Airway smooth muscle reduction after bronchial thermoplasty in severe asthma correlates with FEV 1

2019 ◽  
Vol 49 (4) ◽  
pp. 541-544 ◽  
Author(s):  
Julia N. S. d'Hooghe ◽  
Annika W. M. Goorsenberg ◽  
Nick H. T. ten Hacken ◽  
Els J. M. Weersink ◽  
Joris J. T. H. Roelofs ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Severe Asthma ◽  
Airway Smooth Muscle ◽  
Bronchial Thermoplasty

Long-term modulation of airway remodeling in severe asthma following bronchial thermoplasty

2021 ◽  
pp. 2100622
Author(s):  
Nicholas Jendzjowsky ◽  
Austin Laing ◽  
Michelle Malig ◽  
John Matyas ◽  
Elaine de Heuvel ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Severe Asthma ◽  
Airway Smooth Muscle ◽  
Thermal Injury ◽  
Airway Remodeling ◽  
Post Treatment ◽  
Bronchial Epithelial ◽  
Bronchial Thermoplasty

RationaleBronchial thermoplasty is a mechanical therapeutic intervention that has been advocated as an effective treatment option for severe asthma. The mechanism is promoted as being related to the attenuation of airway smooth muscle which has been shown to occur in the short-term. However, long-term studies of the effects of bronchial thermoplasty on airway remodeling are few with only limited assessment of airway remodeling indices.ObjectivesTo evaluate the effect of bronchial thermoplasty on (a) airway epithelial and smooth muscle cells in culture, and (b), airway remodeling in patients with severe asthma who have been prescribed bronchial thermoplasty up to 12-months post-treatment.MethodsThe distribution of heat within the airway by bronchial thermoplasty was assessed in a porcine model. Culture of human airway smooth muscle cells and bronchial epithelial cells evaluated the impact of thermal injury. Histological evaluation and morphometric assessment were performed on bronchial biopsies obtained from severe asthma patients at baseline, 6-weeks, and 12-months following bronchial thermoplasty.ResultsBronchial thermoplasty resulted in heterogenous heating of the airway wall. Airway smooth muscle cell cultures sustained thermal injury, whilst bronchial epithelial cells were relatively resistant to heat. Airway smooth muscle and neural bundles were significantly reduced at 6-weeks and 12-months post-treatment. At 6-weeks post treatment, submucosal collagen was reduced, and vessel density increased, with both indices returning to baseline at 12-months. Goblet cell numbers, submucosal gland area and subbasement membrane thickness, were not significantly altered at any timepoint examined.ConclusionsBronchial thermoplasty primarily affects airway smooth muscle and nerves with the effects still present at 12-months post-treatment.

Long-term effects of bronchial thermoplasty on airway smooth muscle and collagen deposition in severe asthma

2016 ◽  
Author(s):  
Jamila Chakir ◽  
Ikhlass Haj Salem ◽  
Louis-Philippe Boulet ◽  
Sabrina Biardel ◽  
Noel Lampron ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Severe Asthma ◽  
Airway Smooth Muscle ◽  
Collagen Deposition ◽  
Long Term Effects ◽  
Bronchial Thermoplasty

Reduction of Airway Smooth Muscle Mass by Bronchial Thermoplasty in Patients with Severe Asthma

2014 ◽  
Vol 190 (12) ◽  
pp. 1452-1454 ◽  
Author(s):  
Marina Pretolani ◽  
Marie-Christine Dombret ◽  
Gabriel Thabut ◽  
Dominique Knap ◽  
Fatima Hamidi ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Muscle Mass ◽  
Severe Asthma ◽  
Airway Smooth Muscle ◽  
Bronchial Thermoplasty

Reply: Reduction of Airway Smooth Muscle Mass by Bronchial Thermoplasty in Patients with Severe Asthma

2015 ◽  
Vol 191 (10) ◽  
pp. 1208-1209 ◽  
Author(s):  
Michel Aubier ◽  
Marina Pretolani ◽  
Pascal Chanez ◽  
Gabriel Thabut ◽  
Marie-Pierre Debray ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Muscle Mass ◽  
Severe Asthma ◽  
Airway Smooth Muscle ◽  
Bronchial Thermoplasty

scholarly journals Mast cells are associated with exacerbations and eosinophilia in children with severe asthma

