This paper describes the design of a 21 degree-of-freedom, nine degree-of-actuation, gas-actuated arm prosthesis for transhumeral amputees. The arm incorporates a direct-drive elbow and three degree-of-freedom wrist, in addition to a 17 degree-of-freedom underactuated hand effected by five actuators. The anthropomorphic device includes full position and force sensing capability for each actuated degree of freedom and integrates a monopropellant-powered gas generator to provide on-board power for untethered operation. Design considerations addressed in this paper include the sizing of pneumatic actuators based on the requisite output energy at each joint; the development of small low-power servovalves for use with hot/cold gases; the design of compact joints with integrated position sensing; and the packaging of the actuators, on-board power, and skeletal structure within the volumetric envelope of a normal human forearm and elbow. The resulting arm prototype is intended to approach the dexterous manipulation capabilities of its anatomical counterpart while delivering approximately 50% of the force and power output of an average human arm.