scholarly journals Communicating Hydrocephalus after Gamma Knife Radiosurgery for Vestibular Schwannoma: An MR Imaging Study

2008 ◽  
Vol 30 (5) ◽  
pp. 992-994 ◽  
Author(s):  
K.A. Cauley ◽  
B. Ratkovits ◽  
S.P. Braff ◽  
G. Linnell
Keyword(s):  
Mr Imaging ◽  
Gamma Knife ◽  
Vestibular Schwannoma ◽  
Gamma Knife Radiosurgery ◽  
Imaging Study ◽  
Communicating Hydrocephalus

Gamma knife radiosurgery in the management of cavernous sinus meningiomas

2000 ◽  
Vol 93 (supplement_3) ◽  
pp. 68-73 ◽  
Author(s):  
Pierre-Hugues Roche ◽  
Jean Régis ◽  
Henry Dufour ◽  
Henri-Dominique Fournier ◽  
Christine Delsanti ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Tumor Growth ◽  
Gamma Knife ◽  
Cavernous Sinus ◽  
Gamma Knife Radiosurgery ◽  
Surgical Removal ◽  
Content Type ◽  
Cavernous Sinus Meningioma ◽  
The Mean ◽  
Fine Print

Object. The authors sought to assess the functional tolerance and tumor control rate of cavernous sinus meningiomas treated by gamma knife radiosurgery (GKS). Methods. Between July 1992 and October 1998, 92 patients harboring benign cavernous sinus meningiomas underwent GKS. The present study is concerned with the first 80 consecutive patients (63 women and 17 men). Gamma knife radiosurgery was performed as an alternative to surgical removal in 50 cases and as an adjuvant to microsurgery in 30 cases. The mean patient age was 49 years (range 6–71 years). The mean tumor volume was 5.8 cm3 (range 0.9–18.6 cm3). On magnetic resonance (MR) imaging the tumor was confined in 66 cases and extensive in 14 cases. The mean prescription dose was 28 Gy (range 12–50 Gy), delivered with an average of eight isocenters (range two–18). The median peripheral isodose was 50% (range 30–70%). Patients were evaluated at 6 months, and at 1, 2, 3, 5, and 7 years after GKS. The median follow-up period was 30.5 months (range 12–79 months). Tumor stabilization after GKS was noted in 51 patients, tumor shrinkage in 25 patients, and enlargement in four patients requiring surgical removal in two cases. The 5-year actuarial progression-free survival was 92.8%. No new oculomotor deficit was observed. Among the 54 patients with oculomotor nerve deficits, 15 improved, eight recovered, and one worsened. Among the 13 patients with trigeminal neuralgia, one worsened (contemporary of tumor growing), five remained unchanged, four improved, and three recovered. In a patient with a remnant surrounding the optic nerve and preoperative low vision (3/10) the decision was to treat the lesion and deliberately sacrifice the residual visual acuity. Only one transient unexpected optic neuropathy has been observed. One case of delayed intracavernous carotid artery occlusion occurred 3 months after GKS, without permanent deficit. Another patient presented with partial complex seizures 18 months after GKS. All cases of tumor growth and neurological deficits observed after GKS occurred before the use of GammaPlan. Since the initiation of systematic use of stereotactic MR imaging and computer-assisted modern dose planning, no more side effects or cases of tumor growth have occurred. Conclusions. Gamma knife radiosurgery was found to be an effective low morbidity—related tool for the treatment of cavernous sinus meningioma. In a significant number of patients, oculomotor functional restoration was observed. The treatment appears to be an alternative to surgical removal of confined enclosed cavernous sinus meningioma and should be proposed as an adjuvant to surgery in case of extensive meningiomas.

Gamma knife surgery for vestibular schwannoma: 10-year experience of 195 cases

2005 ◽  
Vol 102 (Special_Supplement) ◽  
pp. 87-97 ◽  
Author(s):  
Wen-Yuh Chung ◽  
Kang-Du Liu ◽  
Cheng-Ying Shiau ◽  
Hsiu-Mei Wu ◽  
Ling-Wei Wang ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Gamma Knife ◽  
Vestibular Schwannoma ◽  
Tumor Volume ◽  
Radiation Effect ◽  
Gamma Knife Surgery ◽  
Homogeneous Distribution ◽  
Content Type ◽  
Fine Print

Object. The authors conducted a study to determine the optimal radiation dose for vestibular schwannoma (VS) and to examine the histopathology in cases of treatment failure for better understanding of the effects of irradiation. Methods. A retrospective study was performed of 195 patients with VS; there were 113 female and 82 male patients whose mean age was 51 years (range 11–82 years). Seventy-two patients (37%) had undergone partial or total excision of their tumor prior to gamma knife surgery (GKS). The mean tumor volume was 4.1 cm3 (range 0.04–23.1 cm3). Multiisocenter dose planning placed a prescription dose of 11 to 18.2 Gy on the 50 to 94% isodose located at the tumor margin. Clinical and magnetic resonance (MR) imaging follow-up evaluations were performed every 6 months. A loss of central enhancement was demonstrated on MR imaging in 69.5% of the patients. At the latest MR imaging assessment decreased or stable tumor volume was demonstrated in 93.6% of the patients. During a median follow-up period of 31 months resection was avoided in 96.8% of cases. Uncontrolled tumor swelling was noted in five patients at 3.5, 17, 24, 33, and 62 months after GKS, respectively. Twelve of 20 patients retained serviceable hearing. Two patients experienced a temporary facial palsy. Two patients developed a new trigeminal neuralgia. There was no treatment-related death. Histopathological examination of specimens in three cases (one at 62 months after GKS) revealed a long-lasting radiation effect on vessels inside the tumor. Conclusions. Radiosurgery had a long-term radiation effect on VSs for up to 5 years. A margin 12-Gy dose with homogeneous distribution is effective in preventing tumor progression, while posing no serious threat to normal cranial nerve function.

scholarly journals Gamma Knife Radiosurgery does not alter the copy number aberration profile in sporadic vestibular schwannoma

2020 ◽  
Vol 149 (3) ◽  
pp. 373-381
Author(s):  
Aril Løge Håvik ◽  
Ove Bruland ◽  
Dhanushan Dhayalan ◽  
Morten Lund-Johansen ◽  
Per-Morten Knappskog
Keyword(s):  
Radiation Exposure ◽  
Gamma Knife ◽  
Vestibular Schwannoma ◽  
Copy Number ◽  
Statistical Tests ◽  
Gamma Knife Radiosurgery ◽  
Copy Number Aberration ◽  
Recurrent Event ◽  
Chromosome 22 ◽  
Increased Risk

Abstract Introduction Ionizing radiation is a known etiologic factor in tumorigenesis and its role in inducing malignancy in the treatment of vestibular schwannoma has been debated. The purpose of this study was to identify a copy number aberration (CNA) profile or specific CNAs associated with radiation exposure which could either implicate an increased risk of malignancy or elucidate a mechanism of treatment resistance. Methods 55 sporadic VS, including 18 treated with Gamma Knife Radiosurgery (GKRS), were subjected to DNA whole-genome microarray and/or whole-exome sequencing. CNAs were called and statistical tests were performed to identify any association with radiation exposure. Hierarchical clustering was used to identify CNA profiles associated with radiation exposure. Results A median of 7 (0–58) CNAs were identified across the 55 VS. Chromosome 22 aberration was the only recurrent event. A median aberrant cell fraction of 0.59 (0.25–0.94) was observed, indicating several genetic clones in VS. No CNA or CNA profile was associated with GKRS. Conclusion GKRS is not associated with an increase in CNAs or alteration of the CNA profile in VS, lending support to its low risk. This also implies that there is no major issue with GKRS treatment failure being due to CNAs. In agreement with previous studies, chromosome 22 aberration is the only recurrent CNA. VS consist of several genetic clones, addressing the need for further studies on the composition of cells in this tumor.

Clinical experience of 300 vestibular schwannoma treated by gamma knife radiosurgery using a 12-Gy margin dose

2009 ◽  
Vol 71 (1) ◽  
pp. 136-137
Author(s):  
N. Massager ◽  
S. Lonneville ◽  
C. Delbrouck ◽  
L. Abeloos ◽  
D. Devriendt ◽  
...  
Keyword(s):  
Gamma Knife ◽  
Clinical Experience ◽  
Vestibular Schwannoma ◽  
Gamma Knife Radiosurgery

MRI textures as outcome predictor for Gamma Knife radiosurgery on vestibular schwannoma

2018 ◽  
Author(s):  
Patrick Langenhuizen ◽  
Mark Legters ◽  
Svetlana Zinger ◽  
Jeroen Verheul ◽  
Peter N. de With ◽  
...  
Keyword(s):  
Gamma Knife ◽  
Vestibular Schwannoma ◽  
Gamma Knife Radiosurgery ◽  
Outcome Predictor

Temporal Lobe Gliosarcoma After Gamma Knife Radiosurgery for Vestibular Schwannoma

2016 ◽  
Vol 37 (8) ◽  
pp. 1143-1147 ◽  
Author(s):  
Joseph R. Kapurch ◽  
Jeffrey T. Jacob ◽  
Matthew L. Carlson ◽  
John L. Atkinson ◽  
Aditya Raghunathan ◽  
...  
Keyword(s):  
Gamma Knife ◽  
Temporal Lobe ◽  
Vestibular Schwannoma ◽  
Gamma Knife Radiosurgery

Gamma Knife Radiosurgery for Vestibular Schwannoma

2008 ◽  
Vol 29 (8) ◽  
pp. 1179-1186 ◽  
Author(s):  
John M. Lasak ◽  
Darren Klish ◽  
Thomas C. Kryzer ◽  
Chris Hearn ◽  
John P. Gorecki ◽  
...  
Keyword(s):  
Gamma Knife ◽  
Vestibular Schwannoma ◽  
Gamma Knife Radiosurgery

scholarly journals MS-25 * GAMMA KNIFE RADIOSURGERY FOR VESTIBULAR SCHWANNOMA: ASSESSMENT OF QUALITY AND OUTCOMES

2014 ◽  
Vol 16 (suppl 5) ◽  
pp. v132-v132
Author(s):  
M. Straza ◽  
G. Garcia ◽  
B. Hariri ◽  
R. Patel ◽  
K. Albano ◽  
...  
Keyword(s):  
Gamma Knife ◽  
Vestibular Schwannoma ◽  
Gamma Knife Radiosurgery ◽  
Quality And Outcomes
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