2016 ◽  
Vol 48 (5) ◽  
pp. 1320-1328 ◽  
Author(s):  
Guillaume Lezmi ◽  
Louise Galmiche-Rolland ◽  
Sabine Rioux ◽  
Francis Jaubert ◽  
Isabelle Tillie-Leblond ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Mast Cells ◽  
Severe Asthma ◽  
Airway Smooth Muscle ◽  
Eosinophilic Inflammation ◽  
Symptomatic Group ◽  
Mucosal Mast Cells ◽  
Bronchial Biopsies ◽  
Positive Correlations

The role of mast cells in the pathogenesis of childhood asthma is poorly understood. We aimed to estimate the implication of airway mucosal mast cells in severe asthma and their relationship with clinical, functional, inflammatory and remodelling parameters.Bronchial biopsies were performed in 36 children (5–18 years) with severe asthma: 24 had frequent severe exacerbations and/or daily symptoms in the previous year (symptomatic group), and 12 had few symptoms and a persistent obstructive pattern (paucisymptomatic group). Nine children without asthma were included as control subjects. We assessed mast cells in the submucosa and airway smooth muscle using c-kit antibodies and in the entire biopsy area using Giemsa.The number of submucosal mast cells was higher in the symptomatic group than in the paucisymptomatic group (p=0.02). The number of submucosal mast cells correlated with the number of severe exacerbations (p=0.02, r=0.37). There were positive correlations between the number of submucosal mast cells (p<0.01, r=0.44), airway smooth muscle mast cells (p=0.02, r= 0.40), mast cells stained by Giemsa (p<0.01, r=0.44) and submucosal eosinophils.Mast cells are associated with severe exacerbations and submucosal eosinophilic inflammation in children with severe asthma.

Full resolution PS-OCT assessment of airway smooth muscle in a longitudinal bronchial thermoplasty study (Conference Presentation)

2020 ◽  
Author(s):  
David C. Adams ◽  
Jasmin A. Holz ◽  
Andrew F. McCrossan ◽  
Lida P. Hariri ◽  
Margit V. Szabari ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Full Resolution ◽  
Bronchial Thermoplasty

scholarly journals Airway Smooth Muscle Hyperproliferation is Regulated by microRNA-221 in Severe Asthma

2013 ◽  
pp. 130814131000002 ◽  
Author(s):  
Mark M Perry ◽  
Josie E Baker ◽  
David S Gibeon ◽  
Ian M Adcock ◽  
Kian Fan Chung
Keyword(s):  
Smooth Muscle ◽  
Severe Asthma ◽  
Airway Smooth Muscle

Treatment with a sphingosine-1-phosphate analog inhibits airway remodeling following repeated allergen exposure

2012 ◽  
Vol 302 (8) ◽  
pp. L736-L745 ◽  
Author(s):  
Harry Karmouty-Quintana ◽  
Sana Siddiqui ◽  
Muhannad Hassan ◽  
Kimitake Tsuchiya ◽  
Paul-Andre Risse ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Severe Asthma ◽  
Airway Smooth Muscle ◽  
Airway Remodeling ◽  
Allergic Inflammation ◽  
Allergen Challenge ◽  
Allergen Exposure ◽  
Lipid Mediator ◽  
Synthetic Analog ◽  
Sphingosine 1 Phosphate

Sphingosine-1-phosphate (S1P) is an immunomodulatory lipid mediator that plays an important role in lymphocyte trafficking. Elevated levels of S1P are found in bronchoalveolar lavage (BAL) fluid of patients with asthma; however, its role in disease is not known. FTY720, a synthetic analog of S1P, has been shown to abrogate allergic inflammation and airway hyperresponsiveness following acute allergen challenge. However, its effects on asthmatic airway remodeling induced by repeated allergen exposure are unknown. Ovalbumin (OVA)-sensitized rats were challenged on days 14, 19, and 24 after sensitization. FTY720 or vehicle (PBS) therapy was administered 1 h prior to each challenge. BAL fluid and quantitative histological analysis were performed 48 h after the last challenge. FTY720 inhibited OVA-induced features of airway remodeling including increased airway smooth muscle mass and bronchial neovascularization, without affecting lymphocyte numbers in secondary lymphoid organs. Furthermore, CD3+ cells adjacent to airway smooth muscle bundles were increased in OVA-challenged rats but the increase was inhibited by FTY720. There was an expansion of bronchus-associated lymphoid tissue following FTY720 treatment of OVA-challenged animals. Real-time quantitative PCR revealed that Th2-associated transcription factors were inhibited following FTY720 therapy. Airway remodeling is a cardinal feature of severe asthma. These results demonstrate that allergen-driven airway remodeling can be inhibited by FTY720, offering potential new therapies for the treatment of severe asthma.

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