanic carbon flux. These crustaceans swim and feed using cuticle-covered, segmented, muscular appendages whose reach is extended greatly by setae, extracellular chitinous extensions with diverse structure and function (3). Plumose setae, with subsidiary setules arranged like barbs on a feather, have well-documented roles in generating feeding and swimming currents (4,5). Recent work showed that plumose setae of barnacle cyprid thoracopods are permanently linked by setules into a single fan that opens and closes as one sheet during high-speed swimming (6). Intersetular linkage across cyprid thoracopods may greatly decrease leakage between extended setae, ensure even spread of setae within the fan, and promote ordered collapse of the fan to avoid entanglement of adjacent appendages. Here we demonstrate similar setular webbing amongst thoracopod setae in the calanoid copepod Acartia sp. High-speed video directly documents the existence of such links, and reveals that individuals experience apparently-irreparable degradation of the setal array due to de-linkage, with likely consequences for swimming performance.

scholarly journals Retinal Structure and Function in Achromatopsia

Ophthalmology ◽  
2014 ◽  
Vol 121 (1) ◽  
pp. 234-245 ◽  
Author(s):  
Venki Sundaram ◽  
Caroline Wilde ◽  
Jonathan Aboshiha ◽  
Jill Cowing ◽  
Colin Han ◽  
...  
Keyword(s):  
Structure And Function ◽  
Retinal Structure ◽  
And Function

scholarly journals CRB2 in immature photoreceptors determines the superior-inferior symmetry of the developing retina to maintain retinal structure and function

2018 ◽  
Vol 27 (18) ◽  
pp. 3137-3153 ◽  
Author(s):  
Peter M Quinn ◽  
C Henrique Alves ◽  
Jan Klooster ◽  
Jan Wijnholds
Keyword(s):  
Structure And Function ◽  
Retinal Structure ◽  
And Function
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