Theoretical and experimental study of bent fully aperiodic large-pitch fibers for enhancing the high-order modes delocalization

2018 ◽  
Author(s):  
Remì Du Jeu ◽  
Dia Darwich ◽  
Aurélien Benoît ◽  
Baptiste M. Leconte ◽  
Marie-Alicia Malleville ◽  
...  
Keyword(s):  
Experimental Study ◽  
High Order

scholarly journals Learning the pattern of epistasis linking genotype and phenotype in a protein

2017 ◽  
Author(s):  
Frank J. Poelwijk ◽  
Michael Socolich ◽  
Rama Ranganathan
Keyword(s):  
Experimental Study ◽  
Sequence Space ◽  
Fluorescent Protein ◽  
Fluorescent Proteins ◽  
High Order ◽  
Epistatic Interactions ◽  
Stepwise Variation ◽  
Experimental Strategies ◽  
Variation And Selection ◽  
Entacmaea Quadricolor

Understanding the pattern of epistasis – the non-independence of mutations – is critical for relating genotype and phenotype in biological systems. However, the complexity of potential epistatic interactions has limited approaches to this problem at any level. To develop practical strategies, we carried out a comprehensive experimental study of epistasis between all mutations that link two phenotypically distinct variants of the Entacmaea quadricolor fluorescent protein. The data demonstrate significant high-order epistatic interactions between mutations, but also reveals extraordinary sparsity, enabling novel experimental strategies and sequence-based statistical methods for learning the relevant epistasis. The sequence space linking the parental fluorescent proteins is functionally connected through paths of single mutations; thus, high-order epistasis in proteins is consistent with evolution through stepwise variation and selection. This work initiates a path towards characterizing epistasis in proteins in general.

Experimental study on the superposition of high-order radial Laguerre-Gaussian beams

2018 ◽  
Vol 47 (12) ◽  
pp. 1207002
Author(s):  
柯熙政 Ke Xizheng ◽  
石欣雨 Shi Xinyu
Keyword(s):  
Experimental Study ◽  
High Order ◽  
Gaussian Beams
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