3-compartment talaporfin sodium pharmacokinetic model by optimization using fluorescence measurement data from canine skin to estimate the concentration in interstitial space

2018 ◽  
Author(s):  
Yuko Uno ◽  
Emiyu Ogawa ◽  
Eitaro Aiyoshi ◽  
Tsunenori Arai
Keyword(s):  
Pharmacokinetic Model ◽  
Measurement Data ◽  
Interstitial Space ◽  
Fluorescence Measurement ◽  
Talaporfin Sodium

scholarly journals A Three-Compartment Pharmacokinetic Model to Predict the Interstitial Concentration of Talaporfin Sodium in the Myocardium for Photodynamic Therapy: A Method Combining Measured Fluorescence and Analysis of the Compartmental Origin of the Fluorescence

2018 ◽  
Vol 6 (1) ◽  
pp. 1
Author(s):  
Yuko Uno ◽  
Emiyu Ogawa ◽  
Eitaro Aiyoshi ◽  
Tsunenori Arai
Keyword(s):  
Photodynamic Therapy ◽  
Plasma Concentration ◽  
Rate Constants ◽  
Pharmacokinetic Model ◽  
Interstitial Space ◽  
Differential Rate ◽  
Talaporfin Sodium ◽  
Interstitial Concentration ◽  
Sodium Plasma ◽  
Canine Myocardium

To evaluate the effectiveness of photodynamic therapy occurring in the interstitial space of the myocardium, we estimated the interstitial concentration of talaporfin sodium in the canine myocardium by constructing a three-compartment pharmacokinetic model based on measured changes in talaporfin sodium plasma concentration and myocardial fluorescence. Differential rate equations of talaporfin sodium concentration in the plasma, interstitial space, and cell compartment were developed with individual compartment volume, concentration, and rate constants. Using measured volume ratios based on histological examinations, we defined that the myocardial fluorescence consisted of the linear addition of fluorescence generated from these three compartments. The rate constants were obtained by fitting to minimize the sum of the squared errors between the measured talaporfin sodium concentrations and the calculated concentrations divided by the number of data points using the conjugate gradient method in MATLAB. We confirmed that this fitting operation may be appropriate, because a coefficient of determination between the measured talaporfin sodium changes and the calculated concentrations using our equations was 0.99. Consequently, to estimate the interstitial concentration in the canine myocardium, we propose a three-compartment pharmacokinetic model construction methodology using measured changes in talaporfin sodium plasma concentration and changes in myocardial fluorescence.

scholarly journals Towards instantaneous quantitative fluoroimaging drugs determination in body fluids with no added reagents

2010 ◽  
Vol 24 (3-4) ◽  
pp. 317-324 ◽  
Author(s):  
Natalia V. Strashnikova ◽  
Arcady P. Gershanik ◽  
Nona Papiashvili ◽  
Daniel Khankin ◽  
Rivka Cohen-Luria ◽  
...  
Keyword(s):  
Chemical Nature ◽  
Full Range ◽  
Measurement Data ◽  
Data Bank ◽  
Body Fluids ◽  
Fluorescence Measurement ◽  
Fluorescence Measurements ◽  
Recognition Software ◽  
User Friendly ◽  
Network Pattern

Our objective is to develop a simple monitoring technique for rapid, sensitive and quantitative drugs detection in body fluids, with no reagent added and no need for qualified professionals. The user-friendly automatic Fluo-imager will (a) measure the full-range 3D fluorescence map of the inserted fluid sample, (b) determine the chemical nature and concentration of the drugs and (c) transfer the results through internet to the diagnosis center. For these goals the fluorescence measurement data will be examined by neuronal network-pattern recognition software. The software identifies the chemical nature and the appropriate concentration of the drug by comparison of the obtained 3D pattern with the contents of the data bank. One of the problems in the approach under consideration is the high optical density of body fluids in the UV region, which raises difficulties in the fluorescence measurements. In this paper, we have attempted to overcome this problem by means of preliminary dilution. Nevertheless, the problem of subtraction of the fluid fluorescence background still needs to be addressed.

scholarly journals Handheld real-time PCR device

Lab on a Chip ◽  
2016 ◽  
Vol 16 (3) ◽  
pp. 586-592 ◽  
Author(s):  
Christian D. Ahrberg ◽  
Bojan Robert Ilic ◽  
Andreas Manz ◽  
Pavel Neužil
Keyword(s):  
Real Time ◽  
Real Time Pcr ◽  
Point Of Care ◽  
Measurement Data ◽  
Integrated System ◽  
Fluorescence Measurement ◽  
Detection Capability ◽  
Fully Integrated ◽  
Lcd Display

World's smallest, fully autonomous, handheld real-time PCR was shown in this contribution. The device can quickly process up to four samples at a time with detection capability of a single DNA copy. The fully integrated system includes all required electronics for fluorescence measurement, data viewing (LCD display) and processing, and is ideal for use in small clinics and point-of-care applications.

