Hyperspectral, hybrid continuous wave and frequency domain diffuse optical tomography in a handheld reflectance geometry for breast cancer diagnostics

2019 ◽  
Author(s):  
Vincent Kitsmiller ◽  
Sandhya Vasudevan ◽  
Farnoush Forghani ◽  
Chris Campbell ◽  
Thomas D. O'Sullivan
Keyword(s):  
Breast Cancer ◽  
Frequency Domain ◽  
Continuous Wave ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Cancer Diagnostics ◽  
Breast Cancer Diagnostics

scholarly journals Frequency Shifting Model for Diffuse Optical Tomography

2021 ◽  
Author(s):  
Huseyin Ozgur Kazanci
Keyword(s):  
Inverse Problem ◽  
Frequency Domain ◽  
Continuous Wave ◽  
Model Problem ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Solution Space ◽  
Forward Model ◽  
Problem Solution ◽  
Frequency Shifting

Abstract Diffuse Optical Tomography (DOT) imaging technique has been interesting research field for researchers since it has uncertainties in the solution space. DOT modality is unsolved scientific problem. Inverse problem solution and image reconstruction has never been in its best quality. Reconstructed images have low spatial resolution. Scattering nature of diffusive light is the obscuring effect for DOT modality. DOT has 3 functional sub-branches which of these are Continuous Wave (CW), Time-Resolved (TR), and Frequency-Domain (FD). In this work, one new approach to Frequency Domain Diffuse Optical Tomography (FDDOT) biomedical optic imaging modality is presented to the readers. Frequency Shifting data were added to the forward model problem which basically has source-detector couplings and number of imaging voxels. 100 MHz center core light modulation frequency was selected. 169 source-detector matches were used on back-reflected imaging geometry. Absorption coefficient ma was selected 0.1 cm− 1. Scattering coefficient µs was selected 100 cm− 1. 1 micrometer x, y, z cartesian grid coordinates were used in each direction for imaging tissue-like simulation media. The total of 100 frequency shift was added to the forward model problem which has 5 Hz frequency step. 2 inclusion objects were embedded inside the imaging simulation phantom. 2 inclusion images were successfully reconstructed with the low contrast to noise ratio (CNR) error and position error (PE). Frequency shifting technique is first applied for FDDOT here. This technique has increased the total number of equations in the forward model problem; hence it is helping to solve the inverse problem. In this work, the positive effect of using multi frequency methodology was observed. Differentiation of 2 embedded inclusions was successfully completed and illustrated in this work.

Frequency-domain diffuse optical tomography with single source-detector pair for breast cancer detection

2008 ◽  
Vol 5 (4) ◽  
pp. 321-327 ◽  
Author(s):  
A G Orlova ◽  
I V Turchin ◽  
V I Plehanov ◽  
N M Shakhova ◽  
I I Fiks ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Frequency Domain ◽  
Cancer Detection ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Breast Cancer Detection ◽  
Single Source

Multicolor frequency-domain diffuse optical tomography for detection of breast cancer

2009 ◽  
Author(s):  
Anna G. Orlova ◽  
Vladislav A. Kamensky ◽  
German Yu. Golubiatnikov ◽  
Anna V. Maslennikova ◽  
Vladimir I. Plehanov ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Frequency Domain ◽  
Optical Tomography ◽  
Diffuse Optical Tomography

scholarly journals A Near-Infrared Optical Tomography System Based on Photomultiplier Tube

2007 ◽  
Vol 2007 ◽  
pp. 1-9 ◽  
Author(s):  
Huacheng Feng ◽  
Jing Bai ◽  
Xiaolei Song ◽  
Gang Hu ◽  
Junjie Yao
Keyword(s):  
Breast Cancer ◽  
Spectral Range ◽  
Near Infrared ◽  
Continuous Wave ◽  
Imaging System ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Experimental Results ◽  
Photomultiplier Tube ◽  
Tomography System

Diffuse optical tomography (DOT) is a rapidly growing discipline in recent years. It plays an important role in many fields, such as detecting breast cancer and monitoring the cerebra oxygenation. In this paper, a relatively simple, inexpensive, and conveniently used DOT system is presented in detail, in which only one photomultiplier tube is employed as the detector and an optical multiplexer is used to alter the detector channels. The 32-channel imager is consisted of 16-launch fibers and 16-detector fibers bundles, which works in the near-infrared (NIR) spectral range under continuous-wave (CW) model. The entire imaging system can work highly automatically and harmoniously. Experiments based on the proposed imaging system were performed, and the desired results can be obtained. The experimental results suggested that the proposed imaging instrumentation is effective.

Instrumentation and design of a frequency-domain diffuse optical tomography imager for breast cancer detection

1997 ◽  
Vol 1 (13) ◽  
pp. 391 ◽  
Author(s):  
Brian Pogue ◽  
Markus Testorf ◽  
Troy McBride ◽  
Ulf Osterberg ◽  
Keith Paulsen
Keyword(s):  
Breast Cancer ◽  
Frequency Domain ◽  
Cancer Detection ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Breast Cancer Detection

scholarly journals Heterodyne frequency-domain multispectral diffuse optical tomography of breast cancer in the parallel-plane transmission geometry

2016 ◽  
Vol 43 (7) ◽  
pp. 4383-4395 ◽  
Author(s):  
H. Y. Ban ◽  
M. Schweiger ◽  
V. C. Kavuri ◽  
J. M. Cochran ◽  
L. Xie ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Frequency Domain ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Parallel Plane ◽  
Transmission Geometry

Micropattern Effect on Breast Cancer Cells Behavior on Isotropically Etched Silicon Microenvironments

2010 ◽  
Author(s):  
Mehdi Nikkhah ◽  
Jeannine S. Strobl ◽  
Bhanu Peddi ◽  
Adedamola Omotosho ◽  
Masoud Agah
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Three Dimensional ◽  
Cancer Diagnostics ◽  
Breast Cancer Diagnostics ◽  
Wide Range ◽  
Etched Silicon ◽  
Directed Motility ◽  
Etched Surface ◽  
Silicon Based

In this paper we are investigating three dimensional (3-D) silicon-based microenvironments as potential platforms for breast cancer diagnostics. We have developed isotropically etched microstructures with a wide range of geometrical patterns for this purpose. Our results indicate that with the etched surface ratio of ∼65%, it is possible to capture 80–90% of the cancer cells within each silicon chip. After treatment of the cells with mitomycin C (to block the cell growth) more number of the cells are trapped inside the etched features for longer cultures times (72 h) suggesting that there is a directed motility and attraction of the cells toward the etched cavities and by optimally designing the etched features, the proposed platforms can be potentially used for diagnostics purposes.

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