InGaAs detector based Raman spectroscopy for water probing in biological tissue

2019 ◽  
Author(s):  
Shan Yang ◽  
Chirantan Sen ◽  
Jiange Zhou
Keyword(s):  
Raman Spectroscopy ◽  
Biological Tissue ◽  
Ingaas Detector

scholarly journals Sensitivity of coded aperture Raman spectroscopy to analytes beneath turbid biological tissue and tissue-simulating phantoms

2014 ◽  
Vol 19 (11) ◽  
pp. 117001 ◽  
Author(s):  
Jason R. Maher ◽  
Thomas E. Matthews ◽  
Ashley K. Reid ◽  
David F. Katz ◽  
Adam Wax
Keyword(s):  
Raman Spectroscopy ◽  
Biological Tissue ◽  
Coded Aperture ◽  
Tissue Simulating Phantoms

Implementation of a novel low-noise InGaAs detector enabling rapid near-infrared multichannel Raman spectroscopy of pigmented biological samples

2015 ◽  
Vol 46 (7) ◽  
pp. 652-660 ◽  
Author(s):  
Inês P. Santos ◽  
Peter J. Caspers ◽  
Tom Bakker Schut ◽  
Remco van Doorn ◽  
Senada Koljenović ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Biological Samples ◽  
Near Infrared ◽  
Low Noise ◽  
Ingaas Detector

PdSi focal-plane array detectors for short-wave infrared Raman spectroscopy of biological tissue: a feasibility study

1996 ◽  
Vol 35 (28) ◽  
pp. 5736 ◽  
Author(s):  
James F. Brennan ◽  
Mark E. Beattie ◽  
Yang Wang ◽  
Michael J. Cantella ◽  
Bor-Yeu Tsaur ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Feasibility Study ◽  
Biological Tissue ◽  
Focal Plane ◽  
Focal Plane Array ◽  
Short Wave ◽  
Array Detectors ◽  
Short Wave Infrared

Wide-field spontaneous Raman spectroscopy imaging system for biological tissue interrogation

2016 ◽  
Vol 41 (20) ◽  
pp. 4692 ◽  
Author(s):  
K. St-Arnaud ◽  
K. Aubertin ◽  
M. Strupler ◽  
M. Jermyn ◽  
K. Petrecca ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Biological Tissue ◽  
Imaging System ◽  
Wide Field

scholarly journals Optical penetration of surface-enhanced micro-scale spatial offset Raman spectroscopy in turbid gel and biological tissue

2021 ◽  
pp. 2141001
Author(s):  
Yumin Zhang ◽  
Li Lin ◽  
Jing He ◽  
Jian Ye
Keyword(s):  
Raman Spectroscopy ◽  
Optical Fiber ◽  
Biological Tissue ◽  
Near Infrared ◽  
Surface Enhanced Raman Spectroscopy ◽  
Agarose Gel ◽  
Porcine Muscle ◽  
Micro Scale ◽  
Surface Enhanced

The limited penetration of photons in biological tissue restricts the deep-tissue detection and imaging application. The micro-scale spatially offset Raman spectroscopy (micro-SORS) with an optical fiber probe, colleting photons from deeper regions by offsetting the position of laser excitation from the collection optics in a range of hundreds of microns, shows great potential to be integrated with endoscopy for inside-body noninvasive detection by circumventing this restriction, particularly with the combination of surface-enhanced Raman spectroscopy (SERS). However, a detailed tissue penetration study of micro-SORS in combination with SERS is still lacking. Herein, we compared the signal decay of enhanced Raman nanotags through the tissue phantom of agarose gel and the biological tissue of porcine muscle in the near-infrared (NIR) region using a portable Raman spectrometer with a micro-SORS probe (2.1[Formula: see text]mm in diameter) and a conventional hand-held probe (9.7[Formula: see text]mm in diameter). Two kinds of Raman nanotags were prepared from gold nanorods decorated with the nonresonant (4-nitrobenzenethiol) or resonant Raman reporter molecules (IR-780 iodide). The SERS measurements show that the penetration depths of two Raman nanotags are both over 2[Formula: see text]cm in agarose gel and 3[Formula: see text]mm in porcine muscle. The depth could be improved to over 4[Formula: see text]cm in agarose gel and 5[Formula: see text]mm in porcine tissue when using the micro-SORS system. This demonstrates the superiority of optical-fiber micro-SORS system over the conventional Raman detection for the detection of nanotags in deeper layers in the turbid medium and biological tissue, offering the possibility of combining the micro-SORS technique with SERS for noninvasive in vivo endoscopy-integrated clinical application.

scholarly journals Self-absorption corrected non-invasive transmission Raman spectroscopy (of biological tissue)

The Analyst ◽  
2021 ◽  
Author(s):  
Benjamin Gardner ◽  
Pavel Matousek ◽  
Nicholas Stone
Keyword(s):  
Raman Spectroscopy ◽  
Raman Spectra ◽  
Biological Tissue ◽  
Non Invasive ◽  
Transmission Raman

Higher contrast of subsurface Raman spectra is achievable with self-absorption corrected transmission Raman spectroscopy. (Desired signal in red, interfering matrix artefacts in blue.)

scholarly journals Measuring the Distribution of Taurine Molecule Inside Biological Tissue via Intrinsic Molecular Vibrations using Nonlinear Raman Spectroscopy

2015 ◽  
Vol 108 (2) ◽  
pp. 626a ◽  
Author(s):  
Masahiko Kawagishi ◽  
Yuki Obara ◽  
Takayuki Suzuki ◽  
Masumi Hayashi ◽  
Kazuhiko Misawa ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Biological Tissue ◽  
Molecular Vibrations

Emerging concepts in deep Raman spectroscopy of biological tissue

The Analyst ◽  
2009 ◽  
Vol 134 (6) ◽  
pp. 1058 ◽  
Author(s):  
Pavel Matousek ◽  
Nicholas Stone
Keyword(s):  
Raman Spectroscopy ◽  
Biological Tissue
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