Dose distribution as outcome predictor for Gamma Knife radiosurgery on vestibular schwannoma

2019 ◽  
Author(s):  
Patrick Langenhuizen ◽  
Hans van Gorp ◽  
Svetlana Zinger ◽  
Jeroen Verheul ◽  
Sieger Leenstra ◽  
...  
Keyword(s):  
Gamma Knife ◽  
Vestibular Schwannoma ◽  
Dose Distribution ◽  
Gamma Knife Radiosurgery ◽  
Outcome Predictor

MRI textures as outcome predictor for Gamma Knife radiosurgery on vestibular schwannoma

2018 ◽  
Author(s):  
Patrick Langenhuizen ◽  
Mark Legters ◽  
Svetlana Zinger ◽  
Jeroen Verheul ◽  
Peter N. de With ◽  
...  
Keyword(s):  
Gamma Knife ◽  
Vestibular Schwannoma ◽  
Gamma Knife Radiosurgery ◽  
Outcome Predictor

scholarly journals Gamma Knife Radiosurgery does not alter the copy number aberration profile in sporadic vestibular schwannoma

2020 ◽  
Vol 149 (3) ◽  
pp. 373-381
Author(s):  
Aril Løge Håvik ◽  
Ove Bruland ◽  
Dhanushan Dhayalan ◽  
Morten Lund-Johansen ◽  
Per-Morten Knappskog
Keyword(s):  
Radiation Exposure ◽  
Gamma Knife ◽  
Vestibular Schwannoma ◽  
Copy Number ◽  
Statistical Tests ◽  
Gamma Knife Radiosurgery ◽  
Copy Number Aberration ◽  
Recurrent Event ◽  
Chromosome 22 ◽  
Increased Risk

Abstract Introduction Ionizing radiation is a known etiologic factor in tumorigenesis and its role in inducing malignancy in the treatment of vestibular schwannoma has been debated. The purpose of this study was to identify a copy number aberration (CNA) profile or specific CNAs associated with radiation exposure which could either implicate an increased risk of malignancy or elucidate a mechanism of treatment resistance. Methods 55 sporadic VS, including 18 treated with Gamma Knife Radiosurgery (GKRS), were subjected to DNA whole-genome microarray and/or whole-exome sequencing. CNAs were called and statistical tests were performed to identify any association with radiation exposure. Hierarchical clustering was used to identify CNA profiles associated with radiation exposure. Results A median of 7 (0–58) CNAs were identified across the 55 VS. Chromosome 22 aberration was the only recurrent event. A median aberrant cell fraction of 0.59 (0.25–0.94) was observed, indicating several genetic clones in VS. No CNA or CNA profile was associated with GKRS. Conclusion GKRS is not associated with an increase in CNAs or alteration of the CNA profile in VS, lending support to its low risk. This also implies that there is no major issue with GKRS treatment failure being due to CNAs. In agreement with previous studies, chromosome 22 aberration is the only recurrent CNA. VS consist of several genetic clones, addressing the need for further studies on the composition of cells in this tumor.

Clinical experience of 300 vestibular schwannoma treated by gamma knife radiosurgery using a 12-Gy margin dose

2009 ◽  
Vol 71 (1) ◽  
pp. 136-137
Author(s):  
N. Massager ◽  
S. Lonneville ◽  
C. Delbrouck ◽  
L. Abeloos ◽  
D. Devriendt ◽  
...  
Keyword(s):  
Gamma Knife ◽  
Clinical Experience ◽  
Vestibular Schwannoma ◽  
Gamma Knife Radiosurgery

Temporal Lobe Gliosarcoma After Gamma Knife Radiosurgery for Vestibular Schwannoma

2016 ◽  
Vol 37 (8) ◽  
pp. 1143-1147 ◽  
Author(s):  
Joseph R. Kapurch ◽  
Jeffrey T. Jacob ◽  
Matthew L. Carlson ◽  
John L. Atkinson ◽  
Aditya Raghunathan ◽  
...  
Keyword(s):  
Gamma Knife ◽  
Temporal Lobe ◽  
Vestibular Schwannoma ◽  
Gamma Knife Radiosurgery

Gamma Knife Radiosurgery for Vestibular Schwannoma

2008 ◽  
Vol 29 (8) ◽  
pp. 1179-1186 ◽  
Author(s):  
John M. Lasak ◽  
Darren Klish ◽  
Thomas C. Kryzer ◽  
Chris Hearn ◽  
John P. Gorecki ◽  
...  
Keyword(s):  
Gamma Knife ◽  
Vestibular Schwannoma ◽  
Gamma Knife Radiosurgery

scholarly journals MS-25 * GAMMA KNIFE RADIOSURGERY FOR VESTIBULAR SCHWANNOMA: ASSESSMENT OF QUALITY AND OUTCOMES

2014 ◽  
Vol 16 (suppl 5) ◽  
pp. v132-v132
Author(s):  
M. Straza ◽  
G. Garcia ◽  
B. Hariri ◽  
R. Patel ◽  
K. Albano ◽  
...  
Keyword(s):  
Gamma Knife ◽  
Vestibular Schwannoma ◽  
Gamma Knife Radiosurgery ◽  
Quality And Outcomes
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