Full resolution PS-OCT assessment of airway smooth muscle in a longitudinal bronchial thermoplasty study (Conference Presentation)

2020 ◽  
Author(s):  
David C. Adams ◽  
Jasmin A. Holz ◽  
Andrew F. McCrossan ◽  
Lida P. Hariri ◽  
Margit V. Szabari ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Full Resolution ◽  
Bronchial Thermoplasty

Bronchial thermoplasty induced reduction of airway smooth muscle: results from the randomized controlled TASMA trial

2019 ◽  
Author(s):  
Annika W.M. Goorsenberg ◽  
Julia N.S. D’Hooghe ◽  
Nick H.T. Ten Hacken ◽  
Els J.M. Weersink ◽  
Joris J.T.H. Roelofs ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Randomized Controlled ◽  
Bronchial Thermoplasty

Airway smooth muscle reduction after bronchial thermoplasty in severe asthma correlates with FEV 1

2019 ◽  
Vol 49 (4) ◽  
pp. 541-544 ◽  
Author(s):  
Julia N. S. d'Hooghe ◽  
Annika W. M. Goorsenberg ◽  
Nick H. T. ten Hacken ◽  
Els J. M. Weersink ◽  
Joris J. T. H. Roelofs ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Severe Asthma ◽  
Airway Smooth Muscle ◽  
Bronchial Thermoplasty

Airway smooth muscle mass reduction after Bronchial Thermoplasty in asthmatics correlates with FEV1.

2018 ◽  
Author(s):  
Julia N.S. D'Hooghe ◽  
Annika W.M. Goorsenberg ◽  
Nick H.T. Ten Hacken ◽  
Els J.M. Weersink ◽  
Joris J.T.H. Roelofs ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Muscle Mass ◽  
Airway Smooth Muscle ◽  
Mass Reduction ◽  
Bronchial Thermoplasty

Long-term modulation of airway remodeling in severe asthma following bronchial thermoplasty

2021 ◽  
pp. 2100622
Author(s):  
Nicholas Jendzjowsky ◽  
Austin Laing ◽  
Michelle Malig ◽  
John Matyas ◽  
Elaine de Heuvel ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Severe Asthma ◽  
Airway Smooth Muscle ◽  
Thermal Injury ◽  
Airway Remodeling ◽  
Post Treatment ◽  
Bronchial Epithelial ◽  
Bronchial Thermoplasty

RationaleBronchial thermoplasty is a mechanical therapeutic intervention that has been advocated as an effective treatment option for severe asthma. The mechanism is promoted as being related to the attenuation of airway smooth muscle which has been shown to occur in the short-term. However, long-term studies of the effects of bronchial thermoplasty on airway remodeling are few with only limited assessment of airway remodeling indices.ObjectivesTo evaluate the effect of bronchial thermoplasty on (a) airway epithelial and smooth muscle cells in culture, and (b), airway remodeling in patients with severe asthma who have been prescribed bronchial thermoplasty up to 12-months post-treatment.MethodsThe distribution of heat within the airway by bronchial thermoplasty was assessed in a porcine model. Culture of human airway smooth muscle cells and bronchial epithelial cells evaluated the impact of thermal injury. Histological evaluation and morphometric assessment were performed on bronchial biopsies obtained from severe asthma patients at baseline, 6-weeks, and 12-months following bronchial thermoplasty.ResultsBronchial thermoplasty resulted in heterogenous heating of the airway wall. Airway smooth muscle cell cultures sustained thermal injury, whilst bronchial epithelial cells were relatively resistant to heat. Airway smooth muscle and neural bundles were significantly reduced at 6-weeks and 12-months post-treatment. At 6-weeks post treatment, submucosal collagen was reduced, and vessel density increased, with both indices returning to baseline at 12-months. Goblet cell numbers, submucosal gland area and subbasement membrane thickness, were not significantly altered at any timepoint examined.ConclusionsBronchial thermoplasty primarily affects airway smooth muscle and nerves with the effects still present at 12-months post-treatment.

In vivo assessment of changes to canine airway smooth muscle volume following bronchial thermoplasty with OR-OCT

2021 ◽  
Author(s):  
David C. Adams ◽  
Jasmin A. Holz ◽  
Margit V. Szabari ◽  
Lida P. Hariri ◽  
Andrew F. Mccrossan ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Canine Model ◽  
Cross Sectional ◽  
Bronchial Thermoplasty ◽  
Selection Of Patients ◽  
In Vivo Assessment ◽  
Selection Of

The inability to assess and measure changes to the airway smooth muscle (ASM) in vivo is a major challenge to evaluating asthma and its clinical outcomes. Bronchial thermoplasty (BT) is a therapy for asthma that aims to reduce the severity of excessive bronchoconstriction by ablating ASM. While multiple long-term clinical studies of BT have produced encouraging results, the outcomes of BT treatment in practice have been variable, and questions remain regarding the selection of patients. Previously we have demonstrated an imaging platform called orientation-resolved optical coherence tomography that can assess ASM endoscopically using an imaging catheter compatible with bronchoscopy. In this work, we present results obtained from a longitudinal BT study performed using a canine model (n = 8) and with the goal of investigating the use of OR-OCT for measuring the effects of BT on ASM. We demonstrate that we are capable of accurately assessing ASM both before and in the weeks following the BT procedure using blinded matching to histological samples stained with Masson's Trichome (p < 0.0001, r2 = 0.79). Analysis of volumetric ASM distributions revealed significant decreases in ASM in treated airways (average cross-sectional ASM area: 0.245 ± 0.145 mm2 pre-BT and 0.166 ± 0.112 mm2 6 weeks following BT). These results demonstrate that OR-OCT can provide clinicians with the feedback necessary to better evaluate ASM and its response to BT, and may potentially play an important role in phenotyping asthma and predicting which patients are most likely to respond to BT treatment.

scholarly journals Effects of bronchial thermoplasty and cryoablation on airway smooth muscle

2021 ◽  
Vol 134 (18) ◽  
pp. 2166-2174
Author(s):  
Xuan Li ◽  
Shuan-Shuan Xie ◽  
Guo-Shu Li ◽  
Jie Zeng ◽  
Hong-Xia Duan ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Bronchial Thermoplasty

Reduction of Airway Smooth Muscle Mass after Bronchial Thermoplasty: Are We There Yet?

2015 ◽  
Vol 191 (10) ◽  
pp. 1207-1208 ◽  
Author(s):  
Peter I. Bonta ◽  
Julia d’Hooghe ◽  
Peter J. Sterk ◽  
Elisabeth H. Bel ◽  
Jouke T. Annema
Keyword(s):  
Smooth Muscle ◽  
Muscle Mass ◽  
Airway Smooth Muscle ◽  
Bronchial Thermoplasty
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