Metrological support of individual blood glucose meters in telemedicine

2019 ◽  
pp. 52-56
Author(s):  
Yu.F. Glukhov ◽  
N.V. Krutikov ◽  
A.V. Ivanov ◽  
N.P. Muravskaya
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Measurement Data ◽  
Test Method ◽  
Level Measurement ◽  
Measurement Devices ◽  
Real Practice ◽  
Health Care Centers ◽  
Medical Measurement

We have studied and analyzed status and metrological supervision of blood glucose monitors, individual devices for a person’s blood glucose level measurement. It has been indicated that nowadays blood glucose monitors like other individual devices for medical measurement are not allowed to be involved in telemedicine public service. This accounts for absence of metrological supervision with these measurement devices in telemedicine. In addition, the key problem is absence of safe methods and means of remote verificaition, calibration and transmission of measurement data to health care centers. The article offers a remote test method for blood glucose monitors using a number of resistors with values correlating with measured blood glucose level. The available method has been successfully trialed in real practice.

Intelligent building development and LabView-based modelling of a net zero-energy strategy

2014 ◽  
Vol 5 (2) ◽  
pp. 157-166 ◽  
Author(s):  
Cs. Szász
Keyword(s):  
Development Strategy ◽  
Measurement Data ◽  
Renewable Energy Resources ◽  
Balance Performance ◽  
Zero Energy ◽  
Intelligent Building ◽  
Labview Software ◽  
Net Zero Energy ◽  
Net Zero Energy Building ◽  
Net Zero

The paper presents an intelligent building (IB) development strategy emphasizing the locally available non-polluting renewable energy resources utilization. Considering the immense complexity of the topic, the implementation strategy of the main energy-flow processes is unfolded, using the net zero-energy building concept (NZEB). Noticeably, in the first research steps the mathematical background of the considered NZEB strategy has been developed and presented. Then careful LabView software-based simulations prove that the adopted strategy is feasible for implementation. The result of the above mentioned research efforts is a set of powerful and versatile software toolkits well suitable to model and simulate complex heating, ventilation and air-conditioning processes and to perform energy balance performance evaluations. Besides the elaborated mathematical models, concrete software implementation examples and measurement data also is provided in the paper. Finally, the proposed original models offer a feasible solution for future developments and research in NZEB applications modelling and simulation purposes.

Pharmacokinetic model of circulating covalent aggregates of insulin

Diabetes ◽  
1988 ◽  
Vol 37 (8) ◽  
pp. 1059-1063 ◽  
Author(s):  
M. Maislos ◽  
M. Bialer ◽  
P. M. Mead ◽  
D. C. Robbins
Keyword(s):  
Pharmacokinetic Model

Soil/Tire Interaction Analysis Using FEM and FVM

2005 ◽  
Vol 33 (1) ◽  
pp. 38-62 ◽  
Author(s):  
S. Oida ◽  
E. Seta ◽  
H. Heguri ◽  
K. Kato
Keyword(s):  
Large Scale ◽  
Interaction Analysis ◽  
Yield Criterion ◽  
Surrounding Medium ◽  
Flow Analysis ◽  
Measurement Data ◽  
Traction Force ◽  
Elastoplastic Material ◽  
The Road ◽  
Soil Flow

Abstract Vehicles, such as an agricultural tractor, construction vehicle, mobile machinery, and 4-wheel drive vehicle, are often operated on unpaved ground. In many cases, the ground is deformable; therefore, the deformation should be taken into consideration in order to assess the off-the-road performance of a tire. Recent progress in computational mechanics enabled us to simulate the large scale coupling problem, in which the deformation of tire structure and of surrounding medium can be interactively considered. Using this technology, hydroplaning phenomena and tire traction on snow have been predicted. In this paper, the simulation methodology of tire/soil coupling problems is developed for pneumatic tires of arbitrary tread patterns. The Finite Element Method (FEM) and the Finite Volume Method (FVM) are used for structural and for soil-flow analysis, respectively. The soil is modeled as an elastoplastic material with a specified yield criterion and a nonlinear elasticity. The material constants are referred to measurement data, so that the cone penetration resistance and the shear resistance are represented. Finally, the traction force of the tire in a cultivated field is predicted, and a good correlation with experiments is obtained.

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