Potentiation of antimicrobial photodynamic inactivation by potassium iodide and other inorganic salts (Conference Presentation)

2018 ◽  
Author(s):  
Michael R. Hamblin
Keyword(s):  
Potassium Iodide ◽  
Inorganic Salts ◽  
Photodynamic Inactivation

scholarly journals Photodynamic inactivation of microorganisms sensitized by cationic BODIPY derivatives potentiated by potassium iodide

2017 ◽  
Vol 16 (10) ◽  
pp. 1524-1536 ◽  
Author(s):  
Eugenia Reynoso ◽  
Ezequiel D. Quiroga ◽  
Maximiliano L. Agazzi ◽  
María B. Ballatore ◽  
Sonia G. Bertolotti ◽  
...  
Keyword(s):  
Potassium Iodide ◽  
Photodynamic Inactivation ◽  
Microbial Cells

Photoinactivation of microbial cells mediated by BODIPYs 3 and 4 was potentiated by the addition of potassium iodide.

scholarly journals Potassium Iodide Potentiates Broad-Spectrum Antimicrobial Photodynamic Inactivation Using Photofrin

2017 ◽  
Vol 3 (4) ◽  
pp. 320-328 ◽  
Author(s):  
Liyi Huang ◽  
Grzegorz Szewczyk ◽  
Tadeusz Sarna ◽  
Michael R. Hamblin
Keyword(s):  
Potassium Iodide ◽  
Broad Spectrum ◽  
Photodynamic Inactivation

scholarly journals Tetracyclines: light-activated antibiotics?

2019 ◽  
Vol 11 (18) ◽  
pp. 2427-2445 ◽  
Author(s):  
Michael R Hamblin ◽  
Heidi Abrahamse
Keyword(s):  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Potassium Iodide ◽  
Side Effect ◽  
Bactericidal Effect ◽  
Photodynamic Inactivation ◽  
Oxygen Species ◽  
Bacterial Cells ◽  
Light Activation ◽  
Bacterial Regrowth

Tetracyclines are well established antibiotics but show phototoxicity as a side effect. Antimicrobial photodynamic inactivation uses nontoxic dyes combined with harmless light to destroy microbial cells by reactive oxygen species. Tetracyclines (demeclocycline and doxycycline) can act as light-activated antibiotics by binding to bacterial cells and killing them only upon illumination. The remaining tetracyclines can prevent bacterial regrowth after illumination has ceased. Antimicrobial photodynamic inactivation can be potentiated by potassium iodide. Azide quenched the formation of iodine, but not hydrogen peroxide. Demeclotetracycline (but not doxycycline) iodinated tyrosine after light activation in the presence of potassium iodide. Bacteria are killed by photoactivation of tetracyclines in the absence of oxygen. Since topical tetracyclines are already used clinically, blue light activation may increase the bactericidal effect.

scholarly journals Bacterial Photodynamic Inactivation Mediated by Methylene Blue and Red Light Is Enhanced by Synergistic Effect of Potassium Iodide

2015 ◽  
Vol 59 (9) ◽  
pp. 5203-5212 ◽  
Author(s):  
Daniela Vecchio ◽  
Asheesh Gupta ◽  
Liyi Huang ◽  
Giacomo Landi ◽  
Pinar Avci ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Potassium Iodide ◽  
Bacterial Species ◽  
Red Light ◽  
Multidrug Resistant ◽  
Photodynamic Inactivation ◽  
Bacterial Killing ◽  
Risk Of Death

ABSTRACTThe inexorable increase of antibiotic resistance occurring in different bacterial species is increasing the interest in developing new antimicrobial treatments that will be equally effective against multidrug-resistant strains and will not themselves induce resistance. One of these alternatives may be photodynamic inactivation (PDI), which uses a combination of nontoxic dyes, called photosensitizers (PS), excited by harmless visible light to generate reactive oxygen species (ROS) by type 1 (radical) and type 2 (singlet oxygen) pathways. In this study, we asked whether it was possible to improve the efficacy of PDIin vitroandin vivoby addition of the inert salt potassium iodide (KI) to a commonly investigated PS, the phenothiazinium dye methylene blue (MB). By adding KI, we observed a consistent increase of red light-mediated bacterial killing of Gram-positive and Gram-negative speciesin vitroandin vivo. In vivo, we also observed less bacterial recurrence in wounds in the days posttreatment. The mechanism of action is probably due to formation of reactive iodine species that are produced quickly with a short lifetime. This finding may have a relevant clinical impact by reducing the risk of amputation and, in some cases, the risk of death, leading to improvement in the care of patients affected by localized infections.

XX.—Certain Quinoline and Benzacridine Derivatives yielding Coloured Adsorption Compounds with Iodine

1931 ◽  
Vol 50 ◽  
pp. 243-261 ◽  
Author(s):  
William Ogilvy Kermack ◽  
Robert Henry Slater ◽  
Walter Thomas Spragg
Keyword(s):  
Nitrogen Atom ◽  
Potassium Iodide ◽  
Inorganic Salts ◽  
Hydrogen Ions ◽  
Colloidal Solutions ◽  
Low Concentrations ◽  
Derivatives Of ◽  
Positively Charged

SummaryCertain derivatives of benzacridine and of 4-anilinoquinoline give a blue or red colouration with a solution of iodine in aqueous potassium iodide. In the case of the active anilinoquinoline compounds the colour is usually developed in presence of solutions containing iodine at a concentration of the order of N/10,000, whilst in the case of the benzacridine compounds the colour is still apparent at concentrations of N/100,000 or even less. The effect of variation of concentration of compound, iodine, and hydrogen ions has been investigated in certain instances. The action of certain inorganic salts has also been investigated, but in low concentrations these are without much effect. The methosulphates of the two active benzacridine bases also develop colours with iodine even with very low concentrations of the latter. It is suggested that these methosulphates form micellar, colloidal solutions. The chromogenic property appears to depend not on the nitrogen atom in these compounds but on the structure of the molecule as a whole. The compounds which have been investigated differ from most of those previously known to give colours with iodine, in that they are basic and form colloidal solutions in which the particles are positively charged.

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