Simultaneous, noninvasive, in vivo, continuous monitoring of hematocrit, vascular volume, hemoglobin oxygen saturation, pulse rate and breathing rate in humans and other animal models using a single light source

2018 ◽  
Author(s):  
James Mostrom ◽  
Richard Steinmann ◽  
J. Chaiken ◽  
Paul Dent ◽  
Sai Han Tun ◽  
...  
Keyword(s):  
Animal Models ◽  
Oxygen Saturation ◽  
Light Source ◽  
Pulse Rate ◽  
Continuous Monitoring ◽  
Breathing Rate ◽  
Saturation Pulse ◽  
Hemoglobin Oxygen Saturation ◽  
Vascular Volume

Repeatability and accuracy of fingertip pulse oximeters for measurement of hemoglobin oxygen saturation in arterial blood and pulse rate in anesthetized dogs breathing 100% oxygen

2021 ◽  
Vol 82 (4) ◽  
pp. 268-273
Author(s):  
Tamas D. Ambrisko ◽  
Stephanie C. Dantino ◽  
Stephanie C. J. Keating ◽  
Danielle E. Strahl-Heldreth ◽  
Adrianna M. Sage ◽  
...  
Keyword(s):  
Oxygen Saturation ◽  
Pulse Rate ◽  
Hemoglobin Oxygen Saturation ◽  
Arterial Blood ◽  
Anesthetized Dogs ◽  
Pulse Oximeters

Hemoglobin oxygen saturation measurements using resonance Raman intravital microscopy

2005 ◽  
Vol 289 (1) ◽  
pp. H488-H495 ◽  
Author(s):  
Ivo P. Torres Filho ◽  
James Terner ◽  
Roland N. Pittman ◽  
Leonardo G. Somera ◽  
Kevin R. Ward
Keyword(s):  
Oxygen Saturation ◽  
Raman Spectra ◽  
Raman Band ◽  
Ultraviolet Region ◽  
Excitation Wavelength ◽  
Isolated Cells ◽  
Light Power ◽  
Hemoglobin Oxygen Saturation ◽  
Rat Mesentery

A system is described for in vivo noninvasive measurements of hemoglobin oxygen saturation (HbO2Sat) at the microscopic level. The spectroscopic basis for the application is resonant Raman enhancement of Hb in the violet/ultraviolet region, allowing simultaneous identification of oxy- and deoxyhemoglobin with the same excitation wavelength. The heme vibrational bands are well known, but the technique has never been used to determine microvascular HbO2Sat in vivo. A diode laser light (power: 0.3 mW) was focused onto sample areas 15–30 μm in diameter. Raman spectra were obtained in backscattering geometry by using a microscope coupled to a spectrometer and a cooled detector. Calibration was performed in vitro by using glass capillaries containing blood at several Hb concentrations, equilibrated at various oxygen tensions. HbO2Sat was estimated using the Raman band intensities at 1,360 and 1,375 cm−1. Glass capillary path length and Hb concentration had no effect on HbO2Sat estimated from Raman spectra. In vivo observations were made in blood flowing in microvessels of the rat mesentery. The Hb Raman peaks observed in oxygenated and deoxygenated blood were consistent with earlier Raman studies that used Hb solutions and isolated cells. The method allowed HbO2Sat determinations in the whole range of arterioles, venules, and capillaries. Tissue transillumination allowed diameter and erythrocyte velocity measurements in the same vessels. Raman microspectroscopy offers distinct advantages over other currently used techniques by providing noninvasive and reliable in vivo determinations of HbO2Sat in thin tissues as well as in solid organs and tissues, which are unsuitable for techniques requiring transillumination.

Oxygen Saturation, Pulse Rate, and Particulate Air Pollution

1999 ◽  
Vol 159 (2) ◽  
pp. 365-372 ◽  
Author(s):  
C. ARDEN III POPE ◽  
DOUGLAS W. DOCKERY ◽  
RICHARD E. KANNER ◽  
G. MARTIN VILLEGAS ◽  
JOEL SCHWARTZ
Keyword(s):  
Air Pollution ◽  
Oxygen Saturation ◽  
Pulse Rate ◽  
Saturation Pulse ◽  
Particulate Air Pollution
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