The study of focused ultrasound effect to increase the penetration of light for photodynamic therapy of deeper tissue

2019 ◽  
Author(s):  
Seung Hee Han ◽  
Won Seok Chang ◽  
Jae Hyuk Kim
Keyword(s):  
Photodynamic Therapy ◽  
Focused Ultrasound ◽  
Ultrasound Effect

scholarly journals High Intensity Focused Ultrasound Effect on Cardiac Tissues: Potential for Clinical Application

2000 ◽  
Vol 17 (6) ◽  
pp. 563-566 ◽  
Author(s):  
Lisa A. Lee ◽  
Claudio Simon ◽  
Edward L. Bove ◽  
Ralph S. Mosca ◽  
Emad S. Ebbini ◽  
...  
Keyword(s):  
Clinical Application ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Cardiac Tissues ◽  
Ultrasound Effect

scholarly journals MRI-based prediction of pulsed high-intensity focused ultrasound effect on tissue transport in rabbit muscle

2013 ◽  
Vol 38 (5) ◽  
pp. 1094-1102 ◽  
Author(s):  
Brian E. O'Neill ◽  
Howard Q. Vo ◽  
Hongwei Shao ◽  
Christof Karmonik ◽  
Xiaobo Zhou ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Rabbit Muscle ◽  
Ultrasound Effect

High-Intensity Focused Ultrasound Effect in Breast Cancer Nodal Metastasis

2010 ◽  
Vol 33 (2) ◽  
pp. 447-449 ◽  
Author(s):  
Gianluigi Orgera ◽  
Giuseppe Curigliano ◽  
Miltiadis Krokidis ◽  
Guido Bonomo ◽  
Lorenzo Monfardini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Nodal Metastasis ◽  
High Intensity Focused Ultrasound ◽  
Ultrasound Effect

scholarly journals Ultrasonic Activation of the Sonosensitizer Fimaporfin Enhances the Efficacy of Chemotherapy: An In Vitro Study on Rat Glioma Cells

2020 ◽  
pp. 1-7
Author(s):  
Jimmy Nguyen Le ◽  
Anders Høgset ◽  
Henry Hirschberg ◽  
Jimmy Nguyen Le ◽  
Kristian Berg ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Bacterial Infections ◽  
Focused Ultrasound ◽  
In Vitro Study ◽  
Ultrasonic Activation ◽  
Rat Glioma ◽  
Photochemical Internalization ◽  
Anti Cancer ◽  
Cancer Agent

Activation of sonosensitizers via focused ultrasound, i.e., sonodynamic therapy, has been proposed as an alternative to light-activated photodynamic therapy for the treatment of a number of conditions from cancer to bacterial infections. The use of focused ultrasound allows treatment to sites buried deep within tissues, overcoming one of the main limitations of light-based modalities. Photochemical internalization is a technique that utilizes the photochemical properties of photodynamic therapy for the release of trapped endo-lysosomal macromolecules into the cell cytoplasm, greatly enhancing their efficacy. We have examined ultrasonic activation of disulfonated tetraphenyl chlorin (fimaporfin) together with the anti-cancer agent bleomycin, termed sonochemical internalization, as an alternative to light-activated photochemical internalization. Our results indicate that, compared to drug or focused ultrasound treatment alone, focused ultrasound activation of fimaporfin together with BLM significantly inhibits the viability of glioma monolayers and the treated cells’ ability to form clonogenic colonies.

Construction of a near-infrared responsive upconversion nanoplatform against hypoxic tumors via NO-enhanced photodynamic therapy

Nanoscale ◽  
2020 ◽  
Vol 12 (14) ◽  
pp. 7875-7887 ◽  
Author(s):  
Ying Lan ◽  
Xiaohui Zhu ◽  
Ming Tang ◽  
Yihan Wu ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Upconversion Nanoparticles

A near-infrared (NIR) activated theranostic nanoplatform based on upconversion nanoparticles (UCNPs) is developed in order to overcome the hypoxia-associated resistance in photodynamic therapy by photo-release of NO upon NIR illumination.

Porphyrin-functionalized coordination star polymers and their potential applications in photodynamic therapy

2019 ◽  
Vol 10 (45) ◽  
pp. 6116-6121 ◽  
Author(s):  
Tan Ji ◽  
Lei Xia ◽  
Wei Zheng ◽  
Guang-Qiang Yin ◽  
Tao Yue ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Self Assembly ◽  
Star Polymers ◽  
New Family ◽  
Potential Applications

We present a new family of porphyrin-functionalized coordination star polymers prepared through combination of coordination-driven self-assembly and post-assembly polymerization. Their self-assembly behaviour in water and potential for photodynamic therapy were demonstrated.

A nitroreductase-activatable near-infrared theranostic photosensitizer for photodynamic therapy under mild hypoxia

2020 ◽  
Vol 56 (43) ◽  
pp. 5819-5822
Author(s):  
Jing Zheng ◽  
Yongzhuo Liu ◽  
Fengling Song ◽  
Long Jiao ◽  
Yingnan Wu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Triplet State ◽  
Near Infrared ◽  
Mild Hypoxia

In this study, a near-infrared (NIR) theranostic photosensitizer was developed based on a heptamethine aminocyanine dye with a long-lived triplet state.

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