scholarly journals Photodynamic inactivation of microorganisms sensitized by cationic BODIPY derivatives potentiated by potassium iodide

2017 ◽  
Vol 16 (10) ◽  
pp. 1524-1536 ◽  
Author(s):  
Eugenia Reynoso ◽  
Ezequiel D. Quiroga ◽  
Maximiliano L. Agazzi ◽  
María B. Ballatore ◽  
Sonia G. Bertolotti ◽  
...  
Keyword(s):  
Potassium Iodide ◽  
Photodynamic Inactivation ◽  
Microbial Cells

Photoinactivation of microbial cells mediated by BODIPYs 3 and 4 was potentiated by the addition of potassium iodide.

scholarly journals Potassium Iodide Potentiates Broad-Spectrum Antimicrobial Photodynamic Inactivation Using Photofrin

2017 ◽  
Vol 3 (4) ◽  
pp. 320-328 ◽  
Author(s):  
Liyi Huang ◽  
Grzegorz Szewczyk ◽  
Tadeusz Sarna ◽  
Michael R. Hamblin
Keyword(s):  
Potassium Iodide ◽  
Broad Spectrum ◽  
Photodynamic Inactivation

scholarly journals Tetracyclines: light-activated antibiotics?

2019 ◽  
Vol 11 (18) ◽  
pp. 2427-2445 ◽  
Author(s):  
Michael R Hamblin ◽  
Heidi Abrahamse
Keyword(s):  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Potassium Iodide ◽  
Side Effect ◽  
Bactericidal Effect ◽  
Photodynamic Inactivation ◽  
Oxygen Species ◽  
Bacterial Cells ◽  
Light Activation ◽  
Bacterial Regrowth

Tetracyclines are well established antibiotics but show phototoxicity as a side effect. Antimicrobial photodynamic inactivation uses nontoxic dyes combined with harmless light to destroy microbial cells by reactive oxygen species. Tetracyclines (demeclocycline and doxycycline) can act as light-activated antibiotics by binding to bacterial cells and killing them only upon illumination. The remaining tetracyclines can prevent bacterial regrowth after illumination has ceased. Antimicrobial photodynamic inactivation can be potentiated by potassium iodide. Azide quenched the formation of iodine, but not hydrogen peroxide. Demeclotetracycline (but not doxycycline) iodinated tyrosine after light activation in the presence of potassium iodide. Bacteria are killed by photoactivation of tetracyclines in the absence of oxygen. Since topical tetracyclines are already used clinically, blue light activation may increase the bactericidal effect.

scholarly journals Bacterial Photodynamic Inactivation Mediated by Methylene Blue and Red Light Is Enhanced by Synergistic Effect of Potassium Iodide

2015 ◽  
Vol 59 (9) ◽  
pp. 5203-5212 ◽  
Author(s):  
Daniela Vecchio ◽  
Asheesh Gupta ◽  
Liyi Huang ◽  
Giacomo Landi ◽  
Pinar Avci ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Potassium Iodide ◽  
Bacterial Species ◽  
Red Light ◽  
Multidrug Resistant ◽  
Photodynamic Inactivation ◽  
Bacterial Killing ◽  
Risk Of Death

ABSTRACTThe inexorable increase of antibiotic resistance occurring in different bacterial species is increasing the interest in developing new antimicrobial treatments that will be equally effective against multidrug-resistant strains and will not themselves induce resistance. One of these alternatives may be photodynamic inactivation (PDI), which uses a combination of nontoxic dyes, called photosensitizers (PS), excited by harmless visible light to generate reactive oxygen species (ROS) by type 1 (radical) and type 2 (singlet oxygen) pathways. In this study, we asked whether it was possible to improve the efficacy of PDIin vitroandin vivoby addition of the inert salt potassium iodide (KI) to a commonly investigated PS, the phenothiazinium dye methylene blue (MB). By adding KI, we observed a consistent increase of red light-mediated bacterial killing of Gram-positive and Gram-negative speciesin vitroandin vivo. In vivo, we also observed less bacterial recurrence in wounds in the days posttreatment. The mechanism of action is probably due to formation of reactive iodine species that are produced quickly with a short lifetime. This finding may have a relevant clinical impact by reducing the risk of amputation and, in some cases, the risk of death, leading to improvement in the care of patients affected by localized infections.

scholarly journals Efficient photodynamic inactivation of Candida albicans by porphyrin and potassium iodide co-encapsulation in micelles

2020 ◽  
Vol 19 (8) ◽  
pp. 1063-1071
Author(s):  
Kelly A. D. F. Castro ◽  
Guilherme T. P. Brancini ◽  
Letícia D. Costa ◽  
Juliana C. Biazzotto ◽  
M. Amparo F. Faustino ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Visible Light ◽  
Potassium Iodide ◽  
Photodynamic Inactivation

Co-encapsulation of a neutral porphyrin photosensitizer (designated as P1) and KI into micelles in combination with visible light to produce ROS and iodine is a promising approach for increasing the efficiency of PDT treatment.

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