Longitudinal matching of in vivo adaptive optics images of fluorescent cells in the human eye using stochastically consistent superpixels

2019 ◽  
Author(s):  
Jianfei Liu ◽  
Hae Won Jung ◽  
Tao Liu ◽  
Johnny Tam
Keyword(s):  
Adaptive Optics ◽  
Human Eye ◽  
Fluorescent Cells

scholarly journals In vivo sub-diffraction adaptive optics imaging of photoreceptors in the human eye with annular pupil illumination and sub-Airy detection

Optica ◽  
2021 ◽  
Author(s):  
Rongwen Lu ◽  
Nancy Aguilera ◽  
Tao Liu ◽  
Jianfei Liu ◽  
John Giannini ◽  
...  
Keyword(s):  
Adaptive Optics ◽  
Human Eye ◽  
Adaptive Optics Imaging

scholarly journals Wavefront sensorless adaptive optics OCT with the DONE algorithm for in vivo human retinal imaging [Invited]

2017 ◽  
Vol 8 (4) ◽  
pp. 2261 ◽  
Author(s):  
Hans R. G. W. Verstraete ◽  
Morgan Heisler ◽  
Myeong Jin Ju ◽  
Daniel Wahl ◽  
Laurens Bliek ◽  
...  
Keyword(s):  
Adaptive Optics ◽  
Retinal Imaging

scholarly journals In vivo Brillouin optical microscopy of the human eye

2012 ◽  
Vol 20 (8) ◽  
pp. 9197 ◽  
Author(s):  
Giuliano Scarcelli ◽  
Seok Hyun Yun
Keyword(s):  
Optical Microscopy ◽  
Human Eye

scholarly journals In vivo imaging of human retinal microvasculature using adaptive optics scanning light ophthalmoscope fluorescein angiography

2013 ◽  
Vol 4 (8) ◽  
pp. 1305 ◽  
Author(s):  
Alexander Pinhas ◽  
Michael Dubow ◽  
Nishit Shah ◽  
Toco Y. Chui ◽  
Drew Scoles ◽  
...  
Keyword(s):  
Fluorescein Angiography ◽  
Adaptive Optics ◽  
In Vivo Imaging ◽  
Retinal Microvasculature

scholarly journals High-Resolution Adaptive Optics in Vivo Autofluorescence Imaging in Stargardt Disease

2019 ◽  
Vol 137 (6) ◽  
pp. 603 ◽  
Author(s):  
Hongxin Song ◽  
Ethan A. Rossi ◽  
Qiang Yang ◽  
Charles E. Granger ◽  
Lisa R. Latchney ◽  
...  
Keyword(s):  
High Resolution ◽  
Adaptive Optics ◽  
Autofluorescence Imaging ◽  
Stargardt Disease

scholarly journals Dynamic changes in cell size and corresponding cell fate after optic nerve injury

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Benjamin M. Davis ◽  
Li Guo ◽  
Nivedita Ravindran ◽  
Ehtesham Shamsher ◽  
Veerle Baekelandt ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Cell Size ◽  
Nerve Injury ◽  
Cell Fate ◽  
Adaptive Optics ◽  
Retinal Cell ◽  
Multiple Time ◽  
Optic Nerve Injury ◽  
Over Time

AbstractIdentifying disease-specific patterns of retinal cell loss in pathological conditions has been highlighted by the emergence of techniques such as Detection of Apoptotic Retinal Cells and Adaptive Optics confocal Scanning Laser Ophthalmoscopy which have enabled single-cell visualisation in vivo. Cell size has previously been used to stratify Retinal Ganglion Cell (RGC) populations in histological samples of optic neuropathies, and early work in this field suggested that larger RGCs are more susceptible to early loss than smaller RGCs. More recently, however, it has been proposed that RGC soma and axon size may be dynamic and change in response to injury. To address this unresolved controversy, we applied recent advances in maximising information extraction from RGC populations in retinal whole mounts to evaluate the changes in RGC size distribution over time, using three well-established rodent models of optic nerve injury. In contrast to previous studies based on sampling approaches, we examined the whole Brn3a-positive RGC population at multiple time points over the natural history of these models. The morphology of over 4 million RGCs was thus assessed to glean novel insights from this dataset. RGC subpopulations were found to both increase and decrease in size over time, supporting the notion that RGC cell size is dynamic in response to injury. However, this study presents compelling evidence that smaller RGCs are lost more rapidly than larger RGCs despite the dynamism. Finally, using a bootstrap approach, the data strongly suggests that disease-associated changes in RGC spatial distribution and morphology could have potential as novel diagnostic indicators.

scholarly journals Ultra-high resolution adaptive optics: optical coherence tomography for in vivo imaging of healthy and diseased retinal structures

2008 ◽  
Author(s):  
Robert J. Zawadzki ◽  
Yan Zhang ◽  
Steven M. Jones ◽  
Stacey S. Choi ◽  
Barry Cense ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
High Resolution ◽  
Adaptive Optics ◽  
In Vivo Imaging ◽  
Optical Coherence